PDB: 243911 件ウェブページステータス検索Chemie searchBIRD

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4CL7	Crystal structure of VEGFR-1 domain 2 in presence of Cobalt 分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 著者 Gaucher, J.-F, Reille-Seroussi, M, Gagey-Eilstein, N, Broussy, S, Coric, P, Seijo, B, Lascombe, M.-B, Gautier, B, Liu, W.-Q, Huguenot, F, Inguimbert, N, Bouaziz, S, Vidal, M, Broutin, I. 登録日 2014-01-13 公開日 2015-01-28 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Biophysical Studies of the Induced Dimerization of Human Vegf R Receptor 1 Binding Domain by Divalent Metals Competing with Vegf-A Plos One, 11, 2016
1IKW	Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz 分子名称: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, POL POLYPROTEIN 著者 Lindberg, J, Unge, T. 登録日 2001-05-07 公開日 2001-06-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur.J.Biochem., 269, 2002
3UF3	Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 分子名称: GLYCEROL, HIV-1 protease, YTTRIUM ION 著者 Agniswamy, J, Chen-Hsiang, S, Aniana, A, Sayer, J.M, Louis, J.M, Weber, I.T. 登録日 2011-10-31 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements. Biochemistry, 51, 2012
3I79	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) 分子名称: 1,2-ETHANEDIOL, Calmodulin-domain protein kinase 1 著者 Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) 登録日 2009-07-08 公開日 2009-08-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17, 2010
3UJJ	Crystal structure of anti-HIV-1 V3 Fab 4025 in complex with Con A peptide 分子名称: ACETATE ION, Fab region of the heavy chain of anti-HIV-1 V3 monoclonal antibody 4025, GLYCEROL, ... 著者 Kong, X.P, Sampson, J. 登録日 2011-11-07 公開日 2011-12-28 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure. Plos One, 6, 2011
3V81	Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine 分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... 著者 Das, K, Martinez, S.E, Arnold, E. 登録日 2011-12-22 公開日 2012-01-18 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.8503 Å) 主引用文献 HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
3VF7	Crystal Structure of HIV-1 Protease Mutant L76V with novel P1'-Ligands GRL-02031 分子名称: (3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(1S,2R)-1-benzyl-2-hydroxy-3-([(4-methoxyphenyl)sulfonyl]{[(2R)-5-oxopyrrolidin-2-yl]methyl}amino)propyl]carbamate, CHLORIDE ION, GLYCEROL, ... 著者 Yu, X.X, Wang, Y.F, Chang, Y.C.E, Weber, I.T. 登録日 2012-01-09 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. J.Med.Chem., 55, 2012
4DVW	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-167 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(3aS,6aS)-hexahydrocyclopenta[c]pyrrol-3a(1H)-ylmethyl]ethanediamide, ... 著者 Kwon, Y.D, Kwong, P.D. 登録日 2012-02-23 公開日 2013-02-27 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
3VZD	Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP 分子名称: 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Min, X, Walker, N.P, Wang, Z. 登録日 2012-10-11 公開日 2013-05-01 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. Structure, 21, 2013
2EGH	Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with a magnesium ion, NADPH and fosmidomycin 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MAGNESIUM ION, ... 著者 Yajima, S, Hara, K, Iino, D, Sasaki, Y, Kuzuyama, T, Seto, H. 登録日 2007-03-01 公開日 2007-06-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin Acta Crystallogr.,Sect.F, 63, 2007
3SFG	crystal structure of murine norovirus RNA dependent RNA polymerase in complex with 2thiouridine(2TU) 分子名称: 1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, GLYCEROL, MAGNESIUM ION, ... 著者 Kim, K.H, Alam, I. 登録日 2011-06-13 公開日 2012-05-09 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.209 Å) 主引用文献 Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin. Virology, 426, 2012
1RCX	NON-ACTIVATED SPINACH RUBISCO IN COMPLEX WITH ITS SUBSTRATE RIBULOSE-1,5-BISPHOSPHATE 分子名称: RIBULOSE BISPHOSPHATE CARBOXYLASE/OXYGENASE, RIBULOSE-1,5-DIPHOSPHATE 著者 Taylor, T.C, Andersson, I. 登録日 1996-12-06 公開日 1997-06-16 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The structure of the complex between rubisco and its natural substrate ribulose 1,5-bisphosphate. J.Mol.Biol., 265, 1997
