5HKG
Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin: calstabin 2 (FKBP12.6).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005528 | molecular_function | FK506 binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006457 | biological_process | protein folding |
| A | 0006458 | biological_process | 'de novo' protein folding |
| A | 0010459 | biological_process | negative regulation of heart rate |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0016020 | cellular_component | membrane |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0019855 | molecular_function | calcium channel inhibitor activity |
| A | 0030018 | cellular_component | Z disc |
| A | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| A | 0034704 | cellular_component | calcium channel complex |
| A | 0042026 | biological_process | protein refolding |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0050849 | biological_process | negative regulation of calcium-mediated signaling |
| A | 0051280 | biological_process | negative regulation of release of sequestered calcium ion into cytosol |
| A | 0051604 | biological_process | protein maturation |
| A | 0051775 | biological_process | response to redox state |
| A | 0060314 | biological_process | regulation of ryanodine-sensitive calcium-release channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue RAP A 201 |
| Chain | Residue |
| A | GLU5 |
| A | GLN53 |
| A | GLU54 |
| A | VAL55 |
| A | ILE56 |
| A | PHE59 |
| A | TYR82 |
| A | ASP100 |
| A | EDO205 |
| A | HOH317 |
| A | HOH326 |
| A | THR6 |
| A | HOH340 |
| A | HOH375 |
| A | HOH397 |
| A | TYR26 |
| A | THR27 |
| A | MET29 |
| A | LYS35 |
| A | PHE36 |
| A | ASP37 |
| A | PHE46 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 202 |
| Chain | Residue |
| A | HIS25 |
| A | ASN43 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 203 |
| Chain | Residue |
| A | LYS35 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | HOH442 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 205 |
| Chain | Residue |
| A | SER39 |
| A | ARG42 |
| A | LYS44 |
| A | PHE46 |
| A | LYS73 |
| A | RAP201 |
| A | HOH352 |
| A | HOH387 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 206 |
| Chain | Residue |
| A | THR14 |
| A | GLN20 |
| A | LEU68 |
| A | HOH301 |
| A | HOH303 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 207 |
| Chain | Residue |
| A | TYR82 |
| A | ALA84 |
| A | THR85 |
| A | EDO208 |
| A | HOH304 |
| A | HOH386 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 208 |
| Chain | Residue |
| A | PHE15 |
| A | PRO78 |
| A | ASP79 |
| A | GLY83 |
| A | ALA84 |
| A | ASN94 |
| A | EDO207 |
| A | HOH304 |
| A | HOH310 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
