9DJ9
 
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in distinct apo form | | Descriptor: | Dual specificity protein phosphatase 3 | | Authors: | Keedy, D.A, Lemberikman, A.M, Isiorho, E.A, Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2024-09-06 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (1.924 Å) | | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock
To Be Published
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2Q05
 | | Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR | | Descriptor: | Dual specificity protein phosphatase | | Authors: | Osipiuk, J, Skarina, T, Kagan, O, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-05-18 | | Release date: | 2007-06-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR.
To be Published
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5GTJ
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7NCY
 | | Dual specificity phosphatase from Sulfolobales Beppu filamentous virus 3 | | Descriptor: | Dual specificity phosphatase, GLYCEROL, NICKEL (II) ION | | Authors: | Welin, M, Akutsu, M, Hakansson, M, Al-Karadaghi, S, Jasilionis, A, Nordberg Karlsson, E. | | Deposit date: | 2021-01-29 | | Release date: | 2022-03-02 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dual specificity phosphatase from Sulfolobales Beppu filamentous virus 3
To Be Published
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4HRF
 | | Atomic structure of DUSP26 | | Descriptor: | Dual specificity protein phosphatase 26 | | Authors: | Lokareddy, R.K, Bhardwaj, A, Cingolani, G. | | Deposit date: | 2012-10-27 | | Release date: | 2013-01-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase.
Biochemistry, 52, 2013
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2Y96
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4R30
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6LMY
 | | Crystal structure of DUSP22 mutant_C88S/S93A | | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | | Authors: | Lai, C.H, Lyu, P.C. | | Deposit date: | 2019-12-27 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases.
Int J Mol Sci, 21, 2020
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6LOT
 | | Crystal structure of DUSP22 mutant_N128D | | Descriptor: | Dual specificity protein phosphatase 22, SULFATE ION | | Authors: | Lai, C.H, Lyu, P.C. | | Deposit date: | 2020-01-07 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases.
Int J Mol Sci, 21, 2020
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3LJ8
 | | Crystal Structure of MKP-4 | | Descriptor: | Tyrosine-protein phosphatase | | Authors: | Jeong, D.G, Yoon, T.S, Jung, S.-K, Park, H.S, Ryu, S.E, Kim, S.J. | | Deposit date: | 2010-01-26 | | Release date: | 2010-12-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4
Acta Crystallogr.,Sect.D, 67, 2011
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4WOH
 | | Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate | | Descriptor: | 1,2-ETHANEDIOL, 4-NITROPHENYL PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Lountos, G.T, Cherry, S, Tropea, J.E, Waugh, D.S. | | Deposit date: | 2014-10-15 | | Release date: | 2015-02-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate.
Acta Crystallogr.,Sect.F, 71, 2015
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5NCR
 | | OH1 from the Orf virus: a tyrosine phosphatase that displays distinct structural features and triple substrate specificity | | Descriptor: | PHOSPHATE ION, SULFATE ION, tyrosine phosphatase | | Authors: | Segovia, D, Haouz, A, Berois, M, Villarino, A, Andre-Leroux, G. | | Deposit date: | 2017-03-06 | | Release date: | 2017-08-09 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity.
J. Mol. Biol., 429, 2017
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5M43
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4Y2E
 | | Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S) | | Descriptor: | Dual specificity protein phosphatase 7, PHOSPHATE ION | | Authors: | Lountos, G.T, Austin, B.P, Tropea, J.E, Waugh, D.S. | | Deposit date: | 2015-02-09 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structure of human dual-specificity phosphatase 7, a potential cancer drug target.
Acta Crystallogr.,Sect.F, 71, 2015
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1MKP
 | | CRYSTAL STRUCTURE OF PYST1 (MKP3) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PYST1 | | Authors: | Stewart, A.E, Dowd, S, Keyse, S, Mcdonald, N.Q. | | Deposit date: | 1998-07-11 | | Release date: | 1999-07-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.
Nat.Struct.Biol., 6, 1999
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7EZN
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6I28
 | | Crystal Structure of Cydia Pomonella PTP-2 phosphatase | | Descriptor: | CALCIUM ION, GLYCEROL, ORF98 PTP-2 | | Authors: | Huang, G, Keown, J.P, Oliver, M.R, Metcalf, P. | | Deposit date: | 2018-10-31 | | Release date: | 2019-02-20 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus.
Acta Crystallogr.,Sect.F, 75, 2019
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4NYH
 | | Orthorhombic crystal form of pir1 dual specificity phosphatase core | | Descriptor: | CHLORIDE ION, PHOSPHATE ION, RNA/RNP complex-1-interacting phosphatase | | Authors: | Sankhala, R.S, Lokareddy, R.K, Cingolani, G. | | Deposit date: | 2013-12-10 | | Release date: | 2014-01-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase.
Biochemistry, 53, 2014
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7C8S
 | | Crystal structure of DUSP22 mutant_N128A | | Descriptor: | Dual specificity protein phosphatase 22, SULFATE ION | | Authors: | Lai, C.H, Lyu, P.C. | | Deposit date: | 2020-06-03 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases.
Int J Mol Sci, 21, 2020
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6L1S
 | | Crystal structure of DUSP22 mutant_C88S | | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | | Authors: | Lai, C.H, Chang, C.C, Lyu, P.C. | | Deposit date: | 2019-09-30 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.3611 Å) | | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases.
Int J Mol Sci, 21, 2020
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1M3G
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2R0B
 | | Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein | | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine/tyrosine-interacting protein | | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Iizuka, M, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-08-18 | | Release date: | 2007-08-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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1I9S
 | | CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME | | Descriptor: | CACODYLATE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | | Authors: | Changela, A, Ho, C.K, Martins, A, Shuman, S, Mondragon, A. | | Deposit date: | 2001-03-20 | | Release date: | 2001-05-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme.
EMBO J., 20, 2001
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2RF6
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1J4X
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE C124S MUTANT-PEPTIDE COMPLEX | | Descriptor: | DDE(AHP)(TPO)G(PTR)VATR, DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 | | Authors: | Schumacher, M.A, Todd, J.L, Tanner, K.G, Denu, J.M. | | Deposit date: | 2001-12-13 | | Release date: | 2001-12-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
Biochemistry, 41, 2002
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