8B54
 
 | | CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 | | 分子名称: | 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... | | 著者 | Djukic, S, Skerlova, J, Rezacova, P. | | 登録日 | 2022-09-21 | | 公開日 | 2023-03-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomed Pharmacother, 161, 2023
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6ZUZ
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5XZF
 | | Vitamin D receptor with a synthetic ligand ADRO1 | | 分子名称: | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6S)-6-(1-adamantyl)-6-oxidanyl-hex-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, FORMIC ACID, Mediator of RNA polymerase II transcription subunit 1, ... | | 著者 | Otero, R, Numoto, N, Ikura, T, Yamada, S, Mourino, A, Makishima, M, Ito, N. | | 登録日 | 2017-07-12 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | 25 S-Adamantyl-23-yne-26,27-dinor-1 alpha ,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.
J. Med. Chem., 61, 2018
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3NFQ
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2L2I
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2GD7
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6WJV
 | | Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | | 分子名称: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... | | 著者 | Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. | | 登録日 | 2020-04-14 | | 公開日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome.
Nat Commun, 11, 2020
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1HEI
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2XGP
 | | Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA | | 分子名称: | 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... | | 著者 | Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T. | | 登録日 | 2010-06-07 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2XGQ
 | | Structure of yeast DNA polymerase eta in complex with C8-N-acetyl-2- aminoanthracene containing DNA | | 分子名称: | 5'-D(*CP*8AG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... | | 著者 | Schneider, S, Schorr, S, Carell, T. | | 登録日 | 2010-06-07 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1D8K
 | | SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA | | 分子名称: | GENERAL TRANSCRIPTION FACTOR TFIIE-BETA | | 著者 | Okuda, M, Watanabe, Y, Okamura, H, Hanaoka, F, Ohkuma, Y, Nishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1999-10-25 | | 公開日 | 2000-04-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface.
EMBO J., 19, 2000
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1D8J
 | | SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA | | 分子名称: | GENERAL TRANSCRIPTION FACTOR TFIIE-BETA | | 著者 | Okuda, M, Watanabe, Y, Okamura, H, Hanaoka, F, Ohkuma, Y, Nishimura, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1999-10-25 | | 公開日 | 2000-04-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface.
EMBO J., 19, 2000
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8VRJ
 | | Rigid body fitted model for gamma tubulin ring complex capped microtubule | | 分子名称: | Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... | | 著者 | Aher, A, Urnavicius, L, Kapoor, T.M. | | 登録日 | 2024-01-22 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | | 主引用文献 | Structure of the gamma-tubulin ring complex-capped microtubule.
Nat.Struct.Mol.Biol., 31, 2024
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8VRK
 | | Rigid body fitted model for refined density map of gamma tubulin ring complex capped microtubule | | 分子名称: | Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... | | 著者 | Aher, A, Urnavicius, L, Kapoor, T.M. | | 登録日 | 2024-01-22 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | | 主引用文献 | Structure of the gamma-tubulin ring complex-capped microtubule.
Nat.Struct.Mol.Biol., 31, 2024
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3NCI
 | | RB69 DNA Polymerase Ternary Complex with dCTP Opposite dG at 1.8 angstrom resolution | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... | | 著者 | Wang, M, Blaha, G, Steitz, T.A, Konigsberg, W.H, Wang, J. | | 登録日 | 2010-06-04 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Insights into base selectivity from the 1.8 A resolution structure of an RB69 DNA polymerase ternary complex.
Biochemistry, 50, 2011
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1HUZ
 | | CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP | | 分子名称: | 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*CP*T)-3', CHROMIUM ION, ... | | 著者 | Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K. | | 登録日 | 2001-01-04 | | 公開日 | 2001-04-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
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8H93
 | | Structure of dimeric mouse SCMC core complex | | 分子名称: | NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | | 著者 | Chi, P, Ou, G, Han, Z, Li, J, Deng, D. | | 登録日 | 2022-10-24 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural basis of the subcortical maternal complex and its implications in reproductive disorders.
Nat.Struct.Mol.Biol., 31, 2024
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7U2P
 | | Structure of TcdA GTD in complex with RhoA | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Glucosyltransferase TcdA, MAGNESIUM ION, ... | | 著者 | Baohua, C, Zheng, L, Kay, P, Rongsheng, J. | | 登録日 | 2022-02-24 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.596 Å) | | 主引用文献 | Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition.
Sci Rep, 12, 2022
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6QK7
 | | Elongator catalytic subcomplex Elp123 lobe | | 分子名称: | 5'-DEOXYADENOSINE, Elongator complex protein 1, Elongator complex protein 2, ... | | 著者 | Dauden, M.I, Jaciuk, M, Glatt, S. | | 登録日 | 2019-01-28 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis of tRNA recognition by the Elongator complex.
Sci Adv, 5, 2019
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4E3S
 | | RB69 DNA Polymerase Ternary Complex with dQTP Opposite dT | | 分子名称: | 3-{2-deoxy-5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-7-methyl-3H-imidazo[4,5-b]pyridine, CALCIUM ION, DNA polymerase, ... | | 著者 | Xia, S, Wang, J, Konigsberg, W.H. | | 登録日 | 2012-03-10 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA.
Biochemistry, 51, 2012
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2DB9
 | | Solution structure of the plus-3 domain of human KIAA0252 protein | | 分子名称: | Paf1/RNA polymerase II complex component | | 著者 | Yoneyama, M, Kigawa, T, Tochio, N, Nameki, N, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-12-15 | | 公開日 | 2006-06-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the plus-3 domain of human KIAA0252 protein
To be Published
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8T1R
 | | Crystal structure of human CPSF73 catalytic segment in complex with compound 2 | | 分子名称: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | | 著者 | Huang, J, Tong, L. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
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8T1Q
 | | Crystal structure of human CPSF73 catalytic segment in complex with compound 1 | | 分子名称: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(4-ethanoylphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | | 著者 | Huang, J, Tong, L. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
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2V4R
 | | Non-productive complex of the Y-family DNA polymerase Dpo4 with dGTP skipping the M1dG adduct to pair with the next template cytosine | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(*TP*CP*AP*CP*M1GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | | 著者 | Eoff, R.L, Stafford, J.B, Szekely, J, Rizzo, C.J, Egli, M, Guengerich, F.P, Marnett, L.J. | | 登録日 | 2008-09-26 | | 公開日 | 2009-06-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and Functional Analysis of Sulfolobus Solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde-Deoxyguanosine Adduct.
Biochemistry, 48, 2009
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1HUO
 | | CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP | | 分子名称: | 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*C)-3', CHROMIUM ION, ... | | 著者 | Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K. | | 登録日 | 2001-01-04 | | 公開日 | 2001-04-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
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