5N7O

EthR2 in complex with SMARt-420 compound

Summary for 5N7O

• Entry DOI: 10.2210/pdb5n7o/pdb
• Related: 5ICJ 5N1C 5N1I
• Descriptor: Probable transcriptional regulatory protein, 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one (3 entities in total)
• Functional Keywords: repressor, complex, inhibitor, transcription
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 2
• Total formula weight: 48925.82

Authors

Wohlkonig, A.,Wintjens, R. (deposition date: 2017-02-21, release date: 2017-04-26, Last modification date: 2024-01-17)

• Primary citation: Wohlkonig, A.,Remaut, H.,Moune, M.,Tanina, A.,Meyer, F.,Desroses, M.,Steyaert, J.,Willand, N.,Baulard, A.R.,Wintjens, R.; Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.; Biochem. Biophys. Res. Commun., 487:403-408, 2017; PubMed: 28416386; DOI: 10.1016/j.bbrc.2017.04.074

Experimental method

X-RAY DIFFRACTION (2.3 Å)