8COO
 
 | | Solution structure of Zipcode binding protein 1 (ZBP1) KH3(DD)KH4 domains in complex with N6-Methyladenosine containing RNA | | 分子名称: | Insulin-like growth factor 2 mRNA-binding protein 1, RNA_(5'-R(*(UP*CP*GP*GP*(6MZ)P*CP*U)-3') | | 著者 | Nicastro, G, Abis, G, Taylor, I.A, Ramos, A. | | 登録日 | 2023-02-28 | | 公開日 | 2024-02-07 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers.
Nucleic Acids Res., 51, 2023
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5GKB
 | | Crystal Structure of Fatty Acid-Binding Protein in Brain Tissue of Drosophila melanogaster without citrate inside | | 分子名称: | Fatty acid bindin protein, isoform B | | 著者 | Cheng, Y.-Y, Huang, Y.-F, Lin, H.-H, Chang, W.W, Lyu, P.-C. | | 登録日 | 2016-07-04 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport.
Biochim Biophys Acta Mol Cell Biol Lipids, 1864, 2019
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8Q9S
 | | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR SGC-CK2-1 | | 分子名称: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha', ~{N}-[5-[[3-cyano-7-(cyclopropylamino)-3~{H}-pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]propanamide | | 著者 | Werner, C, Lindenblatt, D, Niefind, K. | | 登録日 | 2023-08-21 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.352 Å) | | 主引用文献 | Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool
Kinases Phosphatases, 2023
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5K4I
 | | Crystal Structure of ERK2 in complex with compound 22 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Mitogen-activated protein kinase 1 | | 著者 | Yin, J, Wang, W. | | 登録日 | 2016-05-20 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J.Med.Chem., 59, 2016
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8QBU
 | | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR CX-4945 AND THE ALPHA-D-POCKET LIGAND 3,4-DICHLORO PHENETHYLAMINE (DPA) | | 分子名称: | 1,2-ETHANEDIOL, 2-(3,4-dichlorophenyl)ethanamine, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, ... | | 著者 | Werner, C, Niefind, K. | | 登録日 | 2023-08-25 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool
Kinases Phosphatases, 2023
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8QF1
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7Q4A
 | | Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib | | 分子名称: | Altiratinib, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Swale, C, Bellini, V, Bowler, M. | | 登録日 | 2021-10-29 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase.
Sci Transl Med, 14, 2022
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8QBC
 | | Reactive amide intermediate in sperm whale myoglobin mutant H64V V68A | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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8Q6M
 | | Human SOD1 low dose data collecton | | 分子名称: | ACETATE ION, COPPER (II) ION, SULFATE ION, ... | | 著者 | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | | 登録日 | 2023-08-14 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
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5GWB
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5JPV
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8QBA
 | | Sperm whale myoblogin mutant H64V V68A in complex with glycine ethyl ester | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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5JQ2
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8CKM
 | | Semaphorin-5A TSR 3-4 domains | | 分子名称: | Semaphorin-5A | | 著者 | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Semaphorin-5A TSR 3-4 domains
To Be Published
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8CKG
 | | Semaphorin-5A TSR 3-4 domains in complex with sulfate | | 分子名称: | SULFATE ION, Semaphorin-5A, alpha-D-mannopyranose | | 著者 | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.714 Å) | | 主引用文献 | Semaphorin-5A TSR 3-4 domains in complex with sulfate
To Be Published
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8CKK
 | | Semaphorin-5A TSR 3-4 domains in complex with nitrate | | 分子名称: | NITRATE ION, Semaphorin-5A, alpha-D-mannopyranose | | 著者 | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Semaphorin-5A TSR 3-4 domains in complex with nitrate
To Be Published
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8CKL
 | | Semaphorin-5A TSR 3-4 domains in complex with sucrose octasulfate (SOS) | | 分子名称: | 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-2)-1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose, Semaphorin-5A, alpha-D-mannopyranose | | 著者 | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Semaphorin-5A TSR 3-4 domains in complex with sucrose octasulfate (SOS)
To Be Published
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8CKN
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7PZO
 | | mite allergen Der p 3 from Dermatophagoides pteronyssinus | | 分子名称: | SULFATE ION, mite allergen Der p 3 | | 著者 | Timofeev, V.I, Shevtsov, M.B, Abramchik, Y.A, Mikheeva, O.O, Kostromina, M.A, Lykoshin, D.D, Zayats, E.A, Zavriev, S.K, Esipov, R.S, Kuranova, I.P. | | 登録日 | 2021-10-13 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural plasticity and thermal stability of the histone-like protein from Spiroplasma melliferum are due to phenylalanine insertions into the conservative scaffold.
J.Biomol.Struct.Dyn., 36, 2018
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8COG
 | | Human arginylated beta-actin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | 著者 | Pinto, C.S, Bakker, S.E, Suchenko, A, Hussain, H, Hatano, T, Sampath, K, Chinthalapudi, K, Mishima, M, Balasubramanian, M. | | 登録日 | 2023-02-28 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.499 Å) | | 主引用文献 | Structure and physiological investigation of human arginylated beta-actin
To Be Published
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5G6U
 | | Crystal structure of langerin carbohydrate recognition domain with GlcNS6S | | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Porkolab, V, Chabrol, E, Varga, N, Ordanini, S, Sutkeviciute, I, Thepaut, M, Bernardi, A, Fieschi, F. | | 登録日 | 2016-07-21 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.844 Å) | | 主引用文献 | Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition.
ACS Chem. Biol., 13, 2018
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7Q3O
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5JYI
 | | Trypsin bound with succinic acid at 1.9A | | 分子名称: | CALCIUM ION, Cationic trypsin, SODIUM ION, ... | | 著者 | Manohar, R, Kutumbarao, N.H.V, KarthiK, L, Malathy, P, Velmurugan, D, Gunasekaran, K. | | 登録日 | 2016-05-14 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.914 Å) | | 主引用文献 | Trypsin bound with succinic acid at 1.9A
To Be Published
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7PVZ
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5JYM
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