6I04
Crystal structure of Sema domain of the Met receptor in complex with FAB
Summary for 6I04
Entry DOI | 10.2210/pdb6i04/pdb |
Descriptor | Hepatocyte growth factor receptor, Fab heavy chain, Fab light chain (3 entities in total) |
Functional Keywords | immune system, met, sema domain |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 219995.70 |
Authors | Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. (deposition date: 2018-10-25, release date: 2019-03-13, Last modification date: 2024-01-24) |
Primary citation | Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116:7533-7542, 2019 Cited by PubMed: 30898885DOI: 10.1073/pnas.1819085116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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