5TD8
 
 | | Crystal structure of an Extended Dwarf Ndc80 Complex | | Descriptor: | Kinetochore protein NDC80, Kinetochore protein NUF2, Kinetochore protein SPC24, ... | | Authors: | Valverde, R, Ingram, J, Harrison, S.C. | | Deposit date: | 2016-09-17 | | Release date: | 2016-11-16 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (7.531 Å) | | Cite: | Conserved Tetramer Junction in the Kinetochore Ndc80 Complex.
Cell Rep, 17, 2016
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5TEF
 | | Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, Gem-associated protein 5, ... | | Authors: | Chao, X, Tempel, W, Bian, C, He, H, Cerovina, T, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-21 | | Release date: | 2016-10-19 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
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5TFR
 | | Crystal structure of Zika Virus NS5 protein | | Descriptor: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Longenecker, K.L, Upadhyay, A.K. | | Deposit date: | 2016-09-26 | | Release date: | 2016-10-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5TIL
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5TJ2
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5TJR
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5SUU
 | | X-ray crystallographic structure of a covalent trimer derived from A-beta 17-36. X-ray diffractometer data set. (ORN)CVFFCED(ORN)AII(SAR)L(ORN)V. | | Descriptor: | 16mer A-beta peptide: ORN-CYS-VAL-PHE-PHE-CYS-GLU-ASP-ORN-ALA-ILE-ILE-SAR-LEU-ORN-VAL, CHLORIDE ION, IODIDE ION | | Authors: | Kreutzer, A.G, Spencer, R.K, Nowick, J.S. | | Deposit date: | 2016-08-03 | | Release date: | 2017-01-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.032 Å) | | Cite: | Stabilization, Assembly, and Toxicity of Trimers Derived from A beta.
J.Am.Chem.Soc., 139, 2017
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5SUR
 | | X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36. Synchrotron data set. (ORN)CVF(MEA)CED(ORN)AIIGL(ORN)V. | | Descriptor: | 16mer A-beta peptide: ORN-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORN-ALA-ILE-ILE-GLY-LEU-ORN-VAL, CHLORIDE ION, HEXANE-1,6-DIOL, ... | | Authors: | Kreutzer, A.G, Yoo, S, Nowick, J.S. | | Deposit date: | 2016-08-03 | | Release date: | 2017-01-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Stabilization, Assembly, and Toxicity of Trimers Derived from A beta.
J.Am.Chem.Soc., 139, 2017
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5SUP
 | | Crystal structure of the Sub2-Yra1 complex in association with RNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase SUB2, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Ren, Y, Schmiege, P, Blobel, G. | | Deposit date: | 2016-08-03 | | Release date: | 2017-01-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1.
Elife, 6, 2017
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5T6E
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5T6M
 | | Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound | | Descriptor: | (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ... | | Authors: | Buller, A.R, van Roye, P, Arnold, F.H. | | Deposit date: | 2016-09-01 | | Release date: | 2016-12-21 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.
Biochemistry, 55, 2016
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5TBX
 | | hnRNP A18 RNA Recognition Motif | | Descriptor: | ACETATE ION, Cold-inducible RNA-binding protein, NICKEL (II) ION | | Authors: | Coburn, K.M, Melville, Z, Aligholizadeh, E, Roth, B.M, Varney, K.M, Weber, D.J. | | Deposit date: | 2016-09-13 | | Release date: | 2017-04-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.767 Å) | | Cite: | Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5TDN
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5TFU
 | | Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex | | Descriptor: | (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Hsu, M.H, Johnson, E.F. | | Deposit date: | 2016-09-26 | | Release date: | 2017-01-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
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5THP
 | | Rhodocetin in complex with the integrin alpha2-A domain | | Descriptor: | CHLORIDE ION, GLYCEROL, Integrin alpha-2, ... | | Authors: | McDougall, M, Orriss, G.L, Stetefeld, J. | | Deposit date: | 2016-09-30 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.006 Å) | | Cite: | Dramatic and concerted conformational changes enable rhodocetin to block alpha 2 beta 1 integrin selectively.
PLoS Biol., 15, 2017
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5T63
 | | The HhoA protease from Synechocystis sp. PCC 6803 | | Descriptor: | ALA-ALA-ALA-ALA, MAGNESIUM ION, Putative serine protease HhoA | | Authors: | Persson, K, Hall, M, Funk, C. | | Deposit date: | 2016-09-01 | | Release date: | 2017-01-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation.
J. Struct. Biol., 198, 2017
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5T69
 | | The HhoA protease from Synechocystis sp. PCC 6803, active site mutant | | Descriptor: | ACETATE ION, MAGNESIUM ION, Putative serine protease HhoA | | Authors: | Persson, K, Hall, M, Funk, C. | | Deposit date: | 2016-09-01 | | Release date: | 2017-01-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation.
J. Struct. Biol., 198, 2017
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5T6D
 | | 2.10 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (hexagonal form) | | Descriptor: | 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide, Genome polyprotein | | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Kim, Y, Rathnayake, A.D, Damalanka, V.C, Weerawarna, P.M, Doyle, S.T, Alsoudi, A.F, Dissanayake, D.M.P, Chang, K.-O, Groutas, W.C. | | Deposit date: | 2016-09-01 | | Release date: | 2016-11-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
Eur J Med Chem, 126, 2016
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5T6J
 | | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | | Descriptor: | Kinetochore protein SPC24, Kinetochore protein SPC25, Kinetochore-associated protein DSN1 | | Authors: | Valverde, R, Jenni, S, Dimitrova, Y, Khin, Y, Harrison, S.C. | | Deposit date: | 2016-09-01 | | Release date: | 2016-11-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.752 Å) | | Cite: | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly.
Cell, 167, 2016
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5T5U
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5T8Q
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5T6F
 | | 1.90 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (orthorhombic P form) | | Descriptor: | 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide, Genome polyprotein | | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Kim, Y, Rathnayake, A.D, Damalanka, V.C, Weerawarna, P.M, Doyle, S.T, Alsoudi, A.F, Dissanayake, D.M.P, Chang, K.-O, Groutas, W.C. | | Deposit date: | 2016-09-01 | | Release date: | 2016-11-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
Eur J Med Chem, 126, 2016
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5T7S
 | | Crystal structure of galectin-8N in complex with Lactose | | Descriptor: | GLYCEROL, Galectin-8, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Bohari, M.H, Yu, X, Blanchard, H. | | Deposit date: | 2016-09-05 | | Release date: | 2017-01-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8.
Sci Rep, 6, 2016
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5TBD
 | | Crystal Structure of anti-MSP2 Fv fragment (mAb4D11) in complex with 3D7-MSP2 215-222 | | Descriptor: | Fv fragment (mAb4D1) heavy chain, Merozoite surface protein 2 | | Authors: | Seow, J, Morales, R.A.V, MacRaild, C.A, Bankala, K, Drinkwater, N, Dingjan, T, Jaipuria, G, Wilde, K, Anders, R.F, Atreya, H.S, Christ, D, McGowan, S, Norton, R.S. | | Deposit date: | 2016-09-12 | | Release date: | 2017-02-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.
J. Mol. Biol., 429, 2017
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5TBP
 | | Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | | Descriptor: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | | Deposit date: | 2016-09-12 | | Release date: | 2017-08-09 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
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