7SIJ
| Myocilin OLF mutant E352K | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-14 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJV
| Myocilin OLF mutant T353I | Descriptor: | CALCIUM ION, Myocilin, C-terminal fragment, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-19 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKE
| Myocilin OLF mutant R296H | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKF
| Myocilin OLF mutant A445V | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.282 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJT
| Myocilin OLF mutant K398R | Descriptor: | CALCIUM ION, Myocilin, C-terminal fragment, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-19 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJW
| Myocilin OLF mutant L303I | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-19 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKG
| Myocilin OLF mutant V329M | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SIB
| Myocilin OLF mutant K500R | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-13 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKD
| Myocilin OLF mutant S331L | Descriptor: | CALCIUM ION, Myocilin, C-terminal fragment, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-10-20 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.712 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SP1
| RNA-induced tau amyloid fibril | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | Authors: | Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S. | Deposit date: | 2021-11-02 | Release date: | 2022-03-30 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7T8D
| Myocilin OLF mutant V449I | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | Deposit date: | 2021-12-16 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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8CYZ
| Crystal structure of SARS-CoV-2 Mpro with compound C4 | Descriptor: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-[4-(methylsulfanyl)phenyl]acetamide | Authors: | Worrall, L.J, Lee, J, Strynadka, N.C.J. | Deposit date: | 2022-05-24 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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8CZ7
| Crystal structure of SARS-CoV-2 Mpro with compound C2 | Descriptor: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide | Authors: | Worrall, L.J, Lee, J, Strynadka, N.C.J. | Deposit date: | 2022-05-24 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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8CYU
| Crystal structure of SARS-CoV-2 Mpro with compound C5 | Descriptor: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(isoquinolin-4-yl)acetamide | Authors: | Worrall, L.J, Lee, J, Strynadka, N.C.J. | Deposit date: | 2022-05-24 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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8CZ4
| Crystal structure of SARS-CoV-2 Mpro with compound C3 | Descriptor: | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide | Authors: | Worrall, L.J, Lee, J, Strynadka, N.C.J. | Deposit date: | 2022-05-24 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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7UMK
| Structure of vesicular stomatitis virus (helical reconstruction, 4.1 A resolution) | Descriptor: | Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. | Deposit date: | 2022-04-07 | Release date: | 2022-04-20 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle. Nat Commun, 13, 2022
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7UML
| Structure of vesicular stomatitis virus (local reconstruction, 3.5 A resolution) | Descriptor: | Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | Authors: | Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. | Deposit date: | 2022-04-07 | Release date: | 2022-04-20 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle. Nat Commun, 13, 2022
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5WMF
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5WYN
| HtrA2 Pathogenic Mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Serine protease HTRA2, ... | Authors: | Wagh, A.R, Bose, K. | Deposit date: | 2017-01-13 | Release date: | 2018-08-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2 Biosci. Rep., 38, 2018
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5W7C
| Human acyloxyacyl hydrolase (AOAH), proteolytically processed, S263A mutant, with LPS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-HYDROXY-TETRADECANOIC ACID, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6A0Z
| Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 13D4, Fab Heavy Chain, ... | Authors: | Li, S, Li, T. | Deposit date: | 2018-06-06 | Release date: | 2018-06-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.329 Å) | Cite: | Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol., 92, 2018
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6A0X
| Crystal structure of broadly neutralizing antibody 13D4 | Descriptor: | Antibody 13D4, Fab Heavy Chain, Fab Light Chain | Authors: | Li, S, Li, T. | Deposit date: | 2018-06-06 | Release date: | 2018-06-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol., 92, 2018
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4WXQ
| Crystal Structure of the Myocilin Olfactomedin Domain | Descriptor: | CALCIUM ION, HEXAETHYLENE GLYCOL, Myocilin, ... | Authors: | Orwig, S.D, Turnage, K.C, Donegan, R.K, Lieberman, R.L. | Deposit date: | 2014-11-14 | Release date: | 2015-04-01 | Last modified: | 2017-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural basis for misfolding in myocilin-associated glaucoma. Hum.Mol.Genet., 24, 2015
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4XEA
| Crystal structure of putative M16-like peptidase from Alicyclobacillus acidocaldarius | Descriptor: | ACETATE ION, GLYCEROL, NICKEL (II) ION, ... | Authors: | Michalska, K, Tesar, C, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-12-23 | Release date: | 2015-03-18 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of putative M16-like peptidase from Alicyclobacillus acidocaldarius To Be Published
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5LHR
| The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22 | Descriptor: | Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator | Authors: | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | Deposit date: | 2016-07-12 | Release date: | 2017-06-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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