8CPR

G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer

Summary for 8CPR

• Entry DOI: 10.2210/pdb8cpr/pdb
• Descriptor: GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, ... (4 entities in total)
• Functional Keywords: kras, colorectal cancer, ras signalling, cancer stem cells, ras-driven metastasis, kras structure, kras mutations, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19929.10

Authors

Moche, M.,Jungholm, O.,Strandback, E.,Ampah-Korsah, H.,Nyman, T.,Orwar, O. (deposition date: 2023-03-03, release date: 2024-06-12)

• Primary citation: Moche, M.,Jungholm, O.,Strandback, E.,Nyman, T.,Orwar, O.,Ampah-Korsah, H.; A G13D open-state-selective anti-KRAS antibody shows in vivo anti-cancer activity; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)