PDB: 82 件ウェブページステータス検索Chemie searchBIRD

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1HWW	GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R. 登録日 2001-01-10 公開日 2002-01-10 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. EMBO J., 20, 2001
3LVT	The Crystal Structure of a Protein in the Glycosyl Hydrolase Family 38 from Enterococcus faecalis to 2.55A 分子名称: CALCIUM ION, Glycosyl hydrolase, family 38 著者 Stein, A.J, Binkowski, T.A, Weger, A, Borovilos, M, Moy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2010-02-22 公開日 2010-03-16 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The Crystal Structure of a Protein in the Glycosyl Hydrolase Family 38 from Enterococcus faecalis to 2.55A To be Published
6LZ1	Structure of S.pombe alpha-mannosidase Ams1 分子名称: Ams1, ZINC ION 著者 Zhang, J, Ye, K. 登録日 2020-02-17 公開日 2020-09-09 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure of fission yeast tetrameric alpha-mannosidase Ams1. Febs Open Bio, 10, 2020
7VQO	Cryo-EM structure of Ams1 bound to the FW domain of Nbr1 分子名称: Ams1, Nbr1 and malE fusion protein, ZINC ION 著者 Zhang, J, Ye, K. 登録日 2021-10-20 公開日 2022-07-06 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.19 Å) 主引用文献 Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1 Nat Commun, 13, 2022
7DD9	Cryo-EM structure of the Ams1 and Nbr1 complex 分子名称: Alpha-mannosidase,ZZ-type zinc finger-containing protein P35G2.11c,Maltose/maltodextrin-binding periplasmic protein, ZINC ION 著者 Zhang, J, Ye, K. 登録日 2020-10-28 公開日 2021-07-14 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1. Embo J., 40, 2021
2ALW	Golgi alpha-mannosidase II complex with Noeuromycin 分子名称: (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Bols, M.B, Liu, H, Rose, D.R. 登録日 2005-08-08 公開日 2006-07-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The role of the active site Zn in the catalytic mechanism of the GH38 Golgi alpha-mannosidase II: implications from noeuromycin inhibition Biocatal.Biotransfor., 34, 2006
6B9O	Structure of GH 38 Jack Bean alpha-mannosidase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase from Canavalia ensiformis (jack bean), ZINC ION, ... 著者 Howard, E, Cousido-Siah, A, Lepage, M, Bodlenner, A, Mitschler, A, Meli, A, De Riccardis, F, Izzo, I, Podjarny, A, Compain, P. 登録日 2017-10-11 公開日 2018-09-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.841 Å) 主引用文献 Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition. Angew. Chem. Int. Ed. Engl., 57, 2018
6B9P	Structure of GH 38 Jack Bean alpha-mannosidase in complex with a 36-valent iminosugar cluster inhibitor 分子名称: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-{9-[4-(methoxymethyl)-1H-1,2,3-triazol-1-yl]nonyl}piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase from Canavalia ensiformis (jack bean), ... 著者 Howard, E, Cousido-Siah, A, Lepage, M, Bodlenner, A, Mitschler, A, Meli, A, De Riccardis, F, Izzo, I, Podjarny, A, Compain, P. 登録日 2017-10-11 公開日 2018-09-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition. Angew. Chem. Int. Ed. Engl., 57, 2018
5JM0	Structure of the S. cerevisiae alpha-mannosidase 1 分子名称: Alpha-mannosidase,Alpha-mannosidase,Alpha-mannosidase 著者 Schneider, S, Kosinski, J, Jakobi, A.J, Hagen, W.J.H, Sachse, C. 登録日 2016-04-28 公開日 2016-06-15 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle. Embo Rep., 17, 2016
2WYH	Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALPHA-MANNOSIDASE, GLYCEROL, ... 著者 Suits, M.D.L, Zhu, Y, Taylor, E.J, Zechel, D.L, Gilbert, H.J, Davies, G.J. 登録日 2009-11-16 公開日 2010-02-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Kinetic Investigation of Streptococcus Pyogenes Family Gh38 Alpha-Mannosidase Plos One, 5, 2010
5KBP	The crystal structure of an alpha-mannosidase from Enterococcus faecalis V583 分子名称: Glycosyl hydrolase, family 38, SULFATE ION 著者 Tan, K, Chhor, G, Jedrzejczak, R, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-06-03 公開日 2016-07-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The crystal structure of an alpha-mannosidase from Enterococcus faecalis V583 To Be Published