3VFB	Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031 分子名称: (3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(1S,2R)-1-benzyl-2-hydroxy-3-([(4-methoxyphenyl)sulfonyl]{[(2R)-5-oxopyrrolidin-2-yl]methyl}amino)propyl]carbamate, CHLORIDE ION, GLYCEROL, ... 著者 Yu, X.X, Wang, Y.F, Chang, Y.C.E, Weber, I.T. 登録日 2012-01-09 公開日 2012-11-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. J.Med.Chem., 55, 2012
2E40	Crystal structure of intracellular family 1 beta-glucosidase BGL1A from the basidiomycete Phanerochaete chrysosporium in complex with gluconolactone 分子名称: Beta-glucosidase, D-glucono-1,5-lactone 著者 Nijikken, Y, Tsukada, T, Igarashi, K, Samejima, M, Fushinobu, S. 登録日 2006-12-01 公開日 2007-03-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of intracellular family 1 beta-glucosidase BGL1A from the basidiomycete Phanerochaete chrysosporium Febs Lett., 581, 2007
3A9C	Crystal structure of ribose-1,5-bisphosphate isomerase from Thermococcus kodakaraensis KOD1 in complex with ribulose-1,5-bisphosphate 分子名称: DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, RIBULOSE-1,5-DIPHOSPHATE, ... 著者 Nakamura, A, Fujihashi, M, Nishiba, Y, Yoshida, S, Yano, A, Atomi, H, Imanaka, T, Miki, K. 登録日 2009-10-22 公開日 2010-11-03 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1 J.Biol.Chem., 287, 2012
3S43	HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug amprenavir 分子名称: GLYCEROL, IODIDE ION, Protease, ... 著者 Wang, Y.-F, Tie, Y.-F, Weber, I.T. 登録日 2011-05-18 公開日 2012-03-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors. Protein Sci., 21, 2012
4KKO	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor 分子名称: 4-({4-methoxy-6-[2-(morpholin-4-yl)ethoxy]-1,3,5-triazin-2-yl}amino)-2-(3-methylbutoxy)benzonitrile, HIV-1 reverse transcriptase, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2013-05-06 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Extension into the entrance channel of HIV-1 reverse transcriptase-Crystallography and enhanced solubility. Bioorg.Med.Chem.Lett., 23, 2013
3B38	Structure of A104V DJ-1 分子名称: 1,2-ETHANEDIOL, Protein DJ-1 著者 Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. 登録日 2007-10-19 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
3T19	Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05 分子名称: 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine, Reverse Transcriptase 著者 Yan, Y, Reid, J. 登録日 2011-07-21 公開日 2011-10-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. J.Med.Chem., 54, 2011
3B36	Structure of M26L DJ-1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1 著者 Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. 登録日 2007-10-19 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1. Biochemistry, 47, 2008
2QCI	HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ... 著者 Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T. 登録日 2007-06-19 公開日 2008-04-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50, 2007
2QD8	HIV-1 Protease Mutant I84V with potent Antiviral inhibitor GRL-98065 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ... 著者 Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T. 登録日 2007-06-20 公開日 2008-04-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50, 2007
4DJO	Crystal Structure of wild-type HIV-1 Protease in Complex with MKP56 分子名称: 2-[(dichloroacetyl)amino]ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, ACETATE ION, GLYCEROL, ... 著者 Schiffer, C.A, Nalam, M.N.L. 登録日 2012-02-02 公開日 2012-08-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J.Med.Chem., 55, 2012
4DVS	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-557 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide, ... 著者 Kwon, Y.D, Kwong, P.D. 登録日 2012-02-23 公開日 2013-02-27 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
2R8T	Crystal structure of the fructose 1,6-bisphosphatase GlpX from E.coli in the complex with fructose 1,6-bisphosphate 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase class II glpX, UNKNOWN ATOM OR ION 著者 Lunin, V.V, Skarina, T, Brown, G, Yakunin, A, Edwards, A.M, Savchenko, A. 登録日 2007-09-11 公開日 2008-08-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the fructose 1,6-bisphosphatase GlpX from E.coli in the complex with fructose 1,6-bisphosphate To be Published

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