6VKS
| Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE | 著者 | Moseng, M.A, Lyu, M. | 登録日 | 2020-01-22 | 公開日 | 2020-07-01 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance. Mbio, 11, 2020
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3W9I
| Structural basis for the inhibition of bacterial multidrug exporters | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB | 著者 | Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A. | 登録日 | 2013-04-04 | 公開日 | 2013-07-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structural basis for the inhibition of bacterial multidrug exporters Nature, 500, 2013
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3W9J
| Structural basis for the inhibition of bacterial multidrug exporters | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB, [{2-[({[(3R)-1-{8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-4-oxo-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}piperidin-3-yl]oxy}carbonyl)amino]ethyl}(dimethyl)ammonio]acetate | 著者 | Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A. | 登録日 | 2013-04-04 | 公開日 | 2013-07-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural basis for the inhibition of bacterial multidrug exporters Nature, 500, 2013
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1R8D
| Crystal Structure of MtaN Bound to DNA | 分子名称: | 26-MER, SULFATE ION, transcription activator MtaN | 著者 | Newberry, K.J, Brennan, R.G. | 登録日 | 2003-10-23 | 公開日 | 2004-08-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
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8JX7
| Cryo-EM structure of human ABC transporter ABCC2 | 分子名称: | ATP-binding cassette sub-family C member 2 | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-06-30 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JY5
| Cryo-EM structure of human ABC transporter ABCC2 in apo" state | 分子名称: | ATP-binding cassette sub-family C member 2 | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-03 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JY4
| Cryo-EM structure of human ABC transporter ABCC2 in apo' state | 分子名称: | ATP-binding cassette sub-family C member 2 | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-02 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JXU
| Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 2, ... | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-01 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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8JXQ
| Cryo-EM structure of bilirubin ditaurate (BDT) bound human ABC transporter ABCC2 | 分子名称: | 2-[3-[5-[(E)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-3-[3-oxidanylidene-3-(2-sulfoethylamino)propyl]-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoylamino]ethanesulfonic acid, ATP-binding cassette sub-family C member 2, CHOLESTEROL | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-07-01 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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6IIA
| MexB in complex with LMNG | 分子名称: | Lauryl Maltose Neopentyl Glycol, Multidrug resistance protein MexB | 著者 | Nakashima, R, Sakurai, K, Nakao, K. | 登録日 | 2018-10-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds. Sci Rep, 9, 2019
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7QKS
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7QKR
| Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Dexverapamil, MAGNESIUM ION, ... | 著者 | Schleker, E.S.M, Reinhart, C. | 登録日 | 2021-12-18 | 公開日 | 2022-10-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proc.Natl.Acad.Sci.USA, 119, 2022
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4YER
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8UOZ
| EmrE structure in the TPP-bound state (WT/E14Q heterodimer) | 分子名称: | SMR family multidrug efflux protein EmrE, TETRAPHENYLPHOSPHONIUM | 著者 | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | 登録日 | 2023-10-20 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | SOLID-STATE NMR, SOLUTION NMR | 主引用文献 | Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE. Nat Commun, 15, 2024
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1NY9
| Antibiotic binding domain of a TipA-class multidrug resistance transcriptional regulator | 分子名称: | Transcriptional activator tipA-S | 著者 | Kahmann, J.D, Sass, H.J, Allan, M.G, Seto, H, Thompson, C.J, Grzesiek, S. | 登録日 | 2003-02-12 | 公開日 | 2003-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for antibiotic recognition by the TipA-class of
multidrug-resistance transcriptional regulators Embo J., 22, 2003
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6FHZ
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6HFB
| Outward-facing conformation of a multidrug resistance MATE family transporter of the MOP superfamily. | 分子名称: | CESIUM ION, Uncharacterized protein | 著者 | Nonaka, T, Zakrzewska, S, Safarian, S, Michel, H. | 登録日 | 2018-08-21 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.495 Å) | 主引用文献 | Inward-facing conformation of a multidrug resistance MATE family transporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6Z71
| Structure of the MATE family multidrug resistance transporter Aq_128 from Aquifex aeolicus in the outward-facing state | 分子名称: | Aq128 | 著者 | Zhao, J, Safarian, S, Thielmann, Y, Xie, H, Wang, J, Michel, H. | 登録日 | 2020-05-29 | 公開日 | 2021-12-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily. Proc.Natl.Acad.Sci.USA, 118, 2021
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6Z70
| Structure of the MATE family multidrug resistance transporter Aq_128 from Aquifex aeolicus in the outward-facing state | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Aq128 | 著者 | Zhao, J, Safarian, S, Thielmann, Y, Xie, H, Wang, J, Michel, H. | 登録日 | 2020-05-29 | 公開日 | 2021-12-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily. Proc.Natl.Acad.Sci.USA, 118, 2021
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5O66
| Asymmetric AcrABZ-TolC | 分子名称: | Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ... | 著者 | Du, D, Luisi, B.F. | 登録日 | 2017-06-05 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife, 6, 2017
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4MLB
| Reverse polarity of binding pocket suggests different function of a MOP superfamily transporter from Pyrococcus furiosus Vc1 (DSM3638) | 分子名称: | CHLORIDE ION, PENTAETHYLENE GLYCOL MONODECYL ETHER, PF0708 | 著者 | Malviya, V.N, Nonaka, T, Muenke, C, Koepke, J, Michel, H. | 登録日 | 2013-09-06 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | 主引用文献 | Inward-facing conformation of a multidrug resistance MATE family transporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6R72
| Crystal structure of BmrA-E504A in an outward-facing conformation | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug exporter ATP-binding cassette | 著者 | Chaptal, V, Zampieri, V, Kilburg, A, Magnard, S, Falson, P. | 登録日 | 2019-03-28 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | 主引用文献 | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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1OY8
| Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | 分子名称: | Acriflavine resistance protein B, RHODAMINE 6G | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | 登録日 | 2003-04-03 | 公開日 | 2003-05-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.63 Å) | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
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1OY6
| Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump | 分子名称: | Acriflavine resistance protein B | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | 登録日 | 2003-04-03 | 公開日 | 2003-05-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.68 Å) | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
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1OYE
| Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump | 分子名称: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Acriflavine resistance protein B | 著者 | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | 登録日 | 2003-04-03 | 公開日 | 2003-05-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
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