6HK5
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![BU of 6hk5 by Molmil](/molmil-images/mine/6hk5) | X-ray structure of a truncated mutant of the metallochaperone CooJ with a high-affinity nickel-binding site | 分子名称: | 3,3',3''-phosphoryltripropanoic acid, CALCIUM ION, CHLORIDE ION, ... | 著者 | Alfano, M, Perard, J, Basset, C, Carpentier, P, Zambelli, B, Timm, J, Crouzy, S, Ciurli, S, Cavazza, C. | 登録日 | 2018-09-05 | 公開日 | 2019-03-27 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.042 Å) | 主引用文献 | The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site. J.Biol.Chem., 294, 2019
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8R3D
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![BU of 8r3d by Molmil](/molmil-images/mine/8r3d) | |
5KDO
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![BU of 5kdo by Molmil](/molmil-images/mine/5kdo) | Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | 著者 | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | 登録日 | 2016-06-08 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor. J.Biol.Chem., 291, 2016
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5MUH
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![BU of 5muh by Molmil](/molmil-images/mine/5muh) | Crystal structure of an amyloidogenic light chain dimer H7 | 分子名称: | light chain dimer | 著者 | Oberti, L, Rognoni, P, Russo, R, Maritan, M, Bacarizo, J, Bolognesi, M, Ricagno, S. | 登録日 | 2017-01-13 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. Sci Rep, 7, 2017
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7JWY
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![BU of 7jwy by Molmil](/molmil-images/mine/7jwy) | Structure of SARS-CoV-2 spike at pH 4.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Kwong, P.D. | 登録日 | 2020-08-26 | 公開日 | 2020-11-25 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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2KEB
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![BU of 2keb by Molmil](/molmil-images/mine/2keb) | NMR solution structure of the N-terminal domain of the DNA polymerase alpha p68 subunit | 分子名称: | DNA polymerase subunit alpha B | 著者 | Huang, H, Weiner, B.E, Zhang, H, Fuller, B.E, Gao, Y, Wile, B.M, Chazin, W.J, Fanning, E. | 登録日 | 2009-01-28 | 公開日 | 2010-02-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. J.Biol.Chem., 285, 2010
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7K0C
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![BU of 7k0c by Molmil](/molmil-images/mine/7k0c) | Structure of Secretory IgM Core | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, Immunoglobulin heavy constant mu, ... | 著者 | Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L. | 登録日 | 2020-09-04 | 公開日 | 2021-01-20 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human secretory immunoglobulin M core. Structure, 29, 2021
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8BB5
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![BU of 8bb5 by Molmil](/molmil-images/mine/8bb5) | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker | 分子名称: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | 著者 | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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6CAR
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![BU of 6car by Molmil](/molmil-images/mine/6car) | Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin | 分子名称: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, 16S Ribosomal RNA rRNA, 30S ribosomal protein S10, ... | 著者 | DeMirci, H. | 登録日 | 2018-01-31 | 公開日 | 2018-07-25 | 最終更新日 | 2018-10-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature. Nucleic Acids Res., 46, 2018
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8BB4
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![BU of 8bb4 by Molmil](/molmil-images/mine/8bb4) | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker | 分子名称: | Elongin-B, Elongin-C, WD repeat-containing protein 5, ... | 著者 | Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-10-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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6HN2
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![BU of 6hn2 by Molmil](/molmil-images/mine/6hn2) | Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5 | 分子名称: | 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ... | 著者 | Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. | 登録日 | 2018-09-13 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
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6HMS
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![BU of 6hms by Molmil](/molmil-images/mine/6hms) | Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA | 分子名称: | DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ... | 著者 | Raia, P, Carroni, M, Sauguet, L. | 登録日 | 2018-09-12 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | 主引用文献 | Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases. PLoS Biol., 17, 2019
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5MIY
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![BU of 5miy by Molmil](/molmil-images/mine/5miy) | Crystal structure of the E3 ubiquitin ligase RavN from Legionella pneumophila | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin ligase RavN, SODIUM ION, ... | 著者 | Lucas, M, Abascal-Palacios, G, Rojas, A.L, Hierro, A. | 登録日 | 2016-11-29 | 公開日 | 2018-05-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.717 Å) | 主引用文献 | RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases. PLoS Pathog., 14, 2018
