8FEN
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![BU of 8fen by Molmil](/molmil-images/mine/8fen) | Panicum vigratum Dihydroflavonol 4-reductase complexed with NADP and DHQ | 分子名称: | (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Panicum virgatum Dihydroflavonol 4-Reductase | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2022-12-06 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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3IUB
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![BU of 3iub by Molmil](/molmil-images/mine/3iub) | Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-Methoxy-N-(5-methylpyridin-2-ylsulfonyl)-1H-indole-2-carboxamide | 分子名称: | 1,2-ETHANEDIOL, 5-methoxy-N-[(5-methylpyridin-2-yl)sulfonyl]-1H-indole-2-carboxamide, ETHANOL, ... | 著者 | Silvestre, H.L, Hung, A.W, Wen, S, Ciulli, A, Blundell, T.L, Abell, C. | 登録日 | 2009-08-31 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew.Chem.Int.Ed.Engl., 48, 2009
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3EGO
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![BU of 3ego by Molmil](/molmil-images/mine/3ego) | Crystal structure of Probable 2-dehydropantoate 2-reductase panE from Bacillus Subtilis | 分子名称: | Probable 2-dehydropantoate 2-reductase | 著者 | Ramagopal, U.A, Toro, R, Gilmore, M, Hu, S, Maletic, M, Gheyi, T, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2008-09-11 | 公開日 | 2008-09-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of Probable 2-dehydropantoate 2-reductase panE from Bacillus Subtilis To be published
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8EST
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![BU of 8est by Molmil](/molmil-images/mine/8est) | REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN | 分子名称: | CALCIUM ION, ETHYL-(2-CARBOXY-4-GUANIDINIUM-PHENYL)-CHLOROACETATE, PORCINE PANCREATIC ELASTASE, ... | 著者 | Radhakrishnan, R, Powers, J.C, Meyerjunior, E.F. | 登録日 | 1990-02-21 | 公開日 | 1992-10-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry, 29, 1990
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1K6E
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![BU of 1k6e by Molmil](/molmil-images/mine/1k6e) | COMPLEX OF HYDROLYTIC HALOALKANE DEHALOGENASE LINB FROM SPHINGOMONAS PAUCIMOBILIS UT26 WITH 1,2-PROPANEDIOL (PRODUCT OF DEHALOGENATION OF 1,2-DIBROMOPROPANE) AT 1.85A | 分子名称: | 1-BROMOPROPANE-2-OL, BROMIDE ION, CHLORIDE ION, ... | 著者 | Streltsov, V.A, Prokop, Z, Damborsky, J, Nagata, Y, Oakley, A, Wilce, M.C.J. | 登録日 | 2001-10-16 | 公開日 | 2003-08-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates. Biochemistry, 42, 2003
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1QR0
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![BU of 1qr0 by Molmil](/molmil-images/mine/1qr0) | CRYSTAL STRUCTURE OF THE 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP-COENZYME A COMPLEX | 分子名称: | 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP, COENZYME A, MAGNESIUM ION | 著者 | Reuter, K, Mofid, R.M, Marahiel, A.M, Ficner, R. | 登録日 | 1999-06-17 | 公開日 | 1999-12-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily. EMBO J., 18, 1999
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1F2J
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![BU of 1f2j by Molmil](/molmil-images/mine/1f2j) | CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI | 分子名称: | FRUCTOSE-BISPHOSPHATE ALDOLASE, GLYCOSOMAL | 著者 | Chudzik, D.M, Michels, P.A, De Walque, S, Hol, W.G.J. | 登録日 | 2000-05-25 | 公開日 | 2000-07-13 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases. J.Mol.Biol., 300, 2000
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1OU6
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![BU of 1ou6 by Molmil](/molmil-images/mine/1ou6) | |
5YG2
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![BU of 5yg2 by Molmil](/molmil-images/mine/5yg2) | Plasmodium vivax SHMT bound with PLP-glycine and GS705 | 分子名称: | 3-[1-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-fluoranyl-phenyl]piperidin-4-yl]propanoic acid, CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Schwertz, G, Diederich, F. | 登録日 | 2017-09-22 | 公開日 | 2018-06-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold ChemMedChem, 13, 2018
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1KPG
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![BU of 1kpg by Molmil](/molmil-images/mine/1kpg) | Crystal Structure of mycolic acid cyclopropane synthase CmaA1 complexed with SAH and CTAB | 分子名称: | CARBONATE ION, CETYL-TRIMETHYL-AMMONIUM, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1, ... | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2001-12-30 | 公開日 | 2002-01-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis J.Biol.Chem., 277, 2002
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3F3M
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![BU of 3f3m by Molmil](/molmil-images/mine/3f3m) | |
4CRZ
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![BU of 4crz by Molmil](/molmil-images/mine/4crz) | Direct visualisation of strain-induced protein prost-translational modification | 分子名称: | ACETYL COENZYME *A, ASPARTATE 1-DECARBOXYLASE, MAGNESIUM ION, ... | 著者 | Monteiro, D.C.F, Patel, V, Bartlett, C.P, Grant, T.D, Nozaki, S, Gowdy, J.A, Snell, E.H, Niki, H, Pearson, A.R, Webb, M.E. | 登録日 | 2014-03-02 | 公開日 | 2015-03-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Structure of the Pand/Panz Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A. Chem.Biol., 22, 2015
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4CS0
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![BU of 4cs0 by Molmil](/molmil-images/mine/4cs0) | Direct visualisation of strain-induced protein post-translational modification | 分子名称: | ACETYL COENZYME *A, ASPARTATE 1-DECARBOXYLASE, MAGNESIUM ION, ... | 著者 | Monteiro, D.C.F, Patel, V, Bartlett, C.P, Grant, T.D, Nozaki, S, Gowdy, J.A, Snell, E.H, Niki, H, Pearson, A.R, Webb, M.E. | 登録日 | 2014-03-02 | 公開日 | 2015-03-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Structure of the Pand/Panz Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A. Chem.Biol., 22, 2015
