5W3R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w3r by Molmil](/molmil-images/mine/5w3r) | SH2B1 SH2 Domain | 分子名称: | PHENOL, PHOSPHATE ION, SH2B adapter protein 1 | 著者 | McKercher, M.A, Wuttke, D.S. | 登録日 | 2017-06-08 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.386 Å) | 主引用文献 | Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
|
|
4WWQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wwq by Molmil](/molmil-images/mine/4wwq) | Apo structure of the Grb7 SH2 domain | 分子名称: | Growth factor receptor-bound protein 7, MALONIC ACID | 著者 | Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-11-12 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
|
|
4X6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x6s by Molmil](/molmil-images/mine/4x6s) | Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | 分子名称: | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 | 著者 | Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-12-09 | 公開日 | 2015-09-23 | 最終更新日 | 2015-10-28 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
|
|
6PXC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pxc by Molmil](/molmil-images/mine/6pxc) | |
7CIO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cio by Molmil](/molmil-images/mine/7cio) | Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase | 分子名称: | Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha | 著者 | Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. | 登録日 | 2020-07-08 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
|
|
3WA4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wa4 by Molmil](/molmil-images/mine/3wa4) | Grb2 SH2 domain/CD28-derived peptide complex | 分子名称: | ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... | 著者 | Higo, K, Oda, M, Ito, N. | 登録日 | 2013-04-23 | 公開日 | 2014-02-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
|
|
2IUH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2iuh by Molmil](/molmil-images/mine/2iuh) | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide | 分子名称: | C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | 著者 | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | 登録日 | 2006-06-03 | 公開日 | 2006-06-06 | 最終更新日 | 2021-04-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
|
|
3N8M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n8m by Molmil](/molmil-images/mine/3n8m) | |
2YSX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ysx by Molmil](/molmil-images/mine/2ysx) | Solution structure of the human SHIP SH2 domain | 分子名称: | Signaling inositol polyphosphate phosphatase SHIP II | 著者 | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-04 | 公開日 | 2008-04-08 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the human SHIP SH2 domain To be Published
|
|
3N7Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n7y by Molmil](/molmil-images/mine/3n7y) | |
2IUG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2iug by Molmil](/molmil-images/mine/2iug) | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain | 分子名称: | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | 著者 | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | 登録日 | 2006-06-03 | 公開日 | 2006-06-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
|
|
2IUI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2iui by Molmil](/molmil-images/mine/2iui) | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta | 著者 | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | 登録日 | 2006-06-03 | 公開日 | 2006-06-06 | 最終更新日 | 2021-04-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
|
|
7T1K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t1k by Molmil](/molmil-images/mine/7t1k) | Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
|
|
7T1L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t1l by Molmil](/molmil-images/mine/7t1l) | Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide | 分子名称: | CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
|
|
7T1U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t1u by Molmil](/molmil-images/mine/7t1u) | Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION | 著者 | Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
|
|
7WFY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wfy by Molmil](/molmil-images/mine/7wfy) | |
6WO2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wo2 by Molmil](/molmil-images/mine/6wo2) | |
2YU7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yu7 by Molmil](/molmil-images/mine/2yu7) | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A | 分子名称: | Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A | 著者 | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-05 | 公開日 | 2008-04-15 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
|
|
5EEQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eeq by Molmil](/molmil-images/mine/5eeq) | Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor | 分子名称: | Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION | 著者 | Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. | 登録日 | 2015-10-23 | 公開日 | 2016-06-15 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
|
|
5EEL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eel by Molmil](/molmil-images/mine/5eel) | Grb7 SH2 with bicyclic peptide inhibitor | 分子名称: | Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... | 著者 | Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. | 登録日 | 2015-10-23 | 公開日 | 2016-06-15 | 最終更新日 | 2018-12-26 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
|
|
6E8M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e8m by Molmil](/molmil-images/mine/6e8m) | |
5KAZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kaz by Molmil](/molmil-images/mine/5kaz) | Human SH2D1B structure | 分子名称: | SH2 domain-containing protein 1B, SULFATE ION | 著者 | Taha, M, Nezerwa, E, Nam, H.-J. | 登録日 | 2016-06-02 | 公開日 | 2017-04-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett., 23, 2016
|
|
6E8H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e8h by Molmil](/molmil-images/mine/6e8h) | Legionella Longbeachae LeSH (Llo2327) | 分子名称: | CHLORIDE ION, LeSH (Llo2327) | 著者 | Kaneko, T, Li, S.S.C. | 登録日 | 2018-07-29 | 公開日 | 2018-11-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
|
|
6E8K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e8k by Molmil](/molmil-images/mine/6e8k) | |
5MTN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mtn by Molmil](/molmil-images/mine/5mtn) | Monobody Mb(Lck_1) bound to Lck-Sh2 | 分子名称: | Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck | 著者 | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | 登録日 | 2017-01-10 | 公開日 | 2017-04-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
|
|