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6HNO
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![BU of 6hno by Molmil](/molmil-images/mine/6hno) | 17beta-hydroxysteroid dehydrogenase 14 variant S205 - mutant H93A | 分子名称: | 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Bertoletti, N, Heine, A, Klebe, G, Marchais-Oberwinkler, S. | 登録日 | 2018-09-17 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Mutational and structural studies uncover crucial amino acids determining activity and stability of 17 beta-HSD14. J.Steroid Biochem.Mol.Biol., 189, 2019
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8S06
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![BU of 8s06 by Molmil](/molmil-images/mine/8s06) | A fragment-based inhibitor of SHP2 | 分子名称: | 1H-pyrrolo[3,2-b]pyridin-7-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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5JSI
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![BU of 5jsi by Molmil](/molmil-images/mine/5jsi) | Structure of membrane protein | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Bacteriorhodopsin, EICOSANE, ... | 著者 | Melnikov, I, Polovinkin, V, Kovalev, K, Shevchenko, V, Gushchin, I, Popov, A, Gordeliy, V. | 登録日 | 2016-05-08 | 公開日 | 2017-05-31 | 最終更新日 | 2023-03-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fast iodide-SAD phasing for high-throughput membrane protein structure determination. Sci Adv, 3, 2017
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8S0P
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![BU of 8s0p by Molmil](/molmil-images/mine/8s0p) | A fragment-based inhibitor of SHP2 | 分子名称: | 1-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]-4-methyl-piperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8S04
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![BU of 8s04 by Molmil](/molmil-images/mine/8s04) | A fragment-based inhibitor of SHP2 | 分子名称: | N-(1H-indol-7-yl)methanesulfonamide, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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6TMI
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![BU of 6tmi by Molmil](/molmil-images/mine/6tmi) | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, peripheral stalk model | 分子名称: | ATP synthase subunit alpha, ATPTG12, Oligomycin sensitivity conferring protein (OSCP), ... | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | 登録日 | 2019-12-04 | 公開日 | 2020-12-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nat Commun, 12, 2021
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8S0K
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![BU of 8s0k by Molmil](/molmil-images/mine/8s0k) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-[2,3-bis(chloranyl)phenyl]-5-methyl-6-(piperazin-1-ylmethyl)-1H-pyrrolo[3,2-b]pyridine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8S0S
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![BU of 8s0s by Molmil](/molmil-images/mine/8s0s) | A fragment-based inhibitor of SHP2 | 分子名称: | (1R,5S)-8-[7-(4-chloranyl-2-methyl-indazol-5-yl)-5H-pyrrolo[2,3-b]pyrazin-3-yl]-8-azabicyclo[3.2.1]octan-3-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
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8HE5
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![BU of 8he5 by Molmil](/molmil-images/mine/8he5) | RNA polymerase II elongation complex bound with Rad26 and Elf1, stalled at SHL(-3.5) of the nucleosome | 分子名称: | DNA (198-MER), DNA repair protein, DNA-directed RNA polymerase subunit, ... | 著者 | Osumi, K, Kujirai, T, Ehara, H, Kinoshita, C, Saotome, M, Kagawa, W, Sekine, S, Takizawa, Y, Kurumizaka, H. | 登録日 | 2022-11-07 | 公開日 | 2023-07-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.95 Å) | 主引用文献 | Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome. J.Mol.Biol., 435, 2023
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6TMG
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![BU of 6tmg by Molmil](/molmil-images/mine/6tmg) | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, membrane region model | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATPTG1, ... | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | 登録日 | 2019-12-04 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nat Commun, 12, 2021
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6CBN
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![BU of 6cbn by Molmil](/molmil-images/mine/6cbn) | x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 7.5 | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 1,2-ETHANEDIOL, Neamine transaminase NeoN | 著者 | Thoden, J.B, Dow, G.T, Holden, H.M. | 登録日 | 2018-02-03 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27, 2018
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6HZK
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![BU of 6hzk by Molmil](/molmil-images/mine/6hzk) | Crystal structure of redox-inhibited phosphoribulokinase from Synechococcus sp. (strain PCC 6301) | 分子名称: | Phosphoribulokinase | 著者 | Wilson, R.H, Bracher, A, Hartl, F.U, Hayer-Hartl, M. | 登録日 | 2018-10-23 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of phosphoribulokinase from Synechococcus sp. strain PCC 6301. Acta Crystallogr.,Sect.F, 75, 2019
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