PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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1ONR	STRUCTURE OF TRANSALDOLASE B 分子名称: TRANSALDOLASE B 著者 Jia, J, Huang, W, Lindqvist, Y, Schneider, G. 登録日 1996-08-13 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family. Structure, 4, 1996
2G44	Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-1M-G and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide 分子名称: 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 著者 Rajan, S.S, Hsieh, R.W, Sharma, S.K, Greene, G.L. 登録日 2006-02-21 公開日 2007-01-09 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery and characterization of novel estrogen receptor agonist ligands and development of biochips for nuclear receptor drug discovery Thesis, 2006
1I6H	RNA POLYMERASE II ELONGATION COMPLEX 分子名称: 5'-D(P*AP*AP*AP*TP*GP*CP*CP*TP*GP*GP*TP*CP*T)-3', 5'-R(P*GP*AP*CP*CP*AP*GP*GP*CP*A)-3', DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, ... 著者 Gnatt, A.L, Cramer, P, Kornberg, R.D. 登録日 2001-03-02 公開日 2001-04-23 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science, 292, 2001
1OH0	CRYSTAL STRUCTURE OF KETOSTEROID ISOMERASE COMPLEXED WITH EQUILENIN 分子名称: BETA-MERCAPTOETHANOL, EQUILENIN, STEROID DELTA-ISOMERASE 著者 Kim, K.-H, Cha, S.-S, Byun, M, Oh, B.-H. 登録日 2003-05-21 公開日 2003-06-04 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 High-Resolution Crystal Structures of Delta5-3-Ketosteroid Isomerase with and without a Reaction Intermediate Analogue Biochemistry, 36, 1997
1AOG	TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE (OXIDIZED FORM) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, MALEIC ACID, TRYPANOTHIONE REDUCTASE 著者 Bond, C.S, Zhang, Y, Hunter, W.N. 登録日 1997-07-03 公開日 1997-09-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution. Protein Sci., 5, 1996
1HMP	THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP 分子名称: GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERASE 著者 Eads, J.C, Scapin, G, Xu, Y, Grubmeyer, C, Sacchettini, J.C. 登録日 1994-06-03 公開日 1995-06-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. Cell(Cambridge,Mass.), 78, 1994
2C1A	Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino) ethyl)amide 分子名称: CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE 著者 Collins, I, Caldwell, J, Fonseca, T, Donald, A, Bavetsias, V, Hunter, L.J, Garrett, M.D, Rowlands, M.G, Aherne, G.W, Davies, T.G, Berdini, V, Woodhead, S.J, Seavers, L.C.A, Wyatt, P.G, Workman, P, McDonald, E. 登録日 2005-09-12 公開日 2005-11-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. Bioorg. Med. Chem., 14, 2006
6HHI	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 30b 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-3-(propanoylamino)benzamide 著者 Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. 登録日 2018-08-28 公開日 2019-02-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
3N4B	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor 分子名称: 4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Avvaru, B.S, Wagner, J, Robbins, A.H, McKenna, R. 登録日 2010-05-21 公開日 2011-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chem.Commun.(Camb.), 46, 2010
8FN0	CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator 分子名称: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
3O7L	Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex 分子名称: Cardiac phospholamban, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... 著者 Cheng, C.Y, Taylor, S.S. 登録日 2010-07-30 公開日 2010-10-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dynamics connect substrate recognition to catalysis in protein kinase A. Nat.Chem.Biol., 6, 2010
9BCX	Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5 DNA entry gate 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA (39-MER), ... 著者 Yuan, Z, Bai, L, Li, H, Speck, C. 登録日 2024-04-10 公開日 2025-01-01 最終更新日 2025-01-15 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis. Nat Commun, 16, 2025
1OVT	REFINED CRYSTALLOGRAPHIC STRUCTURE OF HEN OVOTRANSFERRIN AT 2.4 ANGSTROMS RESOLUTION 分子名称: CARBONATE ION, FE (III) ION, OVOTRANSFERRIN 著者 Kurokawa, H, Mikami, B, Hirose, M. 登録日 1995-04-28 公開日 1995-09-15 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of diferric hen ovotransferrin at 2.4 A resolution. J.Mol.Biol., 254, 1995
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.993 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
3GDH	Methyltransferase domain of human Trimethylguanosine Synthase 1 (TGS1) bound to m7GTP and adenosyl-homocysteine (active form) 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, R-1,2-PROPANEDIOL, S-1,2-PROPANEDIOL, ... 著者 Monecke, T, Dickmanns, A, Ficner, R. 登録日 2009-02-24 公開日 2009-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res., 37, 2009
3UKL	Crystal structure of UDP-galactopyranose mutase from Aspergillus fumigatus in complex with UDP 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, UDP-galactopyranose mutase, ... 著者 Van Straaten, K.E, Sanders, D.A.R. 登録日 2011-11-09 公開日 2012-02-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus. J.Biol.Chem., 287, 2012
1AUR	PMSF-INHIBITED CARBOXYLESTERASE FROM PSEUDOMONAS FLUORESCENS 分子名称: CARBOXYLESTERASE, phenylmethanesulfonic acid 著者 Kim, K.K, Song, H.K, Suh, S.W. 登録日 1997-09-01 公開日 1998-03-04 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha/beta hydrolase with broad substrate specificity. Structure, 5, 1997
3UMI	X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc 分子名称: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ... 著者 Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E. 登録日 2011-11-13 公開日 2012-01-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain. J.Mol.Biol., 416, 2012
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 分子名称: CARBONIC ANHYDRASE II 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
7JV9	Human CD73 (ecto 5'-nucleotidase) in complex with compound 12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, 6-chloro-N-[(2-chlorophenyl)methyl]-1-[5-O-(phosphonomethyl)-beta-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... 著者 Gibbons, P, Du, X. 登録日 2020-08-20 公開日 2020-09-23 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63, 2020
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
3MH7	HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues 分子名称: 5-mer peptide, Protease do 著者 Krojer, T, Sawa, J, Huber, R, Clausen, T. 登録日 2010-04-07 公開日 2010-06-30 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.961 Å) 主引用文献 HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
1ZWA	STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES 分子名称: PARATHYROID HORMONE 著者 Roesch, P, Marx, U.C. 登録日 1996-06-17 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000
1ATX	THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 分子名称: ATX IA 著者 Billeter, M, Widmer, H, Wuthrich, K. 登録日 1990-05-14 公開日 1991-04-15 最終更新日 2024-10-16 実験手法 SOLUTION NMR 主引用文献 Three-dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution determined by nuclear magnetic resonance spectroscopy. Proteins, 6, 1989
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996

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