PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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3LFG	Crystal structure of HPr-C-His from Thermoanaerobacter tengcongensis 分子名称: Phosphotransferase system, HPr-related proteins 著者 Fu, T.M, Su, X.D. 登録日 2010-01-17 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Dimerization of HPr by reversible domain swapping To be Published
5G1X	Crystal structure of Aurora-A kinase in complex with N-Myc 分子名称: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ... 著者 Richards, M.W, Burgess, S.G, Bayliss, R. 登録日 2016-03-31 公開日 2016-11-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors Proc.Natl.Acad.Sci.USA, 113, 2016
5G26	Unveiling the Mechanism Behind the in-meso Crystallization of Membrane Proteins 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, INTIMIN 著者 Zabara, A, Newman, J, Peat, T.S. 登録日 2016-04-07 公開日 2017-02-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 The Nanoscience Behind the Art of in-Meso Crystallization of Membrane Proteins. Nanoscale, 9, 2017
5G5W	Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators 分子名称: 1,2-ETHANEDIOL, 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-yl]acetamide, GLUCOCORTICOID RECEPTOR, ... 著者 Hemmerling, M, Edman, K, Lepisto, M, Eriksson, A, Ivanova, S, Dahmen, J, Rehwinkel, H, Berger, M, Hendrickx, R, Dearman, M, Jellesmark-Jensen, T, Wissler, L, Hansson, T. 登録日 2016-06-08 公開日 2017-02-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Indazole Ethers as Novel, Potent, Non-Steroidal Glucocorticoid Receptor Modulators. Bioorg.Med.Chem.Lett., 26, 2017
3LIQ	Crystal Structure of HTLV protease complexed with the inhibitor, KNI-10673 分子名称: (4R)-3-[(2S,3S)-3-[[(2S)-2-[[(2S)-2-azanyl-2-phenyl-ethanoyl]amino]-3,3-dimethyl-butanoyl]amino]-2-hydroxy-4-phenyl-but anoyl]-5,5-dimethyl-N-(2-methylpropyl)-1,3-thiazolidine-4-carboxamide, Protease 著者 Satoh, T, Li, M, Nguyen, J, Kiso, Y, Wlodawer, A, Gustchina, A. 登録日 2010-01-25 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease. J.Mol.Biol., 401, 2010
3LFS	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor 分子名称: Cell division protein kinase 2, N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide 著者 Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. 登録日 2010-01-18 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
5G2I	S. enterica HisA mutant Dup13-15(VVR) 分子名称: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, PHOSPHATE ION, SODIUM ION 著者 Guo, X, Soderholm, A, Newton, M, Nasvall, J, Duarte, F, Andersson, D, Patrick, W, Selmer, M. 登録日 2016-04-08 公開日 2017-04-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3LJ3	PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor 分子名称: (2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Bard, J, Svenson, K. 登録日 2010-01-25 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg.Med.Chem.Lett., 20, 2010
5G2Z	Crystallographic structure of mutant W31A of thioredoxin from Litopenaeus vannamei 分子名称: THIOREDOXIN 著者 Campos-Acevedo, A.A, Rudino-Pinera, E. 登録日 2016-04-18 公開日 2017-03-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Is dimerization a common feature in thioredoxins? The case of thioredoxin from Litopenaeus vannamei. Acta Crystallogr D Struct Biol, 73, 2017
3LGB	Crystal Structure of the Fe-S Domain of the yeast DNA primase 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA primase large subunit, GLYCEROL, ... 著者 Sauguet, L, Pellegrini, L. 登録日 2010-01-20 公開日 2010-04-21 最終更新日 2011-10-05 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase PLOS ONE, 5, 2010
5G6K	Structure of Bacillus subtilis Nitric Oxide Synthase I218V in complex with 7-((3-(2-(Methylamino)ethyl)phenoxy)methyl)quinolin-2- amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[3-[2-(methylamino)ethyl]phenoxy]methyl]quinolin-2-amine, CHLORIDE ION, ... 著者 Holden, J.K, Lewis, M.C, Poulos, T.L. 登録日 2016-06-18 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry, 55, 2016
5G2R	Crystal structure of the Mo-insertase domain Cnx1E from Arabidopsis thaliana 分子名称: GLYCEROL, MAGNESIUM ION, MOLYBDOPTERIN BIOSYNTHESIS PROTEIN CNX1, ... 著者 Krausze, J, Saha, S, Probst, C, Kruse, T, Heinz, D.W, Mendel, R.R. 登録日 2016-04-13 公開日 2017-02-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Dimerization of the Plant Molybdenum Insertase Cnx1E is Required for Synthesis of the Molybdenum Cofactor. Biochem.J., 474, 2017
3LGO	Structure of Gse1p, member of the GSE/EGO complex 分子名称: Protein SLM4 著者 Kogan, K, Fass, D. 登録日 2010-01-21 公開日 2010-08-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. J.Mol.Biol., 402, 2010
