6KEC
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 4-ethoxy-5,16-dimethoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue D9C A 401 |
Chain | Residue |
A | TRP81 |
A | HOH516 |
A | HOH535 |
A | HOH593 |
A | PRO82 |
A | VAL87 |
A | LEU92 |
A | ASP96 |
A | LYS99 |
A | ASN140 |
A | ILE146 |
A | FMT404 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue FMT A 402 |
Chain | Residue |
A | THR60 |
A | GLN62 |
A | ASN121 |
A | ALA122 |
A | HOH554 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue FMT A 403 |
Chain | Residue |
A | PRO56 |
A | LYS57 |
A | LYS99 |
A | LYS102 |
A | HOH506 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue FMT A 404 |
Chain | Residue |
A | GLN85 |
A | D9C401 |
A | HOH509 |
A | HOH528 |
A | HOH547 |
A | HOH587 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue FMT A 405 |
Chain | Residue |
A | TYR137 |
A | GLU163 |
A | HOH538 |
Functional Information from PROSITE/UniProt
site_id | PS00633 |
Number of Residues | 60 |
Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
Chain | Residue | Details |
A | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASN140 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS99 | |