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8UYM	MERS 5' proximal stem-loop 5, conformation 3 Descriptor: MERS 5' proximal stem-loop 5 Authors: Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. Deposit date: 2023-11-13 Release date: 2023-12-06 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
8UYP	SARS-CoV-1 5' proximal stem-loop 5 Descriptor: SARS-CoV-1 5' proximal stem-loop 5 Authors: Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. Deposit date: 2023-11-13 Release date: 2023-12-20 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (7.1 Å) Cite: Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
8UYO	Structure of a recombinant human PNMA2 capsid Descriptor: Paraneoplastic antigen Ma2 Authors: Wilkinson, M.E, Madigan, V, Zhang, Y, Zhang, F. Deposit date: 2023-11-13 Release date: 2024-03-20 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery. Proc.Natl.Acad.Sci.USA, 121, 2024
8R3T	Cofactor-free Tau 4R2N isoform Descriptor: Microtubule-associated protein tau Authors: Limorenko, G, Tatli, M, Kolla, R, Nazarov, S, Weil, M.T, Schondorf, D.C, Geist, D, Reinhardt, P, Ehrnhoefer, D.E, Stahlberg, H, Gasparini, L, Lashuel, H.A. Deposit date: 2023-11-10 Release date: 2023-12-06 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nat Commun, 14, 2023
8R3V	Escherichia coli paused disome complex (non-rotated disome interface) Descriptor: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ... Authors: Fluegel, T, Schacherl, M. Deposit date: 2023-11-10 Release date: 2024-03-06 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nat Commun, 15, 2024
8R3K	Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A. Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, PYROPHOSPHATE 2-, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8R3L	Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8UX1	Cryo-EM structure of Ran bound to RCC1 and the nucleosome core particle Descriptor: 153-bp Widom 601 DNA forward strand, 153-bp Widom 601 DNA reverse strand, GTP-binding nuclear protein Ran, ... Authors: Huang, S.K, Rubinstein, J.L, Kay, L.E. Deposit date: 2023-11-08 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Cryo-EM structure of Ran bound to RCC1 and the nucleosome core particle To Be Published
8X1V	NMR structure of a bimolecular parallel G-quadruplex formed by AAGGG repeats from pathogenic RFC1 gene Descriptor: DNA (5'-D(*AP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*A)-3') Authors: Wang, Y, Guo, P, Han, D. Deposit date: 2023-11-08 Release date: 2024-01-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS. Nucleic Acids Res., 52, 2024
8X1H	Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 Descriptor: GLYCEROL, Nucleoprotein Authors: Kumari, S, Gupta, G.D. Deposit date: 2023-11-07 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2 To Be Published
8UW3	Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state Descriptor: Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ... Authors: Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E. Deposit date: 2023-11-06 Release date: 2023-12-20 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Template and target-site recognition by human LINE-1 in retrotransposition. Nature, 626, 2024
8X1C	Structure of nucleosome-bound SRCAP-C in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
8X15	Structure of nucleosome-bound SRCAP-C in the apo state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
8X19	Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. Deposit date: 2023-11-06 Release date: 2024-03-06 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
8X01	Structure of the Mumps Virus L Protein (state2) Bound by Phosphoprotein Tetramer Descriptor: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION Authors: Li, T.H, Shen, Q.T. Deposit date: 2023-11-02 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nat Commun, 15, 2024
8UV0	Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2 Authors: Deller, M.C, Epling, L.B. Deposit date: 2023-11-02 Release date: 2024-02-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67, 2024
8R1L	Structure of avian H5N1 influenza A polymerase in complex with human ANP32B. Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. Deposit date: 2023-11-02 Release date: 2024-05-08 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation. Nat Commun, 15, 2024
8R1J	Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. Deposit date: 2023-11-02 Release date: 2024-05-08 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation. Nat Commun, 15, 2024
8R1G	Dimeric ternary structure of E6AP-E6-p53 Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.99 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
8R1F	Monomeric E6AP-E6-p53 ternary complex Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
8UU4	Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU8	Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU5	Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UU6	Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
8UUA	Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III) Descriptor: 23S Ribosomal RNA, 5S Ribosomal RNA, GTPase HflX, ... Authors: Seely, S.M, Basu, R.S, Gagnon, M.G. Deposit date: 2023-10-31 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024

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