5UGG
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![BU of 5ugg by Molmil](/molmil-images/mine/5ugg) | Protease Inhibitor | Descriptor: | Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen | Authors: | Law, R.H.P, Wu, G, Whisstock, J.C. | Deposit date: | 2017-01-08 | Release date: | 2017-05-31 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors. Blood Adv, 1, 2017
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6D3Y
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5UGD
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![BU of 5ugd by Molmil](/molmil-images/mine/5ugd) | Protease Inhibitor | Descriptor: | Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide, Plasminogen | Authors: | Law, R.H.P, Wu, G, Whisstock, J.C. | Deposit date: | 2017-01-08 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors. Blood Adv, 1, 2017
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6D40
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8F7U
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![BU of 8f7u by Molmil](/molmil-images/mine/8f7u) | Macrocyclic Plasmin Inhibitor | Descriptor: | (5S,8R,18S,21R)-N-{[4-(aminomethyl)phenyl]methyl}-21-[(benzenesulfonyl)amino]-3,11,20-trioxo-2,5,8,12,19-pentaazatetracyclo[21.2.2.2~5,8~.2~13,16~]hentriaconta-1(25),13,15,23,26,28-hexaene-18-carboxamide, Activation peptide, GLYCEROL, ... | Authors: | Guojie, W. | Deposit date: | 2022-11-20 | Release date: | 2023-02-08 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Synthesis and structural characterization of new macrocyclicplasmin inhibitors Chemmedchem, 2023
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7UAH
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![BU of 7uah by Molmil](/molmil-images/mine/7uah) | Macrocyclic plasmin inhibitor | Descriptor: | (2~{R})-butane-1,2-diol, (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(3-chlorobenzene-1-sulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, Plasminogen, ... | Authors: | Guojie, W. | Deposit date: | 2022-03-12 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors. Chemmedchem, 18, 2023
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8F7V
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![BU of 8f7v by Molmil](/molmil-images/mine/8f7v) | Macrocyclic plasmin inhibitor | Descriptor: | (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(benzenesulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, GLYCEROL, Plasminogen, ... | Authors: | Guojie, W. | Deposit date: | 2022-11-20 | Release date: | 2023-02-08 | Last modified: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Synthesis and structural characterization of new macrocyclicplasmin inhibitors Chemmedchem, 2023
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5HPG
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1KRN
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![BU of 1krn by Molmil](/molmil-images/mine/1krn) | STRUCTURE OF KRINGLE 4 AT 4C TEMPERATURE AND 1.67 ANGSTROMS RESOLUTION | Descriptor: | PLASMINOGEN, SULFATE ION | Authors: | Stec, B, Teeter, M.M, Whitlow, M, Yamano, A. | Deposit date: | 1995-06-21 | Release date: | 1997-01-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure of human plasminogen kringle 4 at 1.68 a and 277 K. A possible structural role of disordered residues. Acta Crystallogr.,Sect.D, 53, 1997
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6OG4
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![BU of 6og4 by Molmil](/molmil-images/mine/6og4) | plasminogen binding group A streptococcal M protein | Descriptor: | Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION | Authors: | Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T. | Deposit date: | 2019-04-01 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. J.Mol.Biol., 431, 2019
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1KI0
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![BU of 1ki0 by Molmil](/molmil-images/mine/1ki0) | The X-ray Structure of Human Angiostatin | Descriptor: | ANGIOSTATIN, BICINE | Authors: | Abad, M.C, Arni, R.K, Grella, D.K, Castellino, F.J, Tulinsky, A, Geiger, J.H. | Deposit date: | 2001-12-02 | Release date: | 2002-05-29 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. J.Mol.Biol., 318, 2002
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4CIK
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![BU of 4cik by Molmil](/molmil-images/mine/4cik) | plasminogen kringle 1 in complex with inhibitor | Descriptor: | 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN | Authors: | Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D. | Deposit date: | 2013-12-10 | Release date: | 2014-06-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction. Acs Med.Chem.Lett., 5, 2014
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7THS
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![BU of 7ths by Molmil](/molmil-images/mine/7ths) | Macrocyclic plasmin inhibitor | Descriptor: | (2S)-butane-1,2-diol, (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide, Plasminogen, ... | Authors: | Guojie, W. | Deposit date: | 2022-01-12 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors. Chemmedchem, 18, 2023
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6D3X
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1PK4
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7E50
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![BU of 7e50 by Molmil](/molmil-images/mine/7e50) | Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI | Descriptor: | AAEL006007-PA, GLYCEROL, Plasminogen, ... | Authors: | Varsha, A.W, Jobichen, C, Mok, Y.K. | Deposit date: | 2021-02-16 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci., 31, 2022
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1DDJ
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![BU of 1ddj by Molmil](/molmil-images/mine/1ddj) | CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN | Descriptor: | PLASMINOGEN | Authors: | Wang, X, Terzyan, S, Tang, J, Loy, J, Lin, X, Zhang, X. | Deposit date: | 1999-11-10 | Release date: | 2000-02-18 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. J.Mol.Biol., 295, 2000
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6D3Z
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![BU of 6d3z by Molmil](/molmil-images/mine/6d3z) | Protease SFTI complex | Descriptor: | Plasminogen, Trypsin inhibitor 1 | Authors: | Law, R.H.P, Wu, G. | Deposit date: | 2018-04-17 | Release date: | 2019-01-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62, 2019
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1QRZ
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![BU of 1qrz by Molmil](/molmil-images/mine/1qrz) | CATALYTIC DOMAIN OF PLASMINOGEN | Descriptor: | PLASMINOGEN | Authors: | Peisach, E, Wang, J, de los Santos, T, Reich, E, Ringe, D. | Deposit date: | 1999-06-16 | Release date: | 1999-10-14 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the proenzyme domain of plasminogen. Biochemistry, 38, 1999
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4DCB
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![BU of 4dcb by Molmil](/molmil-images/mine/4dcb) | Y. pestis Plasminogen Activator Pla in Complex with Human Plasminogen Activation Loop Peptide ALP11 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ... | Authors: | Eren, E, van den Berg, B. | Deposit date: | 2012-01-17 | Release date: | 2012-06-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Structural basis for activation of an integral membrane protease by lipopolysaccharide. J.Biol.Chem., 287, 2012
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1CEA
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1CEB
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2PK4
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1PMK
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2DOH
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![BU of 2doh by Molmil](/molmil-images/mine/2doh) | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Angiostatin, Plasminogen-binding group A streptococcal M-like protein PAM | Authors: | Cnudde, S.E, Prorok, M, Castellino, F.J, Geiger, J.H. | Deposit date: | 2006-04-29 | Release date: | 2006-12-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM Biochemistry, 45, 2006
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