PDB: 213 件ウェブページステータス検索Chemie searchBIRD

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4AUV	Crystal Structure of the BRMS1 N-terminal region 分子名称: ACETIC ACID, BREAST CANCER METASTASIS SUPPRESSOR 1, CHLORIDE ION, ... 著者 Spinola-Amilibia, M, Rivera, J, Ortiz-Lombardia, M, Romero, A, Neira, J.L, Bravo, J. 登録日 2012-05-22 公開日 2013-03-20 最終更新日 2019-11-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Brms151-98 and Brms151-84 are Crystal Oligomeric Coiled Coils with Different Oligomerization States, which Behave as Disordered Protein Fragments in Solution. J.Mol.Biol., 425, 2013
7Z8Z	Crystal structure of the MEILB2-BRME1 2:2 core complex 分子名称: Break repair meiotic recombinase recruitment factor 1, Heat shock factor 2-binding protein 著者 Gurusaran, M, Davies, O.R. 登録日 2022-03-19 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MEILB2-BRME1 acts as a DNA clamp upon dimerisation induced by BRCA2-binding in meiotic recombination. To Be Published
8A51	Crystal structure of HSF2BP-BRME1 complex 分子名称: 1,2-ETHANEDIOL, Break repair meiotic recombinase recruitment factor 1, CHLORIDE ION, ... 著者 Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S. 登録日 2022-06-13 公開日 2023-07-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination. Sci Adv, 9, 2023
2XUS	Crystal Structure of the BRMS1 N-terminal region 分子名称: BREAST CANCER METASTASIS-SUPPRESSOR 1, CHLORIDE ION, SULFATE ION 著者 Spinola-Amilibia, M, Rivera, J, Ortiz-Lombardia, M, Romero, A, Neira, J.L, Bravo, J. 登録日 2010-10-20 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 The Structure of Brms1 Nuclear Export Signal and Snx6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils. J.Mol.Biol., 411, 2011
8QJT	BRM (SMARCA2) Bromodomain in complex with ligand 10 分子名称: 2-[6-azanyl-5-[(1R,5S)-8-[2-(2-methoxyethoxy)pyridin-4-yl]-3,8-diazabicyclo[3.2.1]octan-3-yl]pyridazin-3-yl]phenol, CHLORIDE ION, Probable global transcription activator SNF2L2, ... 著者 Kerry, P.S, Hole, A.J, Perez-Dorado, J.I. 登録日 2023-09-13 公開日 2024-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.568 Å) 主引用文献 PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J.Med.Chem., 67, 2024
6EG3	Crystal structure of human BRM in complex with compound 15 分子名称: 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2 著者 Zhu, X, Kulathila, R, Hu, T, Xie, X. 登録日 2018-08-17 公開日 2018-10-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
6EG2	Crystal structure of human BRM in complex with compound 16 分子名称: ISOPROPYL ALCOHOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea 著者 Zhu, X, Kulathila, R, Hu, T, Xie, X. 登録日 2018-08-17 公開日 2018-10-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
8QJS	VHL/Elongin B/Elongin C complex with compound 155 分子名称: (2S,4R)-1-[(2R)-2-[3-[2-(2-methoxyethoxy)ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Kerry, P.S, Hole, A.J, Perez-Dorado, J.I. 登録日 2023-09-13 公開日 2024-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.191 Å) 主引用文献 PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J.Med.Chem., 67, 2024
8QJR	BRG1 bromodomain in complex with VBC via compound 17 分子名称: (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, CHLORIDE ION, Elongin-B, ... 著者 Kerry, P.S, Hole, A.J, Perez-Dorado, J.I. 登録日 2023-09-13 公開日 2024-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J.Med.Chem., 67, 2024
5DKC	Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe 分子名称: (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one, Probable global transcription activator SNF2L2, ZINC ION 著者 Tallant, C, Owen, D.R, Gerstenberger, B.S, Fedorov, O, Savitsky, P, Nunez-Alonso, G, Fonseca, M, Krojer, T, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Muller, S, Knapp, S. 登録日 2015-09-03 公開日 2015-10-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe To Be Published
5DKH	Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17 分子名称: (2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one, 1,2-ETHANEDIOL, Probable global transcription activator SNF2L2, ... 著者 Tallant, C, Owen, D.R, Taylor, A, Fedorov, O, Savitsky, P, Siejka, P, Srikannathasan, V, Nowak, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S. 登録日 2015-09-03 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17 To Be Published
7TAB	G-925 bound to the SMARCA4 (BRG1) Bromodomain 分子名称: 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1 著者 Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. 登録日 2021-12-20 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65, 2022
