PDB: 595 件ウェブページステータス検索Chemie searchBIRD

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5W3R	SH2B1 SH2 Domain 分子名称: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 著者 McKercher, M.A, Wuttke, D.S. 登録日 2017-06-08 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.386 Å) 主引用文献 Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
4WWQ	Apo structure of the Grb7 SH2 domain 分子名称: Growth factor receptor-bound protein 7, MALONIC ACID 著者 Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. 登録日 2014-11-12 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
4X6S	Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide 分子名称: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 著者 Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. 登録日 2014-12-09 公開日 2015-09-23 最終更新日 2015-10-28 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
6PXC	N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP 著者 Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. 登録日 2019-07-25 公開日 2019-12-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
7CIO	Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase 分子名称: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha 著者 Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2020-07-08 公開日 2020-12-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
3WA4	Grb2 SH2 domain/CD28-derived peptide complex 分子名称: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... 著者 Higo, K, Oda, M, Ito, N. 登録日 2013-04-23 公開日 2014-02-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
2IUH	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide 分子名称: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2021-04-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-28 公開日 2010-12-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
2YSX	Solution structure of the human SHIP SH2 domain 分子名称: Signaling inositol polyphosphate phosphatase SHIP II 著者 Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-04 公開日 2008-04-08 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human SHIP SH2 domain To be Published
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV 分子名称: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
2IUG	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2IUI	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2021-04-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide 分子名称: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide 分子名称: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION 著者 Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7WFY	Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide 分子名称: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2 著者 Zhang, Y.J, Liu, Y.R, Wu, B. 登録日 2021-12-27 公開日 2022-12-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.449 Å) 主引用文献 Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep, 12, 2022
6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl 分子名称: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-24 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
2YU7	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A 分子名称: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A 著者 Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-05 公開日 2008-04-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5EEL	Grb7 SH2 with bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... 著者 Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide 分子名称: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
5KAZ	Human SH2D1B structure 分子名称: SH2 domain-containing protein 1B, SULFATE ION 著者 Taha, M, Nezerwa, E, Nam, H.-J. 登録日 2016-06-02 公開日 2017-04-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett., 23, 2016
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide 分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
5MTN	Monobody Mb(Lck_1) bound to Lck-Sh2 分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck 著者 Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-10 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017

 

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