PDB: 9 件ウェブページステータス検索Chemie searchBIRD

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4MZV	Crystal structure of extracellular part of human EpCAM 分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, Epithelial cell adhesion molecule 著者 Pavsic, M, Guncar, G, Djinovic-Carugo, K, Lenarcic, B. 登録日 2013-09-30 公開日 2014-08-27 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.865 Å) 主引用文献 Crystal structure and its bearing towards an understanding of key biological functions of EpCAM. Nat Commun, 5, 2014
6I07	Crystal structure of EpCAM in complex with scFv 分子名称: Epithelial cell adhesion molecule, GLYCEROL, Single chain Fv 著者 Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G. 登録日 2018-10-25 公開日 2019-03-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116, 2019
7PEE	Crystal structure of extracellular part of human Trop2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... 著者 Pavsic, M. 登録日 2021-08-09 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM. Int J Mol Sci, 22, 2021
6HYG	Heteromeric tandem IgG4/IgG1 Fc 分子名称: IgHG1 and IgHG4 hybrid, ZINC ION 著者 Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G. 登録日 2018-10-21 公開日 2019-03-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116, 2019
6I04	Crystal structure of Sema domain of the Met receptor in complex with FAB 分子名称: Fab heavy chain, Fab light chain, Hepatocyte growth factor receptor 著者 Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G. 登録日 2018-10-25 公開日 2019-03-13 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116, 2019
6R9H	Crystal structure of the PDZ tandem of syntenin in complex with fragment C58 分子名称: (2~{S})-2-[2-(4-chlorophenyl)sulfanylethanoylamino]-3-methyl-butanoic acid, ACETATE ION, PHOSPHATE ION, ... 著者 Feracci, M, Barral, K. 登録日 2019-04-03 公開日 2021-02-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10, 2020
6RLC	Crystal structure of the PDZ tandem of syntenin in complex with fragment F13 分子名称: (2~{S})-2-[3-(4-chlorophenyl)sulfanylpropanoylamino]-3-methyl-butanoic acid, ACETATE ION, Syntenin-1 著者 Feracci, M, Barral, K. 登録日 2019-05-02 公開日 2021-02-03 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10, 2020
4DZ8	human IgG1 Fc fragment Heterodimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region 著者 Strop, P. 登録日 2012-02-29 公開日 2012-08-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair. J.Mol.Biol., 420, 2012
5J8H	Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase 分子名称: CALCIUM ION, Calmodulin, Eukaryotic elongation factor 2 kinase 著者 Alphonse, S, Lee, K, Piserchio, A, Tavares, C.D.J, Giles, D.H, Wellmann, R.M, Dalby, K.N, Ghose, R. 登録日 2016-04-07 公開日 2016-09-07 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure, 24, 2016