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8ENX	Crystal structure of beta'-COPI-WD40 domain Y33A mutant in complex with SARS-CoV-2 clientized spike tail heptapeptide. Descriptor: Clientized spike tail heptapeptide, Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENY	Crystal structure of alpha-COPI-WD40 domain R13A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENZ	Crystal structure of alpha-COPI-WD40 domain K15A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8EO0	Crystal structure of alpha-COPI WD40 domain R300A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-01 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENS	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide Descriptor: Coatomer subunit beta', spike tail hepta-peptide Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENW	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 clientized spike tail heptapeptide. Descriptor: 1,2-ETHANEDIOL, Clientized spike tail peptide, Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8F93	WDR5 covalently modified at Y228 by (R)-2-SF Descriptor: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... Authors: Taunton, J, Craven, G.B, Chen, Y. Deposit date: 2022-11-23 Release date: 2023-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
8G3C	Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor) Descriptor: N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8G3E	Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) Descriptor: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.33 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
7WVK	Crystal structure of human WDR5 in complex with compound 19 Descriptor: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... Authors: Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. Deposit date: 2022-02-10 Release date: 2022-10-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
8KB9	Structure of the WDR91 WD40 domain Descriptor: WD repeat-containing protein 91 Authors: Li, J, Ma, X.L, Banerjee, S, Dong, Z.G. Deposit date: 2023-08-04 Release date: 2024-08-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the WDR91 WD40 domain To Be Published
3MMY	Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclear pore complex protein Nup98, mRNA export factor Authors: Hoelz, A, Ren, Y. Deposit date: 2010-04-20 Release date: 2010-06-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc.Natl.Acad.Sci.USA, 107, 2010
2TRC	PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX Descriptor: GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN Authors: Gaudet, R, Bohm, A, Sigler, P.B. Deposit date: 1997-01-06 Release date: 1997-06-05 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell(Cambridge,Mass.), 87, 1996
4KFM	Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits Descriptor: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Whorton, M.R, MacKinnon, R. Deposit date: 2013-04-27 Release date: 2013-06-12 Last modified: 2013-09-11 Method: X-RAY DIFFRACTION (3.45 Å) Cite: X-ray structure of the mammalian GIRK2-beta gamma G-protein complex. Nature, 498, 2013
4WJV	Crystal structure of Rsa4 in complex with the Nsa2 binding peptide Descriptor: Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... Authors: Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. Deposit date: 2014-10-01 Release date: 2014-11-19 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
4WJU	Crystal structure of Rsa4 from Saccharomyces cerevisiae Descriptor: GLYCEROL, Ribosome assembly protein 4 Authors: Holdermann, I, Bassler, J, Hurt, E, Sinning, I. Deposit date: 2014-10-01 Release date: 2014-11-19 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
5HYN	Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide Descriptor: H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... Authors: Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. Deposit date: 2016-02-01 Release date: 2016-05-11 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7, 2016
4X63	Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH Descriptor: Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, Protein arginine N-methyltransferase 5, ... Authors: Boriack-Sjodin, P.A. Deposit date: 2014-12-06 Release date: 2015-04-22 Last modified: 2015-05-27 Method: X-RAY DIFFRACTION (3.05 Å) Cite: A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
4BL0	Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105 Descriptor: CELL CYCLE ARREST PROTEIN BUB3, CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, MAGNESIUM ION, ... Authors: Primorac, I, Weir, J.R, Musacchio, A. Deposit date: 2013-04-30 Release date: 2013-09-18 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Bub3 Reads Phosphorylated Melt Repeats to Promote Spindle Assembly Checkpoint Signaling Elife, 2, 2013
4BZK	The structure of the COPII coat assembled on membranes Descriptor: Protein transport protein SEC13, Protein transport protein SEC31 Authors: Zanetti, G, Prinz, S, Daum, S, Meister, A, Schekman, R, Bacia, K, Briggs, J.A.G. Deposit date: 2013-07-26 Release date: 2013-09-18 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (40 Å) Cite: The Structure of the Copii Transport-Vesicle Coat Assembled on Membranes Elife, 2, 2013
1GOT	HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS Descriptor: GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... Authors: Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B. Deposit date: 1996-08-07 Release date: 1997-03-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2 Å) Cite: The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379, 1996
1GP2	G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND Descriptor: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... Authors: Wall, M.A, Sprang, S.R. Deposit date: 1996-11-13 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
1GG2	G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND Descriptor: G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, ... Authors: Wall, M.A, Sprang, S.R. Deposit date: 1996-11-13 Release date: 1997-02-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell(Cambridge,Mass.), 83, 1995
2AQ5	Crystal Structure of Murine Coronin-1 Descriptor: Coronin-1A Authors: Appleton, B.A, Wu, P, Wiesmann, C. Deposit date: 2005-08-17 Release date: 2005-12-06 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure, 14, 2006
2XYI	Crystal Structure of Nurf55 in complex with a H4 peptide Descriptor: DI(HYDROXYETHYL)ETHER, HISTONE H4, PROBABLE HISTONE-BINDING PROTEIN CAF1, ... Authors: Stirnimann, C.U, Nowak, A.J, Mueller, C.W. Deposit date: 2010-11-17 Release date: 2011-05-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Chromatin-Modifying Complex Component Nurf55/P55 Associates with Histones H3, H4 and Polycomb Repressive Complex 2 Subunit Su(Z)12 Through Partially Overlapping Binding Sites. J.Biol.Chem., 286, 2011

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