5G6O	Structure of Bacillus subtilis Nitric Oxide Synthase in complex with two molecules of 7-((4-(Dimethylamino)methyl)phenoxy)methyl)quinolin- 2- amine 分子名称: 7-[[4-[(dimethylamino)methyl]phenoxy]methyl]quinolin-2-amine, CHLORIDE ION, GLYCEROL, ... 著者 Holden, J.K, Poulos, T.L. 登録日 2016-06-18 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.719 Å) 主引用文献 Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry, 55, 2016
3LJO	Bovine trypsin in complex with UB-THR 11 分子名称: (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... 著者 Wegscheid-Gerlach, C, Heine, A, Klebe, G. 登録日 2010-01-26 公開日 2010-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties. J.Mol.Biol., 405, 2011
5G35	Structure of Rad14 in complex with acetylaminopyren-C8-guanine containing DNA 分子名称: 5'-D(*GP*CP*TP*CP*TP*AP*8PYP*TP*CP*AP*TP*CP*AP*CP)-3', 5'-D(*GP*TP*GP*AP*TP*GP*AP*CP*GP*TP*AP*GP*AP*GP)-3', RAD14, ... 著者 Simon, N, Ebert, C, Schneider, S. 登録日 2016-04-18 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Bulky Adduct DNA Lesion Recognition by the Nucleotide Excision Repair Protein Rad14. Chemistry, 22, 2016
6OQ1	Crystal Structure of Branched K11/K48-Linked Tri-Ubiquitin 分子名称: Ubiquitin 著者 Boughton, A.J, Fushman, D. 登録日 2019-04-25 公開日 2019-10-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1. Structure, 28, 2020
5G3J	Discovery of New Selective Glucocorticoid Receptor Agonist Leads 分子名称: 1,2-ETHANEDIOL, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, 5-[[(1S,2R,4R)-4-ethyl-6,7-bis(fluoranyl)-2,5-bis(oxidanyl)-2-(trifluoromethyl)-3,4-dihydro-1H-naphthalen-1-yl]amino]-1H-quinolin-2-one, ... 著者 Berger, M, Edman, K, Wissler, L, Neuhaus, R, Rehwinkel, H, Schacke, H, Jaroch, S. 登録日 2016-04-27 公開日 2017-02-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of New Selective Glucocorticoid Receptor Agonist Leads. Bioorg.Med.Chem.Lett., 27, 2017
3LH4	Crystal Structure of Sialostatin L2 分子名称: GLYCEROL, SULFATE ION, Secreted cystatin 著者 Andersen, J.F, Kotsyfakis, M, Salat, J, Horka, H. 登録日 2010-01-21 公開日 2010-09-29 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model. Mol.Microbiol., 77, 2010
5G6N	Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-((4-(Dimethylamino)methyl)phenoxy)methyl)quinolin-2- amine 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[4-[(dimethylamino)methyl]phenoxy]methyl]quinolin-2-amine, ... 著者 Holden, J.K, Poulos, T.L. 登録日 2016-06-18 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry, 55, 2016
5G3Z	Crystal structure of adenylate kinase ancestor 3 with Zn, Mg and Ap5A bound 分子名称: ADENYLATE KINSE, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... 著者 Nguyen, V, Kutter, S, English, J, Kern, D. 登録日 2016-05-03 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
3LHB	THE 2.7 ANGSTROM CRYSTAL STRUCTURE OF DEOXYGENATED HEMOGLOBIN FROM THE SEA LAMPREY (PETROMYZON MARINUS) 分子名称: PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE 著者 Heaslet, H.A, Royer Jr, W.E. 登録日 1999-01-12 公開日 1999-01-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The 2.7 A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect. Structure Fold.Des., 7, 1999
5G24	Type IV-like pilin TTHA1219 from Thermus thermophilus 分子名称: TYPE-IV LIKE PILIN TTHA1219 著者 Karuppiah, V, Derrick, J.P. 登録日 2016-04-06 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of Type Iv Pilins from Thermus Thermophilus Demonstrate Similarities with Type II Secretion System Pseudopilins J.Struct.Biol., 196, 2016
5G3P	Bacillus cereus formamidase (BceAmiF) acetylated at the active site. 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Gavira, J.A, Conejero-Muriel, M, Martinez-Rodriguez, S. 登録日 2016-04-29 公開日 2017-04-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 A novel cysteine carbamoyl-switch is responsible for the inhibition of formamidase, a nitrilase superfamily member. Arch.Biochem.Biophys., 662, 2019
3LIH	Crystal structure of fructosyltransferase (D191A) from A. japonicus in complex with raffinose 分子名称: Fructosyltransferase, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose-(1-2)-beta-D-fructofuranose 著者 Chuankhayan, P, Chen, C.J, Chiang, C.M. 登録日 2010-01-24 公開日 2010-05-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of Aspergillus japonicus fructosyltransferase complex with donor/acceptor substrates reveal complete subsites in the active site for catalysis J.Biol.Chem., 285, 2010

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