7CIO
 
 | | Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase | | 分子名称: | Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha | | 著者 | Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. | | 登録日 | 2020-07-08 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
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2YU7
 | | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A | | 著者 | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-05 | | 公開日 | 2008-04-15 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published
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2YSX
 | | Solution structure of the human SHIP SH2 domain | | 分子名称: | Signaling inositol polyphosphate phosphatase SHIP II | | 著者 | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-04 | | 公開日 | 2008-04-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the human SHIP SH2 domain
To be Published
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5MTN
 | | Monobody Mb(Lck_1) bound to Lck-Sh2 | | 分子名称: | Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck | | 著者 | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | | 登録日 | 2017-01-10 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
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5MTJ
 | | Yes1-SH2 in complex with monobody Mb(Yes_1) | | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... | | 著者 | Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. | | 登録日 | 2017-01-09 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
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5MTM
 | | Monobody Mb(Lck_3) bound to Lck-SH2 domain | | 分子名称: | Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION | | 著者 | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | | 登録日 | 2017-01-10 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
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5JN0
 | | CRK-II SH2 domain | | 分子名称: | CHLORIDE ION, CRK-II SH2 domain | | 著者 | Cho, J.-H. | | 登録日 | 2016-04-29 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.677 Å) | | 主引用文献 | CRK-II SH2 domain
To Be Published
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4WWQ
 | | Apo structure of the Grb7 SH2 domain | | 分子名称: | Growth factor receptor-bound protein 7, MALONIC ACID | | 著者 | Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. | | 登録日 | 2014-11-12 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
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4X6S
 | | Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | | 分子名称: | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 | | 著者 | Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. | | 登録日 | 2014-12-09 | | 公開日 | 2015-09-23 | | 最終更新日 | 2015-10-28 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
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5KAZ
 | | Human SH2D1B structure | | 分子名称: | SH2 domain-containing protein 1B, SULFATE ION | | 著者 | Taha, M, Nezerwa, E, Nam, H.-J. | | 登録日 | 2016-06-02 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
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6R5G
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6ROZ
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6ROY
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6SM5
 | | MbC/SHP1-C-SH2 complex | | 分子名称: | MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 | | 著者 | Mann, G, Hantschel, O. | | 登録日 | 2019-08-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | MbC/SHP1-C-SH2 complex
To Be Published
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4ROJ
 | | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide | | 分子名称: | Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2014-10-28 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
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4TZI
 | | Structure of unliganded Lyn SH2 domain | | 分子名称: | Tyrosine-protein kinase Lyn | | 著者 | Wybenga-Groot, L.E. | | 登録日 | 2014-07-10 | | 公開日 | 2015-01-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.
Mol.Cell Proteomics, 14, 2015
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4U1P
 | | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | | 分子名称: | Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... | | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | | 登録日 | 2014-07-16 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
To Be Published
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4U17
 | | Swapped dimer of the human Fyn-SH2 domain | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn | | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | | 登録日 | 2014-07-15 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Swapped dimer of the human Fyn-SH2 domain
To Be Published
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6PXC
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6PXB
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5VKL
 | | SPT6 tSH2-RPB1 1476-1500 pS1493 | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 | | 著者 | Sdano, M.A, Whitby, F.G, Hill, C.P. | | 登録日 | 2017-04-21 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.
Elife, 6, 2017
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6E8M
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6E8I
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6E8H
 | | Legionella Longbeachae LeSH (Llo2327) | | 分子名称: | CHLORIDE ION, LeSH (Llo2327) | | 著者 | Kaneko, T, Li, S.S.C. | | 登録日 | 2018-07-29 | | 公開日 | 2018-11-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
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6E8K
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