PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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7YEZ	In situ structure of polymerase complex of mammalian reovirus in the reloaded state 分子名称: Lambda-2 protein, Mu-2 protein, RNA helicase, ... 著者 Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. 登録日 2022-07-06 公開日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
7YEV	In situ structure of polymerase complex of mammalian reovirus in the pre-elongation state 分子名称: Lambda-2 protein, Mu-2 protein, RNA helicase, ... 著者 Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. 登録日 2022-07-06 公開日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
7YED	In situ structure of polymerase complex of mammalian reovirus in the elongation state 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Lambda-2 protein, MAGNESIUM ION, ... 著者 Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. 登録日 2022-07-05 公開日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
7YCX	The structure of INTAC-PEC complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... 著者 Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. 登録日 2022-07-02 公開日 2023-03-15 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (4.18 Å) 主引用文献 Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
8DJV	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-N-methoxy-4-oxo-1,4-dihydropyridine-2-carboxamide 分子名称: 6-bromo-3-hydroxy-N-methoxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-07-01 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8DJY	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-2-(4,5-dihydro-1H-imidazol-2-yl)-3-hydroxypyridin-4(1H)-one 分子名称: (2M)-6-bromo-2-(4,5-dihydro-1H-imidazol-2-yl)-3-hydroxypyridin-4(1H)-one, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-07-01 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8DIP	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023030 分子名称: (2P)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-06-29 公開日 2023-03-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
8DHN	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one 分子名称: (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, PA endonuclease 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-27 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7Y7P	QDE-1 in complex with RNA template, RNA primer and AMPNPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cui, R.X, Gan, J.H, Ma, J.B. 登録日 2022-06-22 公開日 2022-09-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
7Y7T	QDE-1 in complex with 12nt DNA template, ATP and 3'-dGTP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*G*AP*GP*AP*CP*CP*TP*TP*TP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Cui, R.X, Gan, J.H, Ma, J.B. 登録日 2022-06-22 公開日 2022-09-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
7Y7Q	QDE-1 in complex with RNA template, RNA primer and 3'-dGTP 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Cui, R.X, Gan, J.H, Ma, J.B. 登録日 2022-06-22 公開日 2022-09-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
7Y7R	QDE-1 in complex with DNA template, RNA primer and 3'-dGTP 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*AP*AP*CP*TP*AP*CP*CP*GP*TP*CP*GP*GP*A)-3'), ... 著者 Cui, R.X, Gan, J.H, Ma, J.B. 登録日 2022-06-22 公開日 2022-09-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
7Y7S	QDE-1 in complex with DNA template, RNA primer and AMPNPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cui, R.X, Gan, J.H, Ma, J.B. 登録日 2022-06-22 公開日 2022-09-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
8DDB	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-17 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8DDE	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-2-(1H-tetrazol-5-yl) yridine-3-ol 分子名称: (2M)-6-bromo-3-hydroxy-2-(1H-tetrazol-5-yl)pyridin-4(1H)-one, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-17 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7Y5M	The OTU domain of Tacheng Tick Virus 1 分子名称: RNA-directed RNA polymerase 著者 Li, Z, Wang, W.J, Xiao, Y.S, Sun, L.T. 登録日 2022-06-17 公開日 2023-06-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The OTU domain of Tacheng Tick Virus 1 To Be Published
8DAL	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinonitrile 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carbonitrile, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-13 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7Y38	Molecular architecture of the chikungunya virus replication complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Protease nsP2, ... 著者 Tan, Y.B, Luo, D. 登録日 2022-06-10 公開日 2022-12-14 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular architecture of the Chikungunya virus replication complex. Sci Adv, 8, 2022
8A40	Structure of mammalian Pol II-TFIIS elongation complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. 登録日 2022-06-09 公開日 2023-08-23 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol.Cell, 82, 2022
8A3L	Structural insights into the binding of bS1 to the ribosome 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... 著者 D'Urso, G, Chat, S, Gillet, R, Giudice, E. 登録日 2022-06-08 公開日 2023-05-10 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 Structural insights into the binding of bS1 to the ribosome. Nucleic Acids Res., 51, 2023
8CXG	Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy 分子名称: Ankyrin repeat family A protein 2,Envelope E protein, C8 scFv heavy chain, C8 scFv light chain, ... 著者 Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. 登録日 2022-05-21 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
8CXH	Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy 分子名称: Ankyrin repeat family A protein 2,Envelope E protein, C10 heavy chain, C10 light chain, ... 著者 Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. 登録日 2022-05-21 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
8CXI	Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy 分子名称: A11 heavy chain, A11 light chain, Ankyrin repeat family A protein 2,Envelope E protein, ... 著者 Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. 登録日 2022-05-21 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
7ZX7	Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. 登録日 2022-05-20 公開日 2022-11-30 最終更新日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
7ZX8	Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. 登録日 2022-05-20 公開日 2022-12-07 最終更新日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022

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