5T6D

2.10 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (hexagonal form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Genome polyprotein	polymer	188	20126.1	2	UniProt (Q83883)	Norwalk virus (Hu/NV/NV/1968/US)
2	C, D (A, B)	3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide	non-polymer		539.7	2	Chemie (N38)
3	E, F (A, B)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 1 - 181 (UniProt: Q83883)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40252.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1079.4
All*	Total formula weight	41331.6

*Water molecules are not included.