7XXE
 
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5CMQ
 | | Crystal Structure of Zn-bound Human H-Ferritin variant 122H-delta C-star | | 分子名称: | Ferritin heavy chain, ZINC ION | | 著者 | Sontz, P.A, Bailey, J.B, Ahn, S, Tezcan, F.A. | | 登録日 | 2015-07-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.935 Å) | | 主引用文献 | A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.
J.Am.Chem.Soc., 137, 2015
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8E0B
 | | Crystal structure of human Sar1bT39N | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, Sar1bT39N | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.212 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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5CI7
 | | Structure of ULK1 bound to a selective inhibitor | | 分子名称: | GLYCEROL, N-[3-({4-[(3-aminopropyl)amino]-5-iodopyrimidin-2-yl}amino)phenyl]pyrrolidine-1-carboxamide, Serine/threonine-protein kinase ULK1 | | 著者 | Lazarus, M.B, Shokat, K.M. | | 登録日 | 2015-07-11 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Bioorg.Med.Chem., 23, 2015
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8E0C
 | | Crystal structure of human Sar1bH79G | | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.993 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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6C5R
 | | Crystal structure of the soluble domain of the mitochondrial calcium uniporter | | 分子名称: | calcium uniporter | | 著者 | Fan, C, Fan, M, Fastman, N, Zhang, J, Feng, L. | | 登録日 | 2018-01-16 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.09608316 Å) | | 主引用文献 | X-ray and cryo-EM structures of the mitochondrial calcium uniporter.
Nature, 559, 2018
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1YIL
 | | Structure of Hen egg white lysozyme soaked with Cu2-Xylylbicyclam | | 分子名称: | 1,1'-[1,4-PHENYLENEBIS(METHYLENE)]BIS[1,4,8,11-TETRAAZA-CYCLOTETRADECANE]CU(II)2, CHLORIDE ION, Lysozyme C, ... | | 著者 | Hunter, T.M, McNae, I.W, Liang, X, Bella, J, Parsons, S, Walkinshaw, M.D, Sadler, P.J. | | 登録日 | 2005-01-12 | | 公開日 | 2005-02-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme
Proc.Natl.Acad.Sci.Usa, 102, 2005
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4PGU
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4KIG
 | | Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with 4-hydroxyphenylpyruvic acid | | 分子名称: | (2R)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROPANOIC ACID, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, CALCIUM ION, ... | | 著者 | Liu, Y.C, Zou, X.W, Chan, H.C, Huang, C.J, Li, T.L. | | 登録日 | 2013-05-02 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D, 70, 2014
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5CMR
 | | Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star | | 分子名称: | Ferritin heavy chain, N,N'-dihydroxybenzene-1,4-dicarboxamide, SODIUM ION, ... | | 著者 | Sontz, P.A, Bailey, J.B, Ahn, S, Tezcan, F.A. | | 登録日 | 2015-07-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.792 Å) | | 主引用文献 | A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.
J.Am.Chem.Soc., 137, 2015
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4QME
 | | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe | | 分子名称: | (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | | 著者 | Nocek, B, Vassilious, S, Mulligan, R, Berlicki, L, Mucha, A, Joachimiak, A. | | 登録日 | 2014-06-16 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
J.Med.Chem., 57, 2014
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4KOA
 | | Crystal Structure Analysis of 1,5-anhydro-D-fructose reductase from Sinorhizobium meliloti | | 分子名称: | 1,5-anhydro-D-fructose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Schu, M, Faust, A, Stosik, B, Kohring, G.-W, Giffhorn, F, Scheidig, A.J. | | 登録日 | 2013-05-11 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | The structure of substrate-free 1,5-anhydro-D-fructose reductase from Sinorhizobium meliloti 1021 reveals an open enzyme conformation.
Acta Crystallogr.,Sect.F, 69, 2013
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4QK3
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4GMV
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5ACZ
 | | COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 11MER CHICKEN PEPTIDE | | 分子名称: | 1,2-ETHANEDIOL, 11MER PEPTIDE, BETA-2-MICROGLOBULIN, ... | | 著者 | Chappell, P.E, Roversi, P, Harrison, M.C, Kaufman, J.F, Lea, S.M. | | 登録日 | 2015-08-19 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Complex of a B21 Chicken Mhc Class I Molecule and a 11mer Chicken Peptide
To be Published
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3QT0
 | | Revealing a steroid receptor ligand as a unique PPARgamma agonist | | 分子名称: | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, Nuclear receptor coactivator 1 peptide, Peroxisome proliferator-activated receptor gamma | | 著者 | Rong, H. | | 登録日 | 2011-02-22 | | 公開日 | 2012-02-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.496 Å) | | 主引用文献 | Revealing a steroid receptor ligand as a unique PPAR gamma agonist.
Cell Res., 22, 2012
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4FWV
 | | Crystal structure of the N-terminal domain of the Lon-like protease MtaLonC | | 分子名称: | SULFATE ION, TTC1975 peptidase | | 著者 | Chang, C.I, Li, J.K, Kuo, C.I, Huang, K.F. | | 登録日 | 2012-07-02 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones
Acta Crystallogr.,Sect.D, 69, 2013
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6B91
 | | Crystal structure of the N-terminal domain of human METTL16 | | 分子名称: | 1,2-ETHANEDIOL, SODIUM ION, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase | | 著者 | Ruszkowska, A, Ruszkowski, M, Dauter, Z, Brown, J.A. | | 登録日 | 2017-10-09 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural insights into the RNA methyltransferase domain of METTL16.
Sci Rep, 8, 2018
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8DTY
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5WK9
 | | R186AP450cam with CN and camphor | | 分子名称: | CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... | | 著者 | Poulos, T.L, Batabyal, D. | | 登録日 | 2017-07-24 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.983 Å) | | 主引用文献 | Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics.
J. Am. Chem. Soc., 139, 2017
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6BAB
 | | The structure of human CamKII with bound inhibitor | | 分子名称: | Calcium/calmodulin-dependent protein kinase type II subunit delta, L(+)-TARTARIC ACID, N-[(2S)-2-(diethylamino)propyl]-2-(3-hydroxyazetidin-1-yl)-6-[5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridine-4-carboxamide | | 著者 | Somoza, J.R, Villasenor, A.G. | | 登録日 | 2017-10-12 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | TBD
To Be Published
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4QS7
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5WK3
 | | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB | | 分子名称: | C-C motif chemokine 17, GLYCEROL, M116 HEAVY CHAIN, ... | | 著者 | Teplyakov, A, Obmolova, G, Gilliland, G.L. | | 登録日 | 2017-07-24 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights into chemokine CCL17 recognition by antibody M116.
Biochem Biophys Rep, 13, 2018
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8DVV
 | | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | 著者 | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | | 登録日 | 2022-07-29 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions
To Be Published
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5A0A
 | | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile, ... | | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | | 登録日 | 2015-04-17 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
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