8V3B
 
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8V38
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8V34
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8V33
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8V31
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8V30
 | | Smooth Muscle Gamma Actin (ACTG2) Filament Mutant R40C | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | | 登録日 | 2023-11-25 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy.
Sci Adv, 10, 2024
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8V2Z
 | | Cryo-EM Structure of Smooth Muscle Gamma Actin (ACTG2) Mutant R257C | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | | 登録日 | 2023-11-25 | | 公開日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Smooth Muscle Gamma Actin (ACTG2) Filament Mutant R257C
To Be Published
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8V2Y
 | | Room temperature X-ray Crystal Structure of FMN-bound long-chain flavodoxin from Rhodopseudomonas palustris | | 分子名称: | FLAVIN MONONUCLEOTIDE, Flavodoxin | | 著者 | Ansari, A, Khan, S.A, Miller, A.F. | | 登録日 | 2023-11-24 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Structure, dynamics, and redox reactivity of an all-purpose flavodoxin.
J.Biol.Chem., 300, 2024
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8V2T
 | | Phosphoheptose isomerase GMHA from Burkholderia pseudomallei bound to inhibitor Mut148591 | | 分子名称: | 1,5,6-trideoxy-6,6-difluoro-1-(N-hydroxyformamido)-6-phosphono-D-ribo-hexitol, CHLORIDE ION, Phosphoheptose isomerase, ... | | 著者 | Junop, M.S, Brown, C, Szabla, R. | | 登録日 | 2023-11-23 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.402 Å) | | 主引用文献 | Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria.
J.Med.Chem., 67, 2024
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8V2O
 | | Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | | 登録日 | 2023-11-23 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | | 主引用文献 | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy.
Sci Adv, 10, 2024
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8V2N
 | | Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD | | 分子名称: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLN-PRO-LYS-FDL, NAD-dependent protein deacetylase sirtuin-3, ... | | 著者 | Chakrabarti, R, Ghosh, A, Guan, X, Upadhyay, A, Dumpati, R.K, Munshi, S, Roy, S, Chall, S, Rahnamoun, A, Reverdy, C, Errasti, G, Delacroix, T. | | 登録日 | 2023-11-23 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion
biorxiv, 2023
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8V2L
 | | Crystal structure of IRAK4 kinase domain with compound 8 | | 分子名称: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-22 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 2024
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8V2K
 | | Proteus vulgaris tryptophan indole-lyase complexed with L-alanine | | 分子名称: | (2E)-2-{[(Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4(1H)-YLIDENE}METHYL]IMINO}PROPANOIC ACID, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, DIMETHYL SULFOXIDE, ... | | 著者 | Phillips, R.S. | | 登録日 | 2023-11-22 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Proteus vulgaris tryptophan indole-lyase complexed with L-alanine
To Be Published
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8V2F
 | | Crystal structure of IRAK4 kinase domain with compound 9 | | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-22 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 2024
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8V2E
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8V2D
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8V24
 | | LapB cytoplasmic domain in complex with LpxC | | 分子名称: | ACETATE ION, Lipopolysaccharide assembly protein B, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | | 著者 | Mi, W, Shu, S. | | 登録日 | 2023-11-21 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8V1P
 | | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092 | | 分子名称: | Glucose-induced degradation protein 4 homolog, N,N~2~-bis[(4-methoxyphenyl)methyl]glycinamide | | 著者 | Dong, C, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2023-11-21 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092
To be published
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8V1O
 | | Crystal structure of IRAK4 kinase domain with compound 4 | | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | 登録日 | 2023-11-21 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 2024
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8V1L
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8V1K
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8V1J
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8V1I
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8V1H
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8V1F
 | | TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Fraser, B.J, Dong, A, Kutera, M, Seitova, A, Li, Y, Hutchinson, A, Edwards, A, Benard, F, Halabelian, L, Arrowsmith, C, Structural Genomics Consortium (SGC) | | 登録日 | 2023-11-20 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol
To Be Published
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