PDB: 41592 件ウェブページステータス検索Chemie searchBIRD

---

6S66	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 分子名称: 1-(2-azanylethyl)-3-(3,4-dichlorophenyl)-~{N}-(phenylmethyl)pyrazole-4-carboxamide, MYRISTIC ACID, Transcriptional enhancer factor TEF-4 著者 Sturbaut, M, Allemand, F, Guichou, J.F. 登録日 2019-07-02 公開日 2020-07-22 最終更新日 2022-02-02 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
4UPK	Phosphonate monoester hydrolase SpPMH from Silicibacter pomeroyi 分子名称: PHOSPHONATE MONOESTER HYDROLASE 著者 Valkov, E, van Loo, B, Hollfelder, F, Hyvonen, M. 登録日 2014-06-17 公開日 2015-07-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily. J.Am.Chem.Soc., 141, 2019
6S69	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 分子名称: 3-[3-(3,4-dichlorophenyl)-4-(2-phenylethylcarbamoyl)pyrazol-1-yl]propanoic acid, MYRISTIC ACID, Transcriptional enhancer factor TEF-4 著者 Sturbaut, M, Allemand, F, Guichou, J.F. 登録日 2019-07-02 公開日 2020-07-22 最終更新日 2022-02-02 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
6S60	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 分子名称: 4-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]butanoic acid, MYRISTIC ACID, Transcriptional enhancer factor TEF-4 著者 Sturbaut, M, Allemand, F, Guichou, J.F. 登録日 2019-07-02 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
6S64	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 分子名称: 3-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]propanoic acid, MYRISTIC ACID, PALMITIC ACID, ... 著者 Sturbaut, M, Allemand, F, Guichou, J.F. 登録日 2019-07-02 公開日 2020-07-22 最終更新日 2022-02-02 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
6S6J	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 分子名称: MYRISTIC ACID, Transcriptional enhancer factor TEF-4, ethyl 1-(4-azanylbutyl)-3-(3,4-dichlorophenyl)pyrazole-4-carboxylate 著者 Sturbaut, M, Allemand, F, Guichou, J.F. 登録日 2019-07-03 公開日 2020-07-22 最終更新日 2022-02-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
1ZH2	Crystal Structure Of The Calcium-Bound Receiver Domain Of Kdp Potassium Transport System Response Regulator KdpE 分子名称: CALCIUM ION, KDP operon transcriptional regulatory protein kdpE 著者 Toro-Roman, A, Wu, T, Stock, A.M. 登録日 2005-04-22 公開日 2005-12-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci., 14, 2005
1ZH4	Crystal Structure Of The Mg+2/BeF3-Bound Receiver Domain Of Kdp Potassium Transport System Response Regulator KdpE 分子名称: BERYLLIUM TRIFLUORIDE ION, KDP operon transcriptional regulatory protein kdpE, MAGNESIUM ION 著者 Toro-Roman, A, Wu, T, Stock, A.M. 登録日 2005-04-22 公開日 2005-12-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci., 14, 2005
1ZGZ	Crystal Structure Of The Receiver Domain Of TMAO Respiratory System Response Regulator TorR 分子名称: GLYCEROL, SULFATE ION, TorCAD operon transcriptional regulatory protein torR 著者 Toro-Roman, A, Wu, T, Stock, A.M. 登録日 2005-04-22 公開日 2005-12-13 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A common dimerization interface in bacterial response regulators KdpE and TorR. Protein Sci., 14, 2005
7CMQ	Crystal Structure of Bacillus sp. TB-90 Urate Oxidase Improved by Humidity Control at 88% RH. 分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ... 著者 Hibi, T, Itoh, T, Nishiya, Y. 登録日 2020-07-28 公開日 2020-08-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase To be published
7CMN	Crystal Structure of Bacillus sp. TB-90 Urate Oxidase Improved by Humidity Control at 88% RH. 分子名称: 1,2-ETHANEDIOL, 8-AZAXANTHINE, OXYGEN MOLECULE, ... 著者 Hibi, T, Itoh, T, Nishiya, Y. 登録日 2020-07-28 公開日 2020-08-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Flexibility of a Distal Interface Loop Modulates Water Network in the Active Site of Bacillus sp. TB-90 Urate Oxidase To be published
7UGR	Crystal structure of hyperfolder YFP 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Hyperfolder yellow fluorescent protein, ... 著者 Campbell, B.C, Liu, C.F, Petsko, G.A. 登録日 2022-03-25 公開日 2022-10-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Chemically stable fluorescent proteins for advanced microscopy. Nat.Methods, 19, 2022
