6UO1
Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution
This is a non-PDB format compatible entry.
Summary for 6UO1
Entry DOI | 10.2210/pdb6uo1/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (59 entities in total) |
Functional Keywords | pseudouridine, mrna, modification, ribosome, translation, peptidyl transferase center, trna accommodation |
Biological source | Thermus thermophilus HB8 More |
Total number of polymer chains | 112 |
Total formula weight | 4537656.70 |
Authors | Batool, Z.,Dobosz-Bartoszek, M.,Polikanov, Y.S. (deposition date: 2019-10-14, release date: 2019-11-27, Last modification date: 2023-11-15) |
Primary citation | Eyler, D.E.,Franco, M.K.,Batool, Z.,Wu, M.Z.,Dubuke, M.L.,Dobosz-Bartoszek, M.,Jones, J.D.,Polikanov, Y.S.,Roy, B.,Koutmou, K.S. Pseudouridinylation of mRNA coding sequences alters translation. Proc.Natl.Acad.Sci.USA, 116:23068-23074, 2019 Cited by PubMed: 31672910DOI: 10.1073/pnas.1821754116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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