PDB: 74 件ウェブページステータス検索Chemie searchBIRD

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7KP4	Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain 分子名称: Claudin-4, Heat-labile enterotoxin B chain 著者 Vecchio, A.J, Stroud, R.M. 登録日 2020-11-10 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut. Proc.Natl.Acad.Sci.USA, 118, 2021
4P79	Crystal structure of mouse claudin-15 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Claudin-15 著者 Suzuki, H, Nishizawa, T, Tani, K, Yamazaki, Y, Tamura, A, Ishitani, R, Dohmae, N, Tsukita, S, Nureki, O, Fujiyoshi, Y. 登録日 2014-03-26 公開日 2014-04-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of a claudin provides insight into the architecture of tight junctions. Science, 344, 2014
6AKF	Crystal structure of mouse claudin-3 P134A mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin 分子名称: Claudin-3, Heat-labile enterotoxin B chain 著者 Nakamura, S, Irie, K, Fujiyoshi, Y. 登録日 2018-08-31 公開日 2019-02-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
3X29	CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN 分子名称: Claudin-19, Heat-labile enterotoxin B chain 著者 Saitoh, Y, Suzuki, H, Tani, K, Nishikawa, K, Irie, K, Ogura, Y, Tamura, A, Tsukita, S, Fujiyoshi, Y. 登録日 2014-12-13 公開日 2015-01-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin Science, 347, 2015
6AKG	Crystal structure of mouse claudin-3 P134G mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin 分子名称: Claudin-3, Heat-labile enterotoxin B chain 著者 Nakamura, S, Irie, K, Fujiyoshi, Y. 登録日 2018-08-31 公開日 2019-02-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
6AKE	Crystal structure of mouse claudin-3 in complex with C-terminal fragment of Clostridium perfringens enterotoxin 分子名称: Claudin-3, Heat-labile enterotoxin B chain 著者 Nakamura, S, Irie, K, Fujiyoshi, Y. 登録日 2018-08-31 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun, 10, 2019
7TDN	CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain 分子名称: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ... 著者 Vecchio, A.J. 登録日 2022-01-01 公開日 2022-02-09 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
7TDM	CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain 分子名称: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ... 著者 Vecchio, A.J. 登録日 2022-01-01 公開日 2022-02-09 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
8U5B	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1 分子名称: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ... 著者 Vecchio, A.J. 登録日 2023-09-12 公開日 2023-09-27 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (5.3 Å) 主引用文献 Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin To be published
8U4V	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody 分子名称: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ... 著者 Vecchio, A.J. 登録日 2023-09-11 公開日 2023-10-25 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin To be published
6OV2	Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form 分子名称: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain 著者 Vecchio, A.J, Stroud, R.M. 登録日 2019-05-06 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proc.Natl.Acad.Sci.USA, 116, 2019
6OV3	Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form 分子名称: Claudin-9, Heat-labile enterotoxin B chain 著者 Vecchio, A.J, Stroud, R.M. 登録日 2019-05-06 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proc.Natl.Acad.Sci.USA, 116, 2019
5B2G	Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin 分子名称: Endolysin,Claudin-4, Heat-labile enterotoxin B chain 著者 Shinoda, T, Kimura-Someya, T, Shirouzu, M, Yokoyama, S. 登録日 2016-01-15 公開日 2016-10-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin Sci Rep, 6, 2016
7QHB	Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... 著者 Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. 登録日 2021-12-11 公開日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
7QHH	Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... 著者 Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. 登録日 2021-12-12 公開日 2022-02-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
6DM0	Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6DM1	Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6DLZ	Open state GluA2 in complex with STZ after micelle signal subtraction 分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit 著者 Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. 登録日 2018-06-04 公開日 2018-08-22 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
6QKZ	Full length GluA1/2-gamma8 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ... 著者 Herguedas, B, Garcia-Nafria, J, Greger, I.G. 登録日 2019-01-30 公開日 2019-03-27 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
6QKC	GluA1/2 In complex with auxiliary subunit gamma-8 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ... 著者 Herguedas, B, Garcia-Nafria, J, Greger, I.G. 登録日 2019-01-28 公開日 2019-03-27 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
5KBU	Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid 著者 Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. 登録日 2016-06-03 公開日 2016-07-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
5KBS	Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid 著者 Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. 登録日 2016-06-03 公開日 2016-07-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.7 Å) 主引用文献 Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
5KBT	Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid 著者 Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. 登録日 2016-06-03 公開日 2016-07-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science, 353, 2016
5KK2	Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy 分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit 著者 Zhao, Y, Chen, S, Yoshioka, C, Baconguis, I, Gouaux, E. 登録日 2016-06-20 公開日 2016-07-06 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (7.3 Å) 主引用文献 Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. Nature, 536, 2016
8AYM	Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ... 著者 Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. 登録日 2022-09-02 公開日 2023-04-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023

 

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