PDB: 3581 件ウェブページステータス検索Chemie searchBIRD

---

5EI3	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-29 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5GAG	RNC in complex with SRP-SR in the closed state 分子名称: 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-26 公開日 2016-01-27 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
5FCI	Structure of the vacant uL3 W255C mutant 80S yeast ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M. 登録日 2015-12-15 公開日 2016-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. J.Mol.Biol., 428, 2016
5GAF	RNC in complex with SRP 分子名称: 1A9L SS, 23S ribosomal RNA, 50S ribosomal protein L10, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-25 公開日 2016-02-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon Nat Commun, 7, 2016
5DOX	Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N. 登録日 2015-09-11 公開日 2015-12-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
5EKV	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-11-04 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.61 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5EL5	Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. 登録日 2015-11-04 公開日 2016-01-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
5H2F	Crystal structure of the PsbM-deletion mutant of photosystem II 分子名称: (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... 著者 Uto, S, Kawakami, K, Umena, Y, Iwai, M, Ikeuchi, M, Shen, J.R, Kamiya, N. 登録日 2016-10-15 公開日 2017-03-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mutual relationships between structural and functional changes in a PsbM-deletion mutant of photosystem II. Faraday Discuss., 198, 2017
5GAH	RNC in complex with SRP with detached NG domain 分子名称: 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-26 公開日 2016-01-27 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
5EL6	Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. 登録日 2015-11-04 公開日 2016-01-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
5EHC	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-10-28 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
5E7K	Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. 登録日 2015-10-12 公開日 2016-01-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
5GAD	RNC-SRP-SR complex early state 分子名称: 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-24 公開日 2016-01-27 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
8BN3	Yeast 80S, ES7s delta, eIF5A, Stm1 containing 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... 著者 Dimitrova-Paternoga, L, Paternoga, H, Wilson, D.N. 登録日 2022-11-12 公開日 2024-01-10 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Evolving precision: rRNA expansion segment 7S modulates translation velocity and accuracy in eukaryal ribosomes. Nucleic Acids Res., 52, 2024
7A4H	Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-2 (180-mer) 分子名称: Antitermination protein N,6,7-dimethyl-8-ribityllumazine synthase,6,7-dimethyl-8-ribityllumazine synthase 著者 Tetter, S, Hilvert, D. 登録日 2020-08-19 公開日 2021-06-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein. Science, 372, 2021
7A4G	Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-1 (180-mer) 分子名称: Antitermination protein N,6,7-dimethyl-8-ribityllumazine synthase,6,7-dimethyl-8-ribityllumazine synthase 著者 Tetter, S, Hilvert, D. 登録日 2020-08-19 公開日 2021-06-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein. Science, 372, 2021
8CRX	Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound 分子名称: 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Lomakin, I.B, Devarkar, S.C, Bunick, C.G. 登録日 2022-05-12 公開日 2023-03-22 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res., 51, 2023
8CAM	Evernimicin bound to the 50S subunit 分子名称: 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... 著者 Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. 登録日 2023-01-24 公開日 2023-07-26 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (1.86 Å) 主引用文献 Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
7AC7	Structure of accomodated trans-translation complex on E. Coli stalled ribosome. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. 登録日 2020-09-10 公開日 2021-08-18 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
7A0S	50S Deinococcus radiodurans ribosome bounded with mycinamicin I 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. 登録日 2020-08-10 公開日 2021-08-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res., 49, 2021
7A0R	50S Deinococcus radiodurans ribosome bounded with mycinamicin I 分子名称: 50S ribosomal protein L13, 50S ribosomal protein L14, 50S ribosomal protein L15, ... 著者 Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. 登録日 2020-08-10 公開日 2021-08-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res., 49, 2021
8CKB	Asymmetric reconstruction of the crAss001 virion 分子名称: Auxiliary capsid protein gp36, Cargo protein 1 gp45, Head fiber dimer protein gp29, ... 著者 Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. 登録日 2023-02-16 公開日 2023-11-22 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.39 Å) 主引用文献 Structural atlas of the most abundant human gut virus Nature
8C3A	Crystal structure of ailanthone bound to the Candida albicans 80S ribosome 分子名称: 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... 著者 Kolosova, O, Zgadzay, Y, Yusupov, M. 登録日 2022-12-23 公開日 2024-01-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 New crystal system to promote screening for new eukaryotic inhibitors To Be Published
7B5K	E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. 分子名称: 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... 著者 Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. 登録日 2020-12-03 公開日 2021-05-26 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities Nat Commun, 2021
8CVL	Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. 登録日 2022-05-18 公開日 2022-10-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes. Nat.Chem., 15, 2023

<8687888990919293949596979899100101>