6I04

Crystal structure of Sema domain of the Met receptor in complex with FAB

Summary for 6I04

DescriptorHepatocyte growth factor receptor, Fab heavy chain, Fab light chain (3 entities in total)
Functional Keywordsimmune system, met, sema domain
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total molecular weight219995.7
Authors
Primary citation
Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovsjoy, A.A.,MacBeath, G.
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2613 0.4% 5.9% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6i04
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Molmil generated image of 6i04
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Molmil generated image of 6i04
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More Biological unit images

Molmil generated image of 6i04
no rotation
Molmil generated image of 6i04
rotated about x axis by 90°
Molmil generated image of 6i04
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6i04.pdb2.gz [139.43 KB])
Coordinate files for Biological unit (6i04.pdb1.gz [141.44 KB])