PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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6UJ4	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction 分子名称: 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 著者 Zhao, B. 登録日 2019-10-02 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJL	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction 分子名称: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5 著者 Phan, J. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 分子名称: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 著者 Zhao, B, Wang, F. 登録日 2019-09-05 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UJJ	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction 分子名称: 5-[4-(trifluoromethyl)phenyl]-1H-tetrazole, WD repeat-containing protein 5 著者 Phan, J. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.731 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UHY	WDR5 in complex with Myc site fragment inhibitor 分子名称: 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 著者 Wang, F, Fesik, S.W. 登録日 2019-09-29 公開日 2020-04-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UCQ	Crystal structure of the Thermus thermophilus 70S ribosome recycling complex 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Zhou, D, Tanzawa, T, Gagnon, M.G, Lin, J. 登録日 2019-09-17 公開日 2019-12-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis for ribosome recycling by RRF and tRNA. Nat.Struct.Mol.Biol., 27, 2020
6UHZ	WDR5 in complex with Myc site fragment inhibitor 分子名称: 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 著者 Wang, F, Fesik, S.w. 登録日 2019-09-29 公開日 2020-04-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.258 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UO1	Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Batool, Z, Dobosz-Bartoszek, M, Polikanov, Y.S. 登録日 2019-10-14 公開日 2019-11-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Pseudouridinylation of mRNA coding sequences alters translation. Proc.Natl.Acad.Sci.USA, 116, 2019
4RDU	Crystal structure of a distal-less homeobox protein 5 (Dlx5) from Homo sapiens at 1.85 A resolution 分子名称: (DC)(DG)(DA)(DC)(DT)(DA)(DA)(DT)(DT)(DA)(DG)(DT)(DC)(DG), Homeobox protein DLX-5 著者 Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL) 登録日 2014-09-19 公開日 2014-11-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of a distal-less homeobox protein 5 (Dlx5) from Homo sapiens at 1.85 A resolution To be published
6LSS	Cryo-EM structure of a pre-60S ribosomal subunit - state preA 分子名称: 28S rRNA, 5S rRNA, 60S ribosomal protein L11, ... 著者 Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N. 登録日 2020-01-20 公開日 2020-08-26 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun, 11, 2020
5NBC	Structure of Prokaryotic Transcription Factors 分子名称: Ferric uptake regulation protein, MANGANESE (II) ION, ZINC ION 著者 Perard, J, Carpentier, P, Michaud-Soret, I, Cavazza, C. 登録日 2017-03-01 公開日 2018-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role inFrancisella tularensisvirulence. Commun Biol, 1, 2018
3TPD	Structure of pHipA, monoclinic form 分子名称: CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA 著者 schumacher, M.A, link, T, Brennan, R.G. 登録日 2011-09-07 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
3TPT	Structure of HipA(D309Q) bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... 著者 schumacher, M.A, link, T, Brennan, R.G. 登録日 2011-09-08 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
6KPD	The crystal structure of the BALDIBIS/IDD9 bound to the homodimeric SCL3 分子名称: Peptide from Zinc finger protein BALDIBIS, Scarecrow-like protein 3 著者 Hirano, Y, Shimizu, R, Hakoshima, T. 登録日 2019-08-15 公開日 2020-09-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the SCL3 homodimer bound to the BIRD/IDD transcription factor To Be Published
6KZI	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives 分子名称: 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Wan, X, Li, W, Xie, Y, Huang, N. 登録日 2019-09-24 公開日 2020-03-04 最終更新日 2021-03-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
6L15	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-05-27 最終更新日 2020-07-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
6L12	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 4-[(2-chloranylphenoxazin-10-yl)methyl]cyclohexan-1-amine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-05-27 最終更新日 2020-07-08 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
6KPB	The crystal structure of the JACKDAW/IDD10 bound to the homodimeric SCL3 分子名称: DI(HYDROXYETHYL)ETHER, Peptide from Zinc finger protein JACKDAW, Scarecrow-like protein 3 著者 Hirano, Y, Hakoshima, T. 登録日 2019-08-15 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the SCL3 homodimer bound to the BIRD/IDD transcription factor To Be Published
6L16	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl)ethyl]piperidin-1-yl]ethanamine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-05-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
6L17	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazin-8-amine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-09-02 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
6L11	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 5-(2-chloranylphenoxazin-10-yl)-~{N},~{N}-diethyl-pentan-1-amine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-05-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
5YC9	Crystal structure of a Pseudomonas aeruginosa transcriptional regulator 分子名称: C-di-GMP-binding multidrug transporter transcriptional regulator BrlR 著者 Harikiran, R, Rohan, S. 登録日 2017-09-07 公開日 2019-03-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of a Pseudomonas aeruginosa transcriptional regulator To Be Published
3KTB	Crystal Structure of Arsenical Resistance Operon Trans-acting Repressor from Bacteroides vulgatus ATCC 8482 分子名称: ACETIC ACID, Arsenical resistance operon trans-acting repressor, CALCIUM ION, ... 著者 Kim, Y, Tesar, C, Feldmann, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-11-24 公開日 2009-12-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Arsenical Resistance Operon Trans-acting Repressor from Bacteroides vulgatus ATCC 8482 To be Published
3KIK	Sgf11:Sus1 complex 分子名称: Protein SUS1, SAGA-associated factor 11 著者 Stewart, M, Ellisdon, A.M. 登録日 2009-11-02 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1 J.Biol.Chem., 285, 2010
3KNA	M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA 分子名称: 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... 著者 Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R. 登録日 2009-11-12 公開日 2010-07-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010

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