PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

---

7Q4N	transcription factor CDX2 bound to hydroxymethylated DNA 分子名称: DNA (18-MER), Homeobox protein CDX-2 著者 Morgunova, E, Yin, Y, Popov, A, Taipale, J. 登録日 2021-11-01 公開日 2022-11-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 transcription factor CDX2 bound to hydroxymethylated DNA To Be Published
5JZN	Crystal structure of DCLK1-KD in complex with NVP-TAE684 分子名称: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, SULFATE ION, Serine/threonine-protein kinase DCLK1 著者 Patel, O, Lucet, I. 登録日 2016-05-17 公開日 2016-08-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure, 24, 2016
5K5L	Homo sapiens CCCTC-binding factor (CTCF) ZnF6-8 and H19 sequence DNA complex structure 分子名称: DNA (5'-D(*GP*TP*TP*GP*CP*CP*GP*CP*GP*TP*G)-3'), DNA (5'-D(P*AP*CP*GP*CP*GP*GP*CP*AP*AP*C)-3'), Transcriptional repressor CTCF, ... 著者 Hashimoto, H, Cheng, X. 登録日 2016-05-23 公開日 2017-05-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.125 Å) 主引用文献 Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
8C6N	Human protein kinase CK2 alpha in complex with CK2-TN03 分子名称: (2~{Z},5~{Z})-5-[(4-methoxy-3-oxidanyl-phenyl)methylidene]-2-phenylimino-1,3-thiazolidin-4-one, Casein kinase II subunit alpha, SULFATE ION 著者 Dalle Vedove, A, Cazzanelli, G, Lolli, G. 登録日 2023-01-12 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma to be published
5K7K	Design and Optimization of Biaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7: Discovery of Clinical Candidate PF-05089771 分子名称: 4-[4-chloranyl-2-(1~{H}-pyrazol-4-yl)phenoxy]-3-cyano-~{N}-(1,3-thiazol-2-yl)benzenesulfonamide, Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE 著者 Swain, N, Chrencik, J. 登録日 2016-05-26 公開日 2017-06-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7. J. Med. Chem., 60, 2017
8C6M	Human protein kinase CK2 alpha in complex with CK2-TN02 分子名称: (5~{Z})-5-[(3-methoxy-4-oxidanyl-phenyl)methylidene]-1,3-thiazolidine-2,4-dione, Casein kinase II subunit alpha, SULFATE ION 著者 Dalle Vedove, A, Cazzanelli, G, Lolli, G. 登録日 2023-01-12 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma to be published
5K1L	Dehaloperoxidase B from Amphitrite ornata: benzimidazole complex 分子名称: BENZIMIDAZOLE, Dehaloperoxidase B, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Moreno Chicano, T, Hough, M.A. 登録日 2016-05-18 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.08 Å) 主引用文献 Dehaloperoxidase B from Amphitrite ornata: benzimidazole complex to be published
5K7R	MicroED structure of trypsin at 1.7 A resolution 分子名称: CALCIUM ION, Cationic trypsin 著者 de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. 登録日 2016-05-26 公開日 2017-04-05 最終更新日 2018-08-22 実験手法 ELECTRON CRYSTALLOGRAPHY (1.7 Å) 主引用文献 Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
5GGE	Fatty Acid-Binding Protein in Brain Tissue of Drosophila melanogaster 分子名称: CITRIC ACID, Fatty acid bindin protein, isoform B 著者 Cheng, Y.-Y, Huang, Y.-F, Lin, H.-H, Chang, W.W, Lyu, P.-C. 登録日 2016-06-15 公開日 2017-06-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.861 Å) 主引用文献 The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport. Biochim Biophys Acta Mol Cell Biol Lipids, 1864, 2019
8C6L	Human protein kinase CK2 alpha in complex with CK2-TN01 分子名称: 1,2-ETHANEDIOL, 5-azanyl-3-[(~{Z})-1-cyano-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]-3~{H}-pyrazole-4-carbonitrile, Casein kinase II subunit alpha, ... 著者 Dalle Vedove, A, Cazzanelli, G, Lolli, G. 登録日 2023-01-12 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma to be published
8PTE	Polyoxidovanadate interaction with proteins: crystal structure of lysozyme bound to octadecavanadate ion (structure B) 分子名称: Lysozyme C, NITRATE ION, Polyoxidovanadate complex, ... 著者 Tito, G, Ferraro, G, Merlino, A. 登録日 2023-07-14 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 Stabilization and Binding of [V 4 O 12 ] 4- and Unprecedented [V 20 O 54 (NO 3 )] n- to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V IV O(acetylacetonato) 2. Angew.Chem.Int.Ed.Engl., 62, 2023
5GJJ	Glutathionylated hHsp70 SBD 分子名称: Heat shock 70 kDa protein 1A 著者 Gong, W.B, Yang, J, Zhang, H, Perrett, S. 登録日 2016-06-30 公開日 2017-07-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
