6KEC

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one

Summary for 6KEC

Entry DOI	10.2210/pdb6kec/pdb
Descriptor	Bromodomain-containing protein 4, 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one, FORMIC ACID, ... (4 entities in total)
Functional Keywords	brd4, bromodomain, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15562.70
Authors	Lee, B.I.,Park, T.H. (deposition date: 2019-07-04, release date: 2020-07-08, Last modification date: 2023-11-22)
Primary citation	Yoo, M.,Park, T.H.,Yoo, M.,Kim, Y.,Lee, J.Y.,Lee, K.M.,Ryu, S.E.,Lee, B.I.,Jung, K.Y.,Park, C.H. Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26:-, 2021 Cited by PubMed: 33802888 DOI: 10.3390/molecules26061686 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation