5HKG

Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin: calstabin 2 (FKBP12.6).

Summary for 5HKG

• Entry DOI: 10.2210/pdb5hkg/pdb
• Related: 1C9H
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: synthetic protein, refolding, immunophilin, isomerase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P68106
• Total number of polymer chains: 1
• Total formula weight: 12936.11

Authors

Sirigu, S.,Huet, T.,Bacchi, M.,Jullian, M.,Fould, B.,Ferry, G.,Vuillard, L.,Chavas, L.,Puget, K.,Nosjean, O.,Boutin, J.A. (deposition date: 2016-01-14, release date: 2016-10-05, Last modification date: 2024-01-10)

• Primary citation: Bacchi, M.,Jullian, M.,Sirigu, S.,Fould, B.,Huet, T.,Bruyand, L.,Antoine, M.,Vuillard, L.,Ronga, L.,Chavas, L.M.,Nosjean, O.,Ferry, G.,Puget, K.,Boutin, J.A.; Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6).; Protein Sci., 25:2225-2242, 2016; PubMed: 27670942; DOI: 10.1002/pro.3051

Experimental method

X-RAY DIFFRACTION (1.5 Å)