6QCD
| Human Sirt6 in complex with ADP-ribose and the activator quercetin | 分子名称: | 1,2-ETHANEDIOL, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2018-12-27 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
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6QCB
| Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 9 | 分子名称: | (3~{S},7~{S},8~{S})-7-oxidanyl-8-(phenylmethyl)-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin D, ... | 著者 | Brynda, J, Houstecka, R, Majer, P, Mares, M. | 登録日 | 2018-12-27 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis. J.Med.Chem., 63, 2020
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6K5Q
| Crystal structure of lysozyme complexed with a bioactive compound from Jatropha gossypiifolia | 分子名称: | ACETATE ION, GLYCEROL, Lysozyme C, ... | 著者 | Kanal Elamparithi, B, Ankur, T, Sivakumar, M, Gunasekaran, K. | 登録日 | 2019-05-30 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.177 Å) | 主引用文献 | Crystal structure of lysozyme complexed with a bioactive compound from Jatropha gossypiifolia To Be Published
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6KEC
| Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one | 分子名称: | 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Lee, B.I, Park, T.H. | 登録日 | 2019-07-04 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26, 2021
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6QCT
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4V4U
| The quasi-atomic model of Human Adenovirus type 5 capsid | 分子名称: | HEXON PROTEIN, N-TERMINAL PEPTIDE OF FIBER PROTEIN, PENTON PROTEIN | 著者 | Fabry, C.M.S, Rosa-Calatrava, M, Conway, J.F, Zubieta, C, Cusack, S, Ruigrok, R.W.H, Schoehn, G. | 登録日 | 2005-03-03 | 公開日 | 2014-07-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | A Quasi-Atomic Model of Human Adenovirus Type 5 Capsid. Embo J., 24, 2005
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6QCE
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6QCH
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1D90
| REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS | 分子名称: | DNA (5'-D(*GP*GP*IP*GP*CP*TP*CP*C)-3') | 著者 | Cruse, W.B.T, Aymani, J, Kennard, O, Brown, T, Jack, A.G.C, Leonard, G.A. | 登録日 | 1992-10-17 | 公開日 | 1993-07-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs. Nucleic Acids Res., 17, 1989
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6K7K
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | 登録日 | 2019-06-07 | 公開日 | 2019-08-28 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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4V7N
| Glycocyamine kinase, beta-beta homodimer from marine worm Namalycastis sp., with transition state analog Mg(II)-ADP-NO3-glycocyamine. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANIDINO ACETATE, Glycocyamine kinase beta chain, ... | 著者 | Lim, K, Pullalarevu, S, Herzberg, O. | 登録日 | 2009-12-15 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the mechanism and substrate specificity of glycocyamine kinase, a phosphagen kinase family member. Biochemistry, 49, 2010
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6KGA
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6QCM
| Cryo em structure of the Listeria stressosome | 分子名称: | RsbR protein, RsbR protein,RsbR protein, RsbS protein | 著者 | Williams, A.H, Redzej, A, Waksman, G, Cossart, P. | 登録日 | 2018-12-28 | 公開日 | 2019-08-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | 主引用文献 | The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nat Commun, 10, 2019
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6K7X
| Human MCU-EMRE complex | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, CALCIUM ION, CARDIOLIPIN, ... | 著者 | Zhuo, W, Zhou, H, Yang, M. | 登録日 | 2019-06-10 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structure of intact human MCU supercomplex with the auxiliary MICU subunits. Protein Cell, 12, 2021
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4V6H
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1D7X
| CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR. | 分子名称: | CALCIUM ION, N-HYDROXY 1N(4-METHOXYPHENYL)SULFONYL-4-(Z,E-N-METHOXYIMINO)PYRROLIDINE-2R-CARBOXAMIDE, STROMELYSIN-1 PRECURSOR, ... | 著者 | Cheng, M.Y, Natchus, M.G, De, B, Almstead, N.G, Pikul, S. | 登録日 | 1999-10-20 | 公開日 | 2000-10-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. J.Med.Chem., 42, 1999
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1CHJ
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6QG4
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6QG6
| Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model D) | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | 著者 | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | 登録日 | 2019-01-10 | 公開日 | 2019-06-26 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (10.4 Å) | 主引用文献 | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6KEH
| Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one | 分子名称: | 6,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Lee, B.I, Park, T.H. | 登録日 | 2019-07-04 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.553 Å) | 主引用文献 | Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26, 2021
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4W9Y
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6KEJ
| Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one | 分子名称: | 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Lee, B.I, Park, T.H. | 登録日 | 2019-07-04 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26, 2021
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1CKL
| N-TERMINAL TWO DOMAINS OF HUMAN CD46 (MEMBRANE COFACTOR PROTEIN, MCP) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Casasnovas, J, Larvie, M, Stehle, T. | 登録日 | 1999-04-22 | 公開日 | 1999-06-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structure of two CD46 domains reveals an extended measles virus-binding surface. EMBO J., 18, 1999
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6QFR
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1CL6
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