6HNO
17beta-hydroxysteroid dehydrogenase 14 variant S205 - mutant H93A
Summary for 6HNO
| Entry DOI | 10.2210/pdb6hno/pdb |
| Descriptor | 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total) |
| Functional Keywords | 17b-hsd14, mutation, inhibition, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29265.08 |
| Authors | Bertoletti, N.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. (deposition date: 2018-09-17, release date: 2019-07-31, Last modification date: 2024-01-24) |
| Primary citation | Badran, M.J.,Bertoletti, N.,Keils, A.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. Mutational and structural studies uncover crucial amino acids determining activity and stability of 17 beta-HSD14. J.Steroid Biochem.Mol.Biol., 189:135-144, 2019 Cited by PubMed: 30836176DOI: 10.1016/j.jsbmb.2019.02.009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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