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3JW1
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![BU of 3jw1 by Molmil](/molmil-images/mine/3jw1) | Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution | 分子名称: | Ribonuclease pancreatic, URIDINE-5'-MONOPHOSPHATE | 著者 | Larson, S.B, Day, J.S, Nguyen, C, Cudney, R, Mcpherson, A, Center for High-Throughput Structural Biology (CHTSB) | 登録日 | 2009-09-17 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution. Acta Crystallogr.,Sect.F, 66, 2010
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7FTD
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![BU of 7ftd by Molmil](/molmil-images/mine/7ftd) | SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with Z27782662 | 分子名称: | 1,2-ETHANEDIOL, ALANINE, D-GLUTAMIC ACID, ... | 著者 | Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. | 登録日 | 2023-01-24 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | SDCBP PanDDA analysis group deposition To Be Published
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3KSL
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![BU of 3ksl by Molmil](/molmil-images/mine/3ksl) | Structure of FPT bound to DATFP-DH-GPP | 分子名称: | (2S,6E)-8-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-2,6-dimethyloct-6-en-1-yl (2S)-3,3,3-trifluoro-2-hydrazinopropanoate, Farnesyltransferase, CAAX box, ... | 著者 | Hovlid, M.L, Edelstein, R.L, Henry, O, Ochocki, J, DeGraw, A, Lenevich, S, Talbot, T, Young, V, Hruza, A.W, Lopez-Gallego, F, Labello, N.P, Strickland, C.L, Schmidt-Dannert, C, Distefano, M.D. | 登録日 | 2009-11-23 | 公開日 | 2009-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chem.Biol.Drug Des., 75, 2010
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3L2L
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![BU of 3l2l by Molmil](/molmil-images/mine/3l2l) | X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Limit Dextrin and Oligosaccharide | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | 著者 | Larson, S.B, Day, J.S, McPherson, A. | 登録日 | 2009-12-15 | 公開日 | 2010-04-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin. Biochemistry, 49, 2010
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3L2M
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![BU of 3l2m by Molmil](/molmil-images/mine/3l2m) | X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Alpha-cyclodextrin | 分子名称: | CALCIUM ION, CHLORIDE ION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), ... | 著者 | Larson, S.B, Day, J.S, McPherson, A. | 登録日 | 2009-12-15 | 公開日 | 2010-04-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin. Biochemistry, 49, 2010
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6AKY
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![BU of 6aky by Molmil](/molmil-images/mine/6aky) | The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 34 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-3-yl)propyl]cyclohexane-1-carboxamide, C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ... | 著者 | Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2018-09-04 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. J. Med. Chem., 61, 2018
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2F8W
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![BU of 2f8w by Molmil](/molmil-images/mine/2f8w) | Crystal structure of d(CACGTG)2 | 分子名称: | 1,3-DIAMINOPROPANE, 5'-D(*CP*AP*CP*GP*TP*G)-3', SPERMINE | 著者 | Narayana, N, Shamala, N, Ganesh, K.N, Viswamitra, M.A. | 登録日 | 2005-12-04 | 公開日 | 2006-01-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Interaction between the Z-Type DNA Duplex and 1,3-Propanediamine: Crystal Structure of d(CACGTG)2 at 1.2 A Resolution Biochemistry, 45, 2006
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3IJ8
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![BU of 3ij8 by Molmil](/molmil-images/mine/3ij8) | Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-04 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
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5XMR
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![BU of 5xmr by Molmil](/molmil-images/mine/5xmr) | Plasmodium vivax SHMT(C346A) bound with PLP-glycine and GS395 | 分子名称: | (4~{S})-6-azanyl-3-methyl-4-[3-[4-(phenylmethyl)sulfonylphenyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2 ,3-c]pyrazole-5-carbonitrile, CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Schwertz, G, Diederich, F. | 登録日 | 2017-05-16 | 公開日 | 2017-11-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs Chemistry, 23, 2017
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3IJ7
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![BU of 3ij7 by Molmil](/molmil-images/mine/3ij7) | Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | 4-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosyl fluoride, 4-O-methyl-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-03 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
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3IJ9
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![BU of 3ij9 by Molmil](/molmil-images/mine/3ij9) | Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, CALCIUM ION, CHLORIDE ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-04 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
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5X7D
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![BU of 5x7d by Molmil](/molmil-images/mine/5x7d) | Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liu, X, Ahn, S, Kahsai, A.W, Meng, K.-C, Latorraca, N.R, Pani, B, Venkatakrishnan, A.J, Masoudi, A, Weis, W.I, Dror, R.O, Chen, X, Lefkowitz, R.J, Kobilka, B.K. | 登録日 | 2017-02-25 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure. Nature, 548, 2017
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