5T6D
2.10 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (hexagonal form)
Summary for 5T6D
Entry DOI | 10.2210/pdb5t6d/pdb |
Related | 5T6F 5T6G |
Descriptor | Genome polyprotein, 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide (3 entities in total) |
Functional Keywords | protease, norovirus, norwalk virus, antiviral inhibitors, dipeptidyl inhibitor, protease-protease inhibitor complex, protease/protease inhibitor |
Biological source | Norwalk virus (Hu/NV/NV/1968/US) |
Total number of polymer chains | 2 |
Total formula weight | 41331.63 |
Authors | Lovell, S.,Battaile, K.P.,Mehzabeen, N.,Kankanamalage, A.C.G.,Kim, Y.,Rathnayake, A.D.,Damalanka, V.C.,Weerawarna, P.M.,Doyle, S.T.,Alsoudi, A.F.,Dissanayake, D.M.P.,Chang, K.-O.,Groutas, W.C. (deposition date: 2016-09-01, release date: 2016-11-23, Last modification date: 2023-10-04) |
Primary citation | Galasiti Kankanamalage, A.C.,Kim, Y.,Rathnayake, A.D.,Damalanka, V.C.,Weerawarna, P.M.,Doyle, S.T.,Alsoudi, A.F.,Dissanayake, D.M.,Lushington, G.H.,Mehzabeen, N.,Battaile, K.P.,Lovell, S.,Chang, K.O.,Groutas, W.C. Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. Eur J Med Chem, 126:502-516, 2016 Cited by PubMed: 27914364DOI: 10.1016/j.ejmech.2016.11.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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