5DKC

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe

Summary for 5DKC

• Entry DOI: 10.2210/pdb5dkc/pdb
• Descriptor: Probable global transcription activator SNF2L2, ZINC ION, (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one, ... (4 entities in total)
• Functional Keywords: swi-snf complex, chromatin remodeling, brg associated factors (baf), transcription, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P51531
• Total number of polymer chains: 1
• Total formula weight: 14767.32

Authors

Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S. (deposition date: 2015-09-03, release date: 2015-10-14, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S.; Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)