PDB: 45118 件ウェブページステータス検索Chemie searchBIRD

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6NKZ	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma methylene dGTP 分子名称: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*TP*(2DT))-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
2ORH	Directing Macromolecular Conformation Through Halogen Bonds 分子名称: DNA (5'-D(*CP*CP*GP*AP*TP*AP*CP*CP*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*TP*AP*(DU)P*CP*GP*G)-3'), SODIUM ION 著者 Voth, A.R, Hays, F.A, Ho, P.S. 登録日 2007-02-02 公開日 2007-03-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Directing macromolecular conformation through halogen bonds. Proc.Natl.Acad.Sci.Usa, 104, 2007
5MIM	Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n 分子名称: 1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidine, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Guan-Sheng, J, Than, M.E. 登録日 2016-11-28 公開日 2017-05-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. ACS Chem. Biol., 12, 2017
6TTK	Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DVL1, ... 著者 Chen, Z, Williams, E, Pike, A.C.W, Strain-Damerell, C, Wang, D, Chalk, R, Burgess-Brown, N, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. 登録日 2019-12-27 公開日 2020-02-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.383 Å) 主引用文献 Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. Open Biology, 10, 2020
6NAX	Olfactomedin domain of mouse myocilin 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Patterson-Orazem, A.C, Hill, S.E, Lieberman, R.L. 登録日 2018-12-06 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.551 Å) 主引用文献 Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice. Biochemistry, 58, 2019
4H4I	OYE1-W116V complexed with the dismutation product of (S)-carvone 分子名称: 2-methyl-5-(prop-1-en-2-yl)phenol, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ... 著者 Pompeu, Y.A, Stewart, J.D. 登録日 2012-09-17 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 X-ray Crystallography Reveals How Subtle Changes Control the Orientation of Substrate Binding in an Alkene Reductase ACS CATALYSIS, 3, 2013
420D	CRYSTAL STRUCTURE OF A 16-MER RNA DUPLEX WITH NON-ADJACENT A(ANTI).G(SYN) MISMATCHES 分子名称: RNA (5'-R(*GP*CP*AP*GP*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3'), SODIUM ION 著者 Pan, B, Mitra, S.N, Sundaralingam, M. 登録日 1998-08-13 公開日 1999-01-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of an RNA 16-mer duplex R(GCAGAGUUAAAUCUGC)2 with nonadjacent G(syn).A+(anti) mispairs. Biochemistry, 38, 1999
6NKX	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with dGTP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
5NDH	The structure of the G. violaceus guanidine II riboswitch P2 stem-loop 分子名称: GUANIDINE, MAGNESIUM ION, RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3'), ... 著者 Huang, L, Wang, J, Lilley, D.M.J. 登録日 2017-03-08 公開日 2017-05-31 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The Structure of the Guanidine-II Riboswitch. Cell Chem Biol, 24, 2017
6PUI	Structure of human MAIT A-F7 TCR in complex with human MR1-4'OH-Butyl-5-OP-U 分子名称: 6-[(4-hydroxybutyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
2HB6	Structure of Caenorhabditis elegans leucine aminopeptidase (LAP1) 分子名称: GLYCEROL, Leucine aminopeptidase 1, SODIUM ION, ... 著者 Patskovsky, Y, Zhan, C, Wengerter, B.C, Ramagopal, U, Milstein, S, Vidal, M, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2006-06-13 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Caenorhabditis Elegans Leucine Aminopeptidase To be Published
6NKY	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.094 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
5LV2	Crystal structure of mouse CARM1 in complex with inhibitor LH1246 分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... 著者 Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. 登録日 2016-09-12 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos.Trans.R.Soc.Lond.B Biol.Sci., 373, 2018
6NKV	Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
6Q9S	HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[[6-chloranyl-3-[3-[(1~{S})-1-(2,4-dichlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]carbonylamino]-4-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]benzoic acid, Protein Mdm4, ... 著者 Kallen, J. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
4Y8F	Crystal structure of Triosephosphate Isomerase from Clostridium perfringens 分子名称: ACETATE ION, SODIUM ION, Triosephosphate Isomerase 著者 Romero-Romero, S, Rodriguez-Romero, A, Fernandez-Velasco, D.A. 登録日 2015-02-16 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
4Y90	Crystal structure of Triosephosphate Isomerase from Deinococcus radiodurans 分子名称: CALCIUM ION, GLYCEROL, SODIUM ION, ... 著者 Romero-Romero, S, Rodriguez-Romero, A, Fernadez-Velasco, D.A. 登録日 2015-02-16 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
6QDR	Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. 登録日 2019-01-02 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.615 Å) 主引用文献 Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
2HEE	CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY 分子名称: LYSOZYME, SODIUM ION 著者 Takano, K, Funahashi, J, Yamagata, Y, Fujii, S, Yutani, K. 登録日 1997-09-16 公開日 1998-01-14 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Contribution of water molecules in the interior of a protein to the conformational stability. J.Mol.Biol., 274, 1997
5NJF	E. coli Microcin-processing metalloprotease TldD/E (TldD H262A mutant) with pentapeptide bound 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALA-ALA-ALA-ALA-ALA, ... 著者 Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2017-03-28 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
6LP6	Crystal structure of human DHODH in complex with inhibitor 1214 分子名称: 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... 著者 Chen, Q, Yu, Y. 登録日 2020-01-09 公開日 2020-09-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.795 Å) 主引用文献 Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J.Med.Chem., 63, 2020
2PNK	CRYSTAL STRUCTURE OF AN URONATE ISOMERASE (BH0493) FROM BACILLUS HALODURANS C-125 AT 2.00 A RESOLUTION 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, BH0493 protein, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2007-04-24 公開日 2007-05-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of uncharacterized protein (NP_241359.1) from Bacillus halodurans at 2.00 A resolution To be published
5NJC	E. coli Microcin-processing metalloprotease TldD/E (TldD E263A mutant) with hexapeptide bound 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Metalloprotease PmbA, ... 著者 Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. 登録日 2017-03-28 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
4YB8	Ca. Korarchaeum cryptofilum dinucleotide forming Acetyl-coenzyme A synthetase 1 in complex with phosphate and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Weisse, R.H.-J, Scheidig, A.J. 登録日 2015-02-18 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer. Proc.Natl.Acad.Sci.USA, 113, 2016
4YD2	Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate 分子名称: CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... 著者 Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. 登録日 2015-02-20 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.471 Å) 主引用文献 Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015

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