PDB: 86 件ウェブページステータス検索Chemie searchBIRD

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6R1R	RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
7RW6	BORF2-APOBEC3Bctd Complex 分子名称: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION 著者 Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. 登録日 2021-08-19 公開日 2022-04-27 最終更新日 2022-05-04 実験手法 ELECTRON MICROSCOPY (2.55 Å) 主引用文献 Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Sci Adv, 8, 2022
5TUS	Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule 分子名称: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Mohammed, F.A, Alam, I, Dealwis, C.G. 登録日 2016-11-07 公開日 2017-08-02 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4X3V	Crystal structure of human ribonucleotide reductase 1 bound to inhibitor 分子名称: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE 著者 Dealwis, C.G, Ahmad, M.F, Alam, I. 登録日 2014-12-01 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58, 2015
7R1R	RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
5R1R	RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
7AGJ	Ribonucleotide Reductase R1 protein from Aquifex aeolicus 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Rehling, D, Scaletti, E.R, Stenmark, P. 登録日 2020-09-22 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus. Biochemistry, 61, 2022
1RLR	STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1 分子名称: RIBONUCLEOTIDE REDUCTASE PROTEIN R1 著者 Uhlin, U, Eklund, H. 登録日 1994-08-12 公開日 1996-12-23 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of ribonucleotide reductase protein R1. Nature, 370, 1994
5IM3	Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 著者 Johansson, R, Logan, D.T. 登録日 2016-03-05 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones. Structure, 24, 2016
4R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 分子名称: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ... 著者 Eriksson, M, Eklund, H. 登録日 1997-07-22 公開日 1998-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
2R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE 著者 Eriksson, M, Eklund, H. 登録日 1997-07-21 公開日 1998-01-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
6L3R	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide 分子名称: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-10-15 公開日 2020-10-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6L7L	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide 分子名称: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-11-01 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.171 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6AUI	Human ribonucleotide reductase large subunit (alpha) with dATP and CDP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. 登録日 2017-09-01 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
2ZLF	The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase 分子名称: FTLDADF, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. 登録日 2008-04-09 公開日 2008-08-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
3O0Q	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosine 分子名称: ADENOSINE, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
3O0O	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, COBALAMIN, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
6CGM	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free) 分子名称: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGL	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4) 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7) 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2XO4	RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 分子名称: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA 著者 Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. 登録日 2010-08-09 公開日 2010-08-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2XO5	RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 分子名称: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA 著者 Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. 登録日 2010-08-09 公開日 2010-08-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2ZLG	The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase 分子名称: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. 登録日 2008-04-09 公開日 2008-08-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
3O0N	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP and Adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, CHLORIDE ION, COBALAMIN, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. 登録日 2010-10-19 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (6.61 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011

 

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