5OBK

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-((3,5-dichlorophenyl)sulfonyl)-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one

Summary for 5OBK

Entry DOI	10.2210/pdb5obk/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP5, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one (3 entities in total)
Functional Keywords	fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, isomerase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13451
Total number of polymer chains	1
Total formula weight	14510.47
Authors	Pomplun, S.,Sippel, C.,Haehle, A.,Bracher, A.,Hausch, F. (deposition date: 2017-06-28, release date: 2018-04-04, Last modification date: 2024-01-17)
Primary citation	Pomplun, S.,Sippel, C.,Hahle, A.,Tay, D.,Shima, K.,Klages, A.,Unal, C.M.,Riess, B.,Toh, H.T.,Hansen, G.,Yoon, H.S.,Bracher, A.,Preiser, P.,Rupp, J.,Steinert, M.,Hausch, F. Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. J. Med. Chem., 61:3660-3673, 2018 Cited by PubMed: 29578710 DOI: 10.1021/acs.jmedchem.8b00137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation