9BS4

DNA Ligase 1 E346A/E592A double mutant with 5'-rG:C

Summary for 9BS4

• Entry DOI: 10.2210/pdb9bs4/pdb
• Descriptor: DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*G)-3'), DNA/RNA (5'-R(P*G)-D(P*TP*CP*GP*GP*AP*C)-3'), ... (6 entities in total)
• Functional Keywords: dna binding protein, dna repair, ber, human dna ligase 1, ligase, ligase-dna complex, ligase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 165870.64

Authors

KanalElamparithi, B.,Caglayan, M. (deposition date: 2024-05-12, release date: 2024-09-25)

• Primary citation: Balu, K.E.,Tang, Q.,Almohdar, D.,Ratcliffe, J.,Kalaycioglu, M.,Caglayan, M.; Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.; J.Biol.Chem., 300:107688-107688, 2024; PubMed: 39159820; DOI: 10.1016/j.jbc.2024.107688

Experimental method

X-RAY DIFFRACTION (2.4 Å)