5KBK	Candida Albicans Superoxide Dismutase 5 (SOD5), E110A Mutant 分子名称: COPPER (I) ION, Cell surface Cu-only superoxide dismutase 5, SULFATE ION 著者 Galaleldeen, A, Peterson, R.L, Villarreal, J, Taylor, A.B, Hart, P.J. 登録日 2016-06-03 公開日 2016-08-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.411 Å) 主引用文献 The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J.Biol.Chem., 291, 2016
8CPR	G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer 分子名称: GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Moche, M, Jungholm, O, Strandback, E, Ampah-Korsah, H, Nyman, T, Orwar, O. 登録日 2023-03-03 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A G13D open-state-selective anti-KRAS antibody shows in vivo anti-cancer activity To Be Published
5JR8	Disposal of Iron by a Mutant form of Siderocalin NGAL 分子名称: GLYCEROL, Neutrophil gelatinase-associated lipocalin, PHOSPHATE ION 著者 Rupert, P.B, Strong, R.K, Barasch, J, Hollman, M, Deng, R, Hod, E.A, Abergel, R, Allred, B, Xu, K, Darrah, S, Tekabe, Y, Perlstein, A, Bruck, E, Stauber, J, Corbin, K, Buchen, C, Slavkovich, V, Graziano, J, Spitalnik, S, Qiu, A. 登録日 2016-05-05 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Disposal of iron by a mutant form of lipocalin 2. Nat Commun, 7, 2016
7PE3	Pseudo-atomic model of the tetrahedral 24mer of Hsp17 from Caenorhabditis elegans 分子名称: SHSP domain-containing protein 著者 Rossa, B, Weinkauf, S, Buchner, J. 登録日 2021-08-09 公開日 2022-12-14 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (6.49 Å) 主引用文献 The permanently chaperone-active small heat shock protein Hsp17 from Caenorhabditis elegans exhibits topological separation of its N-terminal regions. J.Biol.Chem., 299, 2022
7Q33	Solution structure of RBM39 RRM2 bound to 5'-AGCUUUG-3 分子名称: RNA (5'-R(*AP*GP*CP*UP*UP*UP*G)-3'), RNA-binding protein 39 著者 Campagne, S, Allain, F.H. 登録日 2021-10-26 公開日 2023-02-08 最終更新日 2023-09-20 実験手法 SOLUTION NMR 主引用文献 Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39. Nat Commun, 14, 2023
5GWE	cytochrome P450 CREJ 分子名称: (4-methylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Dong, S, liu, X, Wang, X, Feng, Y. 登録日 2016-09-11 公開日 2017-07-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7PVU	Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1 分子名称: Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide 著者 Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. 登録日 2021-10-05 公開日 2023-05-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.154 Å) 主引用文献 Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
5K5H	Homo sapiens CCCTC-binding factor (CTCF) ZnF4-7 and DNA complex structure 分子名称: DNA (5'-D(*CP*AP*GP*CP*AP*GP*GP*GP*GP*GP*CP*GP*C)-3'), DNA (5'-D(*CP*GP*CP*CP*CP*CP*CP*TP*GP*CP*TP*GP*G)-3'), Transcriptional repressor CTCF, ... 著者 Hashimoto, H, Cheng, X. 登録日 2016-05-23 公開日 2017-05-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.108 Å) 主引用文献 Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
8CW0	20us Temperature-Jump (Light) XFEL structure of Lysozyme 分子名称: ACETATE ION, CHLORIDE ION, Lysozyme C, ... 著者 Wolff, A.M, Thompson, M.C, Fraser, J.S, Nango, E. 登録日 2022-05-18 公開日 2022-06-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. Nat.Chem., 15, 2023
8CWH	200us Temperature-Jump (Dark2) XFEL structure of Lysozyme Bound to N,N'-diacetylchitobiose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... 著者 Wolff, A.M, Thompson, M.C, Fraser, J.S, Nango, E. 登録日 2022-05-19 公開日 2022-06-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. Nat.Chem., 15, 2023
7PTI	STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS 分子名称: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION 著者 Eigenbrot, C, Randal, M, Kossiakoff, A.A. 登録日 1990-03-08 公開日 1991-04-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Eng., 3, 1990
7QNP	Designed Armadillo repeat protein N(A4)M4C(AII) co-crystallized with hen egg white lysozyme 分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Designed Armadillo Repeat Protein N(A4)M4C(AII), ... 著者 Michel, E, Mittl, P.R.E, Plueckthun, A. 登録日 2021-12-21 公開日 2022-06-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62, 2023
8CW7	200us Temperature-Jump (Dark2) XFEL structure of Lysozyme 分子名称: ACETATE ION, CHLORIDE ION, Lysozyme C, ... 著者 Wolff, A.M, Thompson, M.C, Fraser, J.S, Nango, E. 登録日 2022-05-18 公開日 2022-06-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. Nat.Chem., 15, 2023

<8687888990919293949596979899100101>