8FLC
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6QUL
| Structure of a bacterial 50S ribosomal subunit in complex with the novel quinoxolidinone antibiotic cadazolid | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Scaiola, A, Leibundgut, M, Boehringer, D, Ritz, D. | 登録日 | 2019-02-27 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic. Sci Rep, 9, 2019
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3FXR
| Crystal structure of TsaR in complex with sulfate | 分子名称: | ASCORBIC ACID, GLYCEROL, LysR type regulator of tsaMBCD, ... | 著者 | Monferrer, D, Tralau, T, Kertesz, M.A, Kikhney, A, Svergun, D, Uson, I. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold Mol.Microbiol., 75, 2010
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3FXU
| Crystal structure of TsaR in complex with its effector p-toluenesulfonate | 分子名称: | CHLORIDE ION, FORMIC ACID, GLYCEROL, ... | 著者 | Monferrer, D, Tralau, T, Kertesz, M.A, Kikhney, A, Svergun, D, Uson, I. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold Mol.Microbiol., 75, 2010
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3LKD
| Crystal Structure of the type I restriction-modification system methyltransferase subunit from Streptococcus thermophilus, Northeast Structural Genomics Consortium Target SuR80 | 分子名称: | Type I restriction-modification system methyltransferase subunit | 著者 | Vorobiev, S, Su, M, Seetharaman, J, Mao, M, Xiao, R, Foote, E.L, Ciccosanti, C, Wang, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-01-27 | 公開日 | 2010-02-09 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target SuR80 To be published
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6LHD
| Crystal structure of p53/BCL-xL fusion complex | 分子名称: | ZINC ION, fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53 | 著者 | Wei, H, Chen, Y. | 登録日 | 2019-12-07 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | 主引用文献 | Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nat Commun, 12, 2021
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1I6X
| STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR PROTEIN | 著者 | White, M.A, Lee, J.C, Fox, R.O. | 登録日 | 2001-03-06 | 公開日 | 2003-06-17 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The effect of the D53H point mutation on the macroscopic
motions of E. coli Cyclic AMP Receptor Protein To be Published
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1W1W
| Sc Smc1hd:Scc1-C complex, ATPgS | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, SISTER CHROMATID COHESION PROTEIN 1, ... | 著者 | Haering, C, Nasmyth, K, Lowe, J. | 登録日 | 2004-06-24 | 公開日 | 2004-09-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure and stability of cohesin's Smc1-kleisin interaction. Mol. Cell, 15, 2004
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4NN1
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5N0L
| The structure of the cofactor binding GAF domain of the nutrient sensor CodY from Clostridium difficile | 分子名称: | GTP-sensing transcriptional pleiotropic repressor CodY, ISOLEUCINE | 著者 | Levdikov, V.M, Blagova, E.V, Wilkinson, A.J, Sonenshein, A.L. | 登録日 | 2017-02-03 | 公開日 | 2018-02-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027. Plos One, 14, 2019
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4G12
| Crystal structure of putative TetR family transcriptional regulator, Fad35R, from Mycobacterium tuberculosis | 分子名称: | GLYCEROL, Probable transcriptional regulatory protein (Probably TETR-FAMILY) | 著者 | Singh, A.K, Manjasetty, B.A, Singh, V, Mittal, M, Kumaran, S. | 登録日 | 2012-07-10 | 公開日 | 2013-07-10 | 最終更新日 | 2014-10-15 | 実験手法 | X-RAY DIFFRACTION (3.44 Å) | 主引用文献 | Crystal structure of putative TetR family transcriptional regulator, Fad35R, from Mycobacterium tuberculosis to be published
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5N7O
| EthR2 in complex with SMARt-420 compound | 分子名称: | 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one, Probable transcriptional regulatory protein | 著者 | Wohlkonig, A, Wintjens, R. | 登録日 | 2017-02-21 | 公開日 | 2017-04-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2. Biochem. Biophys. Res. Commun., 487, 2017
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8FDV
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8FJ7
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8FQJ
| LSD1-CoREST in complex with T14, short soaking | 分子名称: | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4R)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-{4-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate | 著者 | Caroli, J, Mattevi, A. | 登録日 | 2023-01-06 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To be published
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8FJ4
| LSD1-CoREST in complex with T108, short soaking | 分子名称: | 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-phenylbenzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ... | 著者 | Caroli, J, Mattevi, A. | 登録日 | 2022-12-19 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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8FJ6
| LSD1-CoREST in complex with T108, long soaking | 分子名称: | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[7,8-dimethyl-2,4-dioxo-5-{3-[3-(phenylcarbamoyl)phenyl]propanoyl}-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate | 著者 | Caroli, J, Mattevi, A. | 登録日 | 2022-12-19 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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1I5Z
| STRUCTURE OF CRP-CAMP AT 1.9 A | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CATABOLITE GENE ACTIVATOR PROTEIN | 著者 | White, M.A, Lee, J.C, Fox, R.O. | 登録日 | 2001-03-01 | 公開日 | 2003-06-17 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The effect of the D53H point mutation on the macroscopic
motions of E. coli Cyclic AMP Receptor Protein To be Published
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5OCN
| Crystal structure of the forkhead domain of human FOXN1 | 分子名称: | Forkhead box protein N1, POTASSIUM ION | 著者 | Newman, J.A, Aitkenhead, H, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwwards, A, Bountra, C, Gileadi, O. | 登録日 | 2017-07-03 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the forkhead domain of human FOXN1 To be published
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8OJ8
| 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | 登録日 | 2023-03-24 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
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5G4N
| Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083 | 分子名称: | 1-[9-(2,2-difluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, GLYCEROL, ... | 著者 | Joerger, A.C, Bauer, M, Jones, R.N, Spencer, J. | 登録日 | 2016-05-13 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016
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5G4M
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4L5I
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5G4O
| Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083 | 分子名称: | CELLULAR TUMOR ANTIGEN P53, N,N-dimethyl-1-[9-(2,2,2-trifluoroethyl)-9H-carbazol-3-yl]methanamine, ZINC ION | 著者 | Joerger, A.C, Bauer, M, Baud, M.G.J, Spencer, J. | 登録日 | 2016-05-13 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016
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7LVK
| Cfr-modified 50S subunit from Escherichia coli | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Stojkovic, V, Myasnikov, A.G, Frost, A, Fujimori, D.G. | 登録日 | 2021-02-25 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Investigating antibiotic resistance of a ribosomal-RNA methylating enzyme through directed evolution To Be Published
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