5OMP
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![BU of 5omp by Molmil](/molmil-images/mine/5omp) | Human FKBP5 protein | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION | Authors: | Kumar, R, Moche, M, Winblad, B, Pavlov, P. | Deposit date: | 2017-08-01 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
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5OBK
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![BU of 5obk by Molmil](/molmil-images/mine/5obk) | The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one | Descriptor: | (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Pomplun, S, Sippel, C, Haehle, A, Bracher, A, Hausch, F. | Deposit date: | 2017-06-28 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. J. Med. Chem., 61, 2018
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5NJX
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![BU of 5njx by Molmil](/molmil-images/mine/5njx) | Human FKBP51 protein in complex with C-terminal peptide of Human HSP 90-alpha | Descriptor: | HSP90AA1 protein, Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION | Authors: | Kumar, R, Moche, M, Winblad, B, Pavlov, P. | Deposit date: | 2017-03-30 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
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5MGX
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![BU of 5mgx by Molmil](/molmil-images/mine/5mgx) | |
5L1D
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![BU of 5l1d by Molmil](/molmil-images/mine/5l1d) | |
5KLX
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![BU of 5klx by Molmil](/molmil-images/mine/5klx) | |
5J6E
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![BU of 5j6e by Molmil](/molmil-images/mine/5j6e) | |
5I98
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![BU of 5i98 by Molmil](/molmil-images/mine/5i98) | |
5I7Q
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![BU of 5i7q by Molmil](/molmil-images/mine/5i7q) | |
5I7P
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![BU of 5i7p by Molmil](/molmil-images/mine/5i7p) | Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A,FKBP-type peptidyl-prolyl cis-trans isomerase SlyD,Peptidyl-prolyl cis-trans isomerase FKBP1A | Authors: | Jakob, R.P, Knappe, T.A, Dobbek, H, Schmid, F.X. | Deposit date: | 2016-02-18 | Release date: | 2017-03-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Structural and Functional Analysis of Chaperone Domain Insertion in Fkbp12 To Be Published
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5HWC
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![BU of 5hwc by Molmil](/molmil-images/mine/5hwc) | |
5HWB
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![BU of 5hwb by Molmil](/molmil-images/mine/5hwb) | |
5HW8
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![BU of 5hw8 by Molmil](/molmil-images/mine/5hw8) | |
5HW7
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![BU of 5hw7 by Molmil](/molmil-images/mine/5hw7) | |
5HW6
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![BU of 5hw6 by Molmil](/molmil-images/mine/5hw6) | |
5HUA
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![BU of 5hua by Molmil](/molmil-images/mine/5hua) | Structure of C. glabrata FKBP12-FK506 complex | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506-binding protein 1 | Authors: | Schumacher, M.A. | Deposit date: | 2016-01-27 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
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5HTG
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![BU of 5htg by Molmil](/molmil-images/mine/5htg) | |
5HT1
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![BU of 5ht1 by Molmil](/molmil-images/mine/5ht1) | Structure of apo C. glabrata FKBP12 | Descriptor: | FK506-binding protein 1 | Authors: | Schumacher, M.A. | Deposit date: | 2016-01-26 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
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5HKG
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![BU of 5hkg by Molmil](/molmil-images/mine/5hkg) | Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin: calstabin 2 (FKBP12.6). | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Sirigu, S, Huet, T, Bacchi, M, Jullian, M, Fould, B, Ferry, G, Vuillard, L, Chavas, L, Puget, K, Nosjean, O, Boutin, J.A. | Deposit date: | 2016-01-14 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6). Protein Sci., 25, 2016
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5GPG
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![BU of 5gpg by Molmil](/molmil-images/mine/5gpg) | Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR | Authors: | Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W. | Deposit date: | 2016-08-02 | Release date: | 2016-10-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells Acs Cent.Sci., 2, 2016
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5GL1
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![BU of 5gl1 by Molmil](/molmil-images/mine/5gl1) | Structure of RyR1 in an open state | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Bai, X.C, Yan, Z, Wu, J.P, Yan, N. | Deposit date: | 2016-07-07 | Release date: | 2016-08-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening Cell Res., 26, 2016
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5GL0
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![BU of 5gl0 by Molmil](/molmil-images/mine/5gl0) | Structure of RyR1 in a closed state (C4 conformer) | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Bai, X.C, Yan, Z, Wu, J.P, Yan, N. | Deposit date: | 2016-07-07 | Release date: | 2016-08-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening Cell Res., 26, 2016
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5GKZ
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![BU of 5gkz by Molmil](/molmil-images/mine/5gkz) | Structure of RyR1 in a closed state (C3 conformer) | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Bai, X.C, Yan, Z, Wu, J.P, Yan, N. | Deposit date: | 2016-07-07 | Release date: | 2016-08-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening Cell Res., 26, 2016
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5GKY
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![BU of 5gky by Molmil](/molmil-images/mine/5gky) | Structure of RyR1 in a closed state (C1 conformer) | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Bai, X.C, Yan, Z, Wu, J.P, Yan, N. | Deposit date: | 2016-07-07 | Release date: | 2016-08-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening Cell Res., 26, 2016
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5DIV
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![BU of 5div by Molmil](/molmil-images/mine/5div) | The Fk1 domain of FKBP51 in complex with the new synthetic ligand (S)-N-(1-carbamoylcyclopentyl)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxamide | Descriptor: | (2S)-N-(1-carbamoylcyclopentyl)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Gaali, S, Feng, X, Sippel, C, Bracher, A, Hausch, F. | Deposit date: | 2015-09-01 | Release date: | 2016-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. J.Med.Chem., 59, 2016
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