8FJ6
LSD1-CoREST in complex with T108, long soaking
Summary for 8FJ6
| Entry DOI | 10.2210/pdb8fj6/pdb |
| Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[7,8-dimethyl-2,4-dioxo-5-{3-[3-(phenylcarbamoyl)phenyl]propanoyl}-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (3 entities in total) |
| Functional Keywords | epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 112550.22 |
| Authors | |
| Primary citation | Caroli, J.,Mattevi, A. Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published, |
| Experimental method |
Structure validation
Download full validation report