7D8T	MITF bHLHLZ complex with M-box DNA 分子名称: DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit 著者 Guo, M, Fang, P, Wang, J. 登録日 2020-10-09 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.201 Å) 主引用文献 A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
7D8R	MITF HLHLZ structure 分子名称: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit 著者 Guo, M, Fang, P, Wang, J. 登録日 2020-10-09 公開日 2021-10-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
7D8S	MITF bHLHLZ apo structure 分子名称: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION 著者 Guo, M, Fang, P, Wang, J. 登録日 2020-10-09 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
7DCK	Crystal structure of phosphodiesterase tw9814 分子名称: Lactamase_B domain-containing protein, MANGANESE (II) ION 著者 Heo, Y, Yun, J.H, Park, J.H, Park, S.B, Cha, S.S, Lee, W. 登録日 2020-10-26 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structural and functional identification of the uncharacterized metallo-beta-lactamase superfamily protein TW9814 as a phosphodiesterase with unique metal coordination. Acta Crystallogr D Struct Biol, 78, 2022
4UPH	Crystal Structure of Phosphonate Monoester Hydrolase of Agrobacterium radiobacter 分子名称: CHLORIDE ION, MAGNESIUM ION, SULFATASE (SULFURIC ESTER HYDROLASE) PROTEIN 著者 Fischer, G, Loo, B.v, Hyvonen, M, Hollfelder, F. 登録日 2014-06-17 公開日 2015-07-01 最終更新日 2019-07-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily. J.Am.Chem.Soc., 141, 2019
6OTD	Globin sensor domain of AfGcHK in monomeric form, with imidazole 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Globin-coupled histidine kinase, IMIDAZOLE, ... 著者 Skalova, T, Dohnalek, J, Kolenko, P, Stranava, M, Lengalova, A, Martinkova, M. 登録日 2019-05-03 公開日 2020-01-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensorAfGcHK abolishes bacterial signal transduction. J.Biol.Chem., 295, 2020
4Z07	Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ... 著者 Kim, J.J, Reger, A.S, Arold, S.T, Kim, C. 登録日 2015-03-25 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure, 24, 2016
6HTF	Crystal structure of human Btk SH2 domain bound to rF10 repebody 分子名称: Tyrosine-protein kinase BTK, rF10 repebody 著者 Duarte, D.P, Pojer, F, Hantschel, O. 登録日 2018-10-04 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11, 2020
8U89	The structure of the PP2A-B56Delta holoenzyme mutant - E197K 分子名称: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Wu, C.G, Xing, Y. 登録日 2023-09-16 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
8U1X	The structure of the PP2A-B56Delta holoenzyme mutant - E197K 分子名称: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Wu, C.G, Xing, Y. 登録日 2023-09-04 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
8BTJ	Murine cytomegalovirus protein M35 分子名称: (R,R)-2,3-BUTANEDIOL, MALONATE ION, Protein M35 著者 Schmelz, S, Van den Heuvel, J, Blankenfeldt, W. 登録日 2022-11-29 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. J.Virol., 97, 2023
7JM4	IRF Transcription Factor 分子名称: Interferon regulatory factor 4, Interferon-Stimulated Response Elements 著者 Sundararaj, S, Williams, S.J, Casarotto, M.G. 登録日 2020-07-31 公開日 2021-03-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural determinants of the IRF4/DNA homodimeric complex. Nucleic Acids Res., 49, 2021
7PLN	Structure of the APCbeta domain of Plasmodium vivax perforin-like protein 1 分子名称: Sporozoite micronemal protein essential for cell traversal, putative 著者 Williams, S.I, Ni, T, Yu, X, Gilbert, R.J.C. 登録日 2021-08-31 公開日 2022-06-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structural, Functional and Computational Studies of Membrane Recognition by Plasmodium Perforin-Like Proteins 1 and 2 J.Mol.Biol., 434, 2022

<75767778798081828384858687888990>