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5Y7A
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Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN
分子名称: (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase
著者Xiang, Y, Gao, J.J, Zhu, D.Y.
登録日2017-08-16
公開日2017-12-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.846 Å)
主引用文献Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048
FASEB J., 32, 2018
5Y77
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Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN (seMet derivative)
分子名称: (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase
著者Xiang, Y, Gao, J.J, Zhu, D.Y.
登録日2017-08-16
公開日2017-12-27
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048
FASEB J., 32, 2018
8WKO
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Crystal structure of O-acetylhomoserine sulfhydrylase from Lactobacillus plantarum in the closed form
分子名称: (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid, L-methionine gamma-lyase, PROLINE, ...
著者Oda, K, Matoba, Y.
登録日2023-09-28
公開日2024-02-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献pH-dependent regulation of an acidophilic O -acetylhomoserine sulfhydrylase from Lactobacillus plantarum.
Appl.Environ.Microbiol., 90, 2024
8WKR
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Crystal structure of O-acetylhomoserine sulfhydrylase from Lactobacillus plantarum in the open form
分子名称: (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid, L-methionine gamma-lyase, PROLINE
著者Oda, K, Matoba, Y.
登録日2023-09-28
公開日2024-02-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献pH-dependent regulation of an acidophilic O -acetylhomoserine sulfhydrylase from Lactobacillus plantarum.
Appl.Environ.Microbiol., 90, 2024
8UXE
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Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXC
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Structure of PKA phosphorylated human RyR2-R420Q in the primed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXG
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BU of 8uxg by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXH
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Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXF
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BU of 8uxf by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the primed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXL
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Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXM
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Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8UXI
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BU of 8uxi by Molmil
Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2023-11-09
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
To Be Published
8X6P
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Isomerase Protein
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1A, SULFATE ION
著者Guven, O, Demirci, H.
登録日2023-11-21
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Isomerase Protein
To Be Published
5DT9
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Crystal structure of a putative D-Erythronate-4-Phosphate Dehydrogenase from Vibrio cholerae
分子名称: CHLORIDE ION, Erythronate-4-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Stogios, P.J, Skarina, T, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2015-09-17
公開日2015-09-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.663 Å)
主引用文献Crystal structure of a putative D-Erythronate-4-Phosphate Dehydrogenase from Vibrio cholerae
To Be Published
5EK4
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Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
分子名称: (1~{R})-1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
著者Wu, S.Y, Peng, Y.H, Wu, J.S.
登録日2015-11-03
公開日2015-12-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5EK2
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Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
分子名称: 1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanone, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
著者Peng, Y.H, Wu, J.S, Wu, S.Y.
登録日2015-11-03
公開日2015-12-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5ETW
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Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
分子名称: (1~{R})-1-cyclohexyl-2-pyrido[3,4-b]indol-9-yl-ethanol, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
著者Wu, S.Y, Peng, Y.H, Wu, J.S.
登録日2015-11-18
公開日2016-02-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
J.Med.Chem., 59, 2016
5EK3
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Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
分子名称: (1~{R})-1-cyclohexyl-2-[(5~{S})-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
著者Peng, Y.H, Wu, J.S, Wu, S.Y.
登録日2015-11-03
公開日2015-12-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.209 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5FN0
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Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180
分子名称: 3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, KYNURENINE 3-MONOOXYGENASE
著者Mole, D.J, Webster, S.P, Uings, I, Zheng, X, Binnie, M, Wilson, K, Hutchinson, J.P, Mirguet, O, Walker, A, Beaufils, B, Ancellin, N, Trottet, L, Beneton, V, Mowat, C.G, Wilkinson, M, Rowland, P, Haslam, C, McBride, A, Homer, N.Z.M, Baily, J.E, Sharp, M.G.F, Garden, O.J, Hughes, J, Howie, S.E.M, Holmes, D, Liddle, J, Iredale, J.P.
登録日2015-11-10
公開日2016-01-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.
Nat.Med. (N.Y.), 22, 2016
1U1H
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A. thaliana cobalamine independent methionine synthase
分子名称: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, METHIONINE, SULFATE ION, ...
著者Ferrer, J.-L, Ravanel, S, Robert, M, Dumas, R.
登録日2004-07-15
公開日2004-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
J.Biol.Chem., 279, 2004
1U22
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A. thaliana cobalamine independent methionine synthase
分子名称: (6S)-5,6,7,8-TETRAHYDROFOLATE, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, ...
著者Ferrer, J.-L, Ravanel, S, Robert, M, Dumas, R.
登録日2004-07-16
公開日2004-09-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
J.Biol.Chem., 279, 2004
1VKZ
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Crystal structure of Phosphoribosylamine--glycine ligase (TM1250) from Thermotoga maritima at 2.30 A resolution
分子名称: 1,2-ETHANEDIOL, Phosphoribosylamine--glycine ligase
著者Joint Center for Structural Genomics (JCSG)
登録日2004-06-29
公開日2004-08-24
最終更新日2023-01-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of Phosphoribosylamine--glycine ligase (TM1250) from Thermotoga maritima at 2.30 A resolution
To be published
1WXI
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E.coli NAD Synthetase, AMP.PP
分子名称: ADENOSINE MONOPHOSPHATE, DIPHOSPHATE, MAGNESIUM ION, ...
著者Jauch, R, Humm, A, Huber, R, Wahl, M.C.
登録日2005-01-23
公開日2005-02-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements
J.Biol.Chem., 280, 2005
1VKH
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CRYSTAL STRUCTURE OF A PUTATIVE SERINE HYDROLASE (YDR428C) FROM SACCHAROMYCES CEREVISIAE AT 1.85 A RESOLUTION
分子名称: CHLORIDE ION, GLYCEROL, putative serine hydrolase
著者Joint Center for Structural Genomics (JCSG)
登録日2004-05-20
公開日2004-06-08
最終更新日2023-01-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution
Proteins, 58, 2005
1WXG
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E.coli NAD Synthetase, DND
分子名称: MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, NICOTINIC ACID ADENINE DINUCLEOTIDE
著者Jauch, R, Humm, A, Huber, R, Wahl, M.C.
登録日2005-01-23
公開日2005-02-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements
J.Biol.Chem., 280, 2005

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