7TD9	G-059 bound to the SMARCA4 (BRG1) Bromodomain 分子名称: 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1 著者 Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. 登録日 2021-12-30 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65, 2022
8A50	Crystal structure of HSF2BP-ALPHA1 tetramer 分子名称: Heat shock factor 2-binding protein, PHOSPHATE ION 著者 Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S. 登録日 2022-06-13 公開日 2023-07-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.484 Å) 主引用文献 BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination. Sci Adv, 9, 2023
6CGE	Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+ 分子名称: 3-{[(14beta,16alpha,17alpha)-3-(2-bromoethyl)-17-hydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Li, T, Lin, S.X. 登録日 2018-02-20 公開日 2019-01-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide. J Phys Chem Lett, 9, 2018
1GL3	ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE IN COMPLEX WITH NADP AND SUBSTRATE ANALOGUE S-METHYL CYSTEINE SULFOXIDE 分子名称: ASPARTATE-SEMIALDEHYDE DEHYDROGENASE, CYSTEINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hadfield, A.T, Kryger, G, Ouyang, J, Ringe, D, Petsko, G.A, Viola, R.E. 登録日 2001-08-23 公開日 2001-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Active Site Analysis of the Potential Antimicrobial Target Aspartate Semialdehyde Dehydrogenase. Biochemistry, 40, 2001
1BRM	ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE FROM ESCHERICHIA COLI 分子名称: ASPARTATE-SEMIALDEHYDE DEHYDROGENASE 著者 Hadfield, A.T, Kryger, G, Ouyang, J, Ringe, D, Petsko, G.A, Viola, R.E. 登録日 1998-08-24 公開日 1999-06-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. J.Mol.Biol., 289, 1999
7BRM	Architecture of curli complex 分子名称: Curli production assembly/transport protein CsgG, csgf 著者 Zhang, M, Shi, H. 登録日 2020-03-29 公開日 2020-07-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae. Plos Biol., 18, 2020
6BRM	The crystal structure of isothiocyanate hydrolase from Delia radicum gut bacteria 分子名称: FORMIC ACID, Putative metal-dependent isothiocyanate hydrolase SaxA, ZINC ION 著者 Tan, K, van den Bosch, T, Joachimiak, A, Welte, C. 登録日 2017-11-30 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria. Appl. Environ. Microbiol., 84, 2018
3BRM	Crystal structure of the covalent complex between the Bacillus subtilis glutaminase YbgJ and 5-oxo-L-norleucine formed by reaction of the protein with 6-diazo-5-oxo-L-norleucine 分子名称: 5-OXO-L-NORLEUCINE, Glutaminase 1 著者 Singer, A.U, Kim, Y, Dementieva, I, Vinokour, E, Joachimiak, A, Savchenko, A, Yakunin, A. 登録日 2007-12-21 公開日 2008-05-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis. Biochemistry, 47, 2008
5BRM	Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling 分子名称: MOB kinase activator 1A, Serine/threonine-protein kinase 3, ZINC ION 著者 Luo, X, Ni, L. 登録日 2015-05-31 公開日 2015-07-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.651 Å) 主引用文献 Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Genes Dev., 29, 2015
8BRM	Giardia ribosome in POST-T state, no E-site tRNA (A6) 分子名称: 5.8S rRNA, 5S rRNA, Large Subunit rRNA, ... 著者 Majumdar, S, Emmerich, A.G, Sanyal, S. 登録日 2022-11-23 公開日 2023-03-15 最終更新日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
2BRM	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 分子名称: 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Foloppe, N, Fisher, L.M, Howes, R, Kierstan, P, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2005-05-09 公開日 2005-05-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity. J.Med.Chem., 48, 2005
5BRK	pMob1-Lats1 complex 分子名称: MOB kinase activator 1A, Serine/threonine-protein kinase LATS1, ZINC ION 著者 Ni, L, Luo, X. 登録日 2015-05-31 公開日 2015-07-08 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Genes Dev., 29, 2015
4BRM	Sulfur SAD phasing of the Legionella pneumophila NTPDase1 - crystal form III (closed) in complex with sulfate 分子名称: CHLORIDE ION, ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE I, SULFATE ION 著者 Zebisch, M, Schaefer, P, Lauble, P, Straeter, N. 登録日 2013-06-04 公開日 2013-07-17 最終更新日 2013-12-25 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Crystallographic Snapshots Along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases Structure, 21, 2013

 

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