2WYI	Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase complexed with swainsonine 分子名称: 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, 2-(2-METHOXYETHOXY)ETHANOL, ALPHA-MANNOSIDASE, ... 著者 Suits, M.D.L, Zhu, Y, Taylor, E.J, Zechel, D.L, Gilbert, H.J, Davies, G.J. 登録日 2009-11-16 公開日 2010-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and Kinetic Investigation of Streptococcus Pyogenes Family Gh38 Alpha-Mannosidase Plos One, 5, 2010
2OW7	Golgi alpha-mannosidase II complex with (1R,6S,7R,8S)-1-thioniabicyclo[4.3.0]nonan-7,8-diol chloride 分子名称: (1R,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-7,8-DIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A. 登録日 2007-02-15 公開日 2008-01-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding. Proteins, 71, 2008
1HTY	GOLGI ALPHA-MANNOSIDASE II 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R. 登録日 2001-01-02 公開日 2002-01-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. EMBO J., 20, 2001
1HXK	GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1-DEOXYMANNOJIRIMYCIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 van den Elsen, J.M.H, Kuntz, D.A, Rose, D.R. 登録日 2001-01-16 公開日 2002-01-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. EMBO J., 20, 2001
2OW6	Golgi alpha-mannosidase II complex with (1r,5s,6s,7r,8s)-1-thioniabicyclo[4.3.0]nonan-5,7,8-triol chloride 分子名称: (1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A. 登録日 2007-02-15 公開日 2008-01-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding. Proteins, 71, 2008
3D50	GOLGI MANNOSIDASE II complex with N-octyl-6-epi-valienamine 分子名称: (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Tarling, C.A, Withers, S.G, Rose, D.R. 登録日 2008-05-15 公開日 2008-08-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Biochemistry, 47, 2008
3D4Y	GOLGI MANNOSIDASE II complex with mannoimidazole 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ... 著者 Kuntz, D.A, Tarling, C.A, Withers, S.G, Rose, D.R. 登録日 2008-05-15 公開日 2008-08-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Biochemistry, 47, 2008
6RRH	GOLGI ALPHA-MANNOSIDASE II 分子名称: 1,2-ETHANEDIOL, Alpha-mannosidase 2, ZINC ION 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
3DDF	GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one 分子名称: (3R,4R,5R)-3,4-dihydroxy-5-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidin-2-one, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... 著者 Kuntz, D.A, Rose, D.R, Hoffman, D. 登録日 2008-06-05 公開日 2008-07-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site Bioorg.Med.Chem., 16, 2008
6RQZ	GOLGI ALPHA-MANNOSIDASE II complex with Manno-epi-cyclophellitol aziridine 分子名称: (1~{R},2~{S},3~{R},4~{R},5~{S},6~{R})-5-azanyl-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, Debets, M, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-16 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRW	GOLGI ALPHA-MANNOSIDASE II in complex with (2R,3R,4R,5S)-1-(5-{[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy}pentyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol 分子名称: (2~{R},3~{R},4~{R},5~{S})-1-[5-[[4-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol, Alpha-mannosidase 2, ZINC ION 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
7UFR	Cryo-EM Structure of Bl_Man38A at 2.7 A 分子名称: Alpha-mannosidase, ZINC ION 著者 Santos, C.R, Cordeiro, R.L, Domingues, M.N, Borges, A.C, de Farias, M.A, Van Heel, M, Murakami, M.T, Portugal, R.V. 登録日 2022-03-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Cryo-EM Structure of Bl_Man38A at 2.7 A Nat.Chem.Biol., 2022
7UFU	Cryo-EM Structure of Bl_Man38A nucleophile mutant in complex with mannose at 2.7 A 分子名称: Alpha-mannosidase, ZINC ION, alpha-D-mannopyranose 著者 Santos, C.R, Cordeiro, R.L, Domingues, M.N, Borges, A.C, de Farias, M.A, Van Heel, M, Murakami, M.T, Portugal, R.V. 登録日 2022-03-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Cryo-EM Structure of Bl_Man38A nucleophile mutant in complex with mannose at 2.7 A Nat.Chem.Biol., 2022
7UFS	Cryo-EM Structure of Bl_Man38B at 3.4 A 分子名称: Alpha-mannosidase, ZINC ION 著者 Santos, C.R, Cordeiro, R.L, Domingues, M.N, Borges, A.C, de Farias, M.A, Van Heel, M, Murakami, M.T, Portugal, R.V. 登録日 2022-03-23 公開日 2022-11-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM Structure of Bl_Man38B at 3.4 A Nat.Chem.Biol., 2022

 

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