PDB: 224004 resultsInfo pagesStatus searchChemie searchBIRD

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6EZ9	X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor JHU3372 Descriptor: (2~{S})-2-[[(2~{S})-4-methyl-1-oxidanyl-1-oxidanylidene-pentan-2-yl]oxycarbonylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barinka, C, Novakova, Z, Motlova, L. Deposit date: 2017-11-14 Release date: 2018-12-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors. Bioorg.Med.Chem., 27, 2019
7B0V	Crystal Structure of human monoamine oxidase B in complex with (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one Descriptor: (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Iacovino, L.G, Binda, C. Deposit date: 2020-11-23 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B. Acs Med.Chem.Lett., 12, 2021
7NTM	Cryo-EM structure of S.cerevisiae native alcohol dehydrogenase 1 (ADH1) in its tetrameric apo state Descriptor: Alcohol dehydrogenase 1, ZINC ION Authors: Nzigou Mandouckou, J.A, Carroni, M, Haeggstrom, J.Z, Thulasingam, M. Deposit date: 2021-03-10 Release date: 2022-10-12 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Cryo-EM structure of S.cerevisiae native alcohol dehydrogenase 1 (ADH1) in its tetrameric apo state To Be Published
3IKR	Crystal structure of alpha 1-4 mannobiose bound trimeric human lung surfactant protein D Descriptor: CALCIUM ION, Pulmonary surfactant-associated protein D, alpha-D-mannopyranose Authors: Shrive, A.K, Greenhough, T.J. Deposit date: 2009-08-06 Release date: 2009-11-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325 J.Mol.Biol., 394, 2009
6YJG	Crystal structure of MINDY1 mutant-Y114F Descriptor: Ubiquitin carboxyl-terminal hydrolase MINDY1 Authors: Abdul Rehman, S.A, Kulathu, Y. Deposit date: 2020-04-03 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.28 Å) Cite: Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell, 81, 2021
6YJE	Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from PEG3350 and ammonium acetate at pH 5.5 Descriptor: (2~{S})-2-(5-nitrofuran-2-yl)-2,3,5,6,7,8-hexahydro-1~{H}-[1]benzothiolo[2,3-d]pyrimidin-4-one, Phosphoglycerate kinase Authors: Blaszczyk, B.K, Hyvonen, M. Deposit date: 2020-04-03 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Phosphoglycerate Kinase as a potential target for antimalarial therapy to be published
8GAC	Crystal structure of a high affinity CTLA-4 binder Descriptor: 1,2-ETHANEDIOL, CTLA-4 binder Authors: Yang, W, Almo, S.C, Ghosh, A. Deposit date: 2023-02-22 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of a high affinity CTLA-4 binder To Be Published
8GAD	Crystal structure of a high affinity PD-L1 binder Descriptor: INDOLE, PD-L1 binder Authors: Yang, W, Almo, S.C, Ghosh, A. Deposit date: 2023-02-22 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal structure of a high affinity PD-L1 binder To Be Published
4X9H	Crystal structure of Dscam1 isoform 8.4, N-terminal four Ig domains Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform AP, ... Authors: Chen, Q. Deposit date: 2014-12-11 Release date: 2015-12-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv, 2, 2016
8GAB	Crystal structure of CTLA-4 in complex with a high affinity CTLA-4 binder Descriptor: CTLA-4 binder, Cytotoxic T-lymphocyte protein 4, POTASSIUM ION Authors: Yang, W, Almo, S.C, Ghosh, A. Deposit date: 2023-02-22 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Crystal structure of a high affinity CTLA-4 binder To Be Published
1BUF	SELF-COMPLEMENTARY DNA 5'-D(CAATTG)2, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: DNA (5'-D(*CP*AP*AP*TP*TP*G)-3') Authors: Lam, S.L, Au-Yeung, S.C.F. Deposit date: 1996-06-24 Release date: 1997-01-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Sequence-specific local structural variations in solution structures of d(CGXX'CG)2 and d(CAXX'TG)2 self-complementary deoxyribonucleic acids. J.Mol.Biol., 266, 1997
1BZ2	STABILIZATION OF THE ANTICODON STEM-LOOP OF TRNALYS,3 BY AN A+C BASE PAIR AND BY PSEUDOURIDINE, NMR, 1 STRUCTURE Descriptor: TRNA Authors: Durant, P.C, Davis, D.R. Deposit date: 1998-11-05 Release date: 1999-04-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Stabilization of the anticodon stem-loop of tRNALys,3 by an A+-C base-pair and by pseudouridine. J.Mol.Biol., 285, 1999
1C34	SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE Descriptor: DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3') Authors: Bolton, P.H, Marathias, V.M, Wang, K. Deposit date: 1999-07-24 Release date: 1999-08-18 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA. Nucleic Acids Res., 28, 2000
1BOH	SULFUR-SUBSTITUTED RHODANESE (ORTHORHOMBIC FORM) Descriptor: RHODANESE Authors: Gliubich, F, Berni, R, Cianci, M, Trevino, R.J, Horowitz, P.M, Zanotti, G. Deposit date: 1998-08-04 Release date: 1999-04-27 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: NH2-terminal sequence truncation decreases the stability of bovine rhodanese, minimally perturbs its crystal structure, and enhances interaction with GroEL under native conditions. J.Biol.Chem., 274, 1999
1BQ3	SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH INOSITOL HEXAKISPHOSPHATE Descriptor: INOSITOL HEXAKISPHOSPHATE, PROTEIN (PHOSPHOGLYCERATE MUTASE 1), SULFATE ION Authors: Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A. Deposit date: 1998-08-20 Release date: 1998-08-26 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis. J.Mol.Biol., 289, 1999
1BRW	THE CRYSTAL STRUCTURE OF PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE IN A CLOSED CONFORMATION Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, PHOSPHATE ION, ... Authors: Pugmire, M.J, Ealick, S.E. Deposit date: 1998-08-25 Release date: 1999-01-13 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation. Structure, 6, 1998
1BSJ	COBALT DEFORMYLASE INHIBITOR COMPLEX FROM E.COLI Descriptor: (S)-2-(PHOSPHONOXY)CAPROYL-L-LEUCYL-P-NITROANILIDE, COBALT (II) ION, PHOSPHATE ION, ... Authors: Hao, B, Gong, W, Rajagopalan, P.T, Hu, Y, Pei, D, Chan, M.K. Deposit date: 1998-08-28 Release date: 2000-04-15 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for the design of antibiotics targeting peptide deformylase. Biochemistry, 38, 1999
1BXC	XYLOSE ISOMERASE FROM THERMUS CALDOPHILUS Descriptor: XYLOSE ISOMERASE Authors: Chang, C, Park, B.C, Lee, D.-S, Suh, S.W. Deposit date: 1998-10-02 Release date: 1999-02-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability. J.Mol.Biol., 288, 1999
1BUI	Structure of the ternary microplasmin-staphylokinase-microplasmin complex: a proteinase-cofactor-substrate complex in action Descriptor: L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, Plasminogen, Staphylokinase Authors: Parry, M.A.A, Fernandez-Catalan, C, Bergner, A, Huber, R, Hopfner, K, Schlott, B, Guehrs, K, Bode, W. Deposit date: 1998-09-04 Release date: 1999-09-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.65 Å) Cite: The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action. Nat.Struct.Biol., 5, 1998
6PAB	E. coli L-asparaginase II in complex with L-Asp at pH 7.0 Descriptor: ASPARTIC ACID, CITRIC ACID, IMIDAZOLE, ... Authors: Lubkowski, J, Wlodawer, A. Deposit date: 2019-06-11 Release date: 2019-09-04 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019
1BLN	ANTI-P-GLYCOPROTEIN FAB MRK-16 Descriptor: PROTEIN (MONOCLONAL ANTIBODY MRK-16 (HEAVY CHAIN)), PROTEIN (MONOCLONAL ANTIBODY MRK-16 (LIGHT CHAIN)) Authors: Vasudevan, S, Tsuruo, T, Rose, D.R. Deposit date: 1998-07-16 Release date: 1998-10-28 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling study. J.Biol.Chem., 273, 1998
1C0Y	SOLUTION STRUCTURE OF THE [AF]-C8-DG ADDUCT POSITIONED OPPOSITE DA AT A TEMPLATE-PRIMER JUNCTION Descriptor: 2-AMINOFLUORENE, DNA (5'-D(*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*GP*GP*TP*AP*GP*C)-3') Authors: Gu, Z, Gorin, A, Hingerty, B.E, Broyde, S, Patel, D.J. Deposit date: 1999-07-19 Release date: 1999-08-31 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structures of aminofluorene [AF]-stacked conformers of the syn [AF]-C8-dG adduct positioned opposite dC or dA at a template-primer junction. Biochemistry, 38, 1999
1C2Q	SOLUTION STRUCTURE OF A DNA.RNA HYBRID CONTAINING AN ALPHAT-ANOMERIC THYMIDINE AND POLARITY REVERSALS Descriptor: 5'-D(ATGG-3'-3'-(T3P)-5'-5'-GCTC)-3', 5'-R(GAGCACCAU)-3' Authors: Germann, M.W, Aramini, J.M. Deposit date: 1999-07-26 Release date: 1999-11-29 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of a DNA.RNA hybrid containing an alpha-anomeric thymidine and polarity reversals: d(ATGG-3'-3'-alphaT-5'-5'-GCTC). r(gagcaccau). Biochemistry, 38, 1999
1BU4	RIBONUCLEASE 1 COMPLEX WITH 2'GMP Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 Authors: Loris, R, Devos, S, Langhorst, U, Decanniere, K, Bouckaert, J, Maes, D, Transue, T.R, Steyaert, J. Deposit date: 1998-09-11 Release date: 1999-02-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Conserved water molecules in a large family of microbial ribonucleases. Proteins, 36, 1999
1BK1	ENDO-1,4-BETA-XYLANASE C Descriptor: ENDO-1,4-B-XYLANASE C Authors: Fushinobu, S, Ito, K, Konno, M, Wakagi, T, Matsuzawa, H. Deposit date: 1998-07-14 Release date: 1999-01-13 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallographic and mutational analyses of an extremely acidophilic and acid-stable xylanase: biased distribution of acidic residues and importance of Asp37 for catalysis at low pH. Protein Eng., 11, 1998

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