5MYC
 
 | | Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. | | 登録日 | 2017-01-26 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.459 Å) | | 主引用文献 | Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
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5MXO
 | | Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A | | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... | | 著者 | Andrei, S, Ottmann, C, Leysen, S. | | 登録日 | 2017-01-24 | | 公開日 | 2017-11-08 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
FEBS Lett., 591, 2017
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5MY9
 | | Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. | | 登録日 | 2017-01-26 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.327 Å) | | 主引用文献 | Structural interface between LRRK2 and 14-3-3 protein.
Biochem. J., 474, 2017
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5N5T
 | | 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV2 | | 分子名称: | 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyphenol, CHLORIDE ION, ... | | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | | 登録日 | 2017-02-14 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
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5N10
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5N5W
 | | 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3 | | 分子名称: | 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyaniline, CALCIUM ION, ... | | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | | 登録日 | 2017-02-14 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
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5N75
 | | 14-3-3 sigma in complex with TAZ pS89 peptide | | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | | 登録日 | 2017-02-19 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
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5N5R
 | | 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1 | | 分子名称: | 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ... | | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | | 登録日 | 2017-02-14 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
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5NAS
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5NWI
 | | 14-3-3c in complex with CPP | | 分子名称: | 14-3-3 c-1 protein, ACETATE ION, Potassium channel KAT1 | | 著者 | Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. | | 登録日 | 2017-05-06 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
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5OEG
 | | Molecular tweezers modulate 14-3-3 protein-protein interactions | | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION | | 著者 | Bier, D, Ottmann, C. | | 登録日 | 2017-07-07 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Molecular tweezers modulate 14-3-3 protein-protein interactions.
Nat Chem, 5, 2013
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5NWK
 | | 14-3-3c in complex with CPP and fusicoccin | | 分子名称: | 14-3-3 c-1 protein, FUSICOCCIN, PHOSPHOSERINE, ... | | 著者 | Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. | | 登録日 | 2017-05-06 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
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8C1Y
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8BZE
 | | FC-J stabilizer for ERa and 14-3-3 | | 分子名称: | (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-4,9-bis(oxidanyl)-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]oxy]-6-(2-methylbut-3-en-2-yloxymethyl)oxane-3,4,5-triol, 14-3-3 protein sigma, ERalpha peptide, ... | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a new potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8BZD
 | | deAc-FC stabilizer of 14-3-3 and ERalpha | | 分子名称: | 14-3-3 protein sigma, De-acetylated Fusicoccin, ERalpha peptide, ... | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8BZT
 | | FC-NAg stabilizer of 14-3-3 and ERalpha | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-15 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8BZH
 | | FC-NAc stabilizer of 14-3-3 and ERalpha | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8BZG
 | | FC-31 stabilizer of 14-3-3 and ERalpha | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ... | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-14 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8C0L
 | | FC-THF stabilizer of 14-3-3 and ERalpha | | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin A-THF | | 著者 | Visser, E.J, Ottmann, C. | | 登録日 | 2022-12-17 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
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8DGN
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8DGM
 | | 14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide | | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 | | 著者 | Roy, M.J, Hardy, J.M, Lucet, I.S. | | 登録日 | 2022-06-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Nat Commun, 14, 2023
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8DGP
 | | 14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide | | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... | | 著者 | Roy, M.J, Hardy, J.M, Lucet, I.S. | | 登録日 | 2022-06-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.
Nat Commun, 14, 2023
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8DP5
 | | Structure of the PEAK3/14-3-3 complex | | 分子名称: | 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... | | 著者 | Torosyan, H, Paul, M, Jura, N, Verba, K.A. | | 登録日 | 2022-07-14 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nat Commun, 14, 2023
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8EQ8
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8EQH
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