4W9Y

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a glutamyl sulfamide inhibitor CJC47

Summary for 4W9Y

Entry DOI	10.2210/pdb4w9y/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, glutamyl sulfamide, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	82732.82
Authors	Pavlicek, J.,Barinka, C. (deposition date: 2014-08-28, release date: 2015-09-23, Last modification date: 2024-01-31)
Primary citation	Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368 DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation