4W9Y
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47
Summary for 4W9Y
Entry DOI | 10.2210/pdb4w9y/pdb |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, glutamyl sulfamide, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 82732.82 |
Authors | Pavlicek, J.,Barinka, C. (deposition date: 2014-08-28, release date: 2015-09-23, Last modification date: 2024-01-31) |
Primary